ID   HIR1_CAPAN              Reviewed;         285 AA.
AC   Q5GI04;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Hypersensitive-induced reaction 1 protein {ECO:0000303|PubMed:20507517};
DE            Short=CaHIR1 {ECO:0000303|PubMed:20507517};
DE   AltName: Full=LRR1-interacting protein 3 {ECO:0000303|PubMed:20507517};
DE            Short=CaLRRIP3 {ECO:0000303|PubMed:20507517};
GN   Name=HIR1 {ECO:0000303|PubMed:20507517};
GN   Synonyms=LRRIP3 {ECO:0000303|PubMed:20507517};
OS   Capsicum annuum (Capsicum pepper).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX   NCBI_TaxID=4072 {ECO:0000312|EMBL:AAS98165.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH LRR1,
RP   TISSUE SPECIFICITY, INDUCTION BY PATHOGEN AND HORMONES, AND MUTAGENESIS OF
RP   GLY-2.
RX   PubMed=20507517; DOI=10.1111/j.1364-3703.2007.00410.x;
RA   Jung H.W., Hwang B.K.;
RT   "The leucine-rich repeat (LRR) protein, CaLRR1, interacts with the
RT   hypersensitive induced reaction (HIR) protein, CaHIR1, and suppresses cell
RT   death induced by the CaHIR1 protein.";
RL   Mol. Plant Pathol. 8:503-514(2007).
CC   -!- FUNCTION: Positive regulator of hypersensitive response (HR)-like cell
CC       death. May be involved in potassium ion channel regulation.
CC       {ECO:0000269|PubMed:20507517}.
CC   -!- SUBUNIT: Homo- and heterodimer. Interacts with LRR1 (via LRR domain).
CC       {ECO:0000269|PubMed:20507517}.
CC   -!- TISSUE SPECIFICITY: Constitutively expressed in stems, roots and
CC       flowers, but not in leaves and fruits. {ECO:0000269|PubMed:20507517}.
CC   -!- INDUCTION: Up-regulated by pathogens during an incompatible
CC       interaction, but not upon infection by a virulent pathogen. Up-
CC       regulated by salicylic acid, abscisic acid, ethylene and methyl
CC       jasmonate. {ECO:0000269|PubMed:20507517}.
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DR   EMBL; AY529867; AAS98165.1; -; mRNA.
DR   RefSeq; NP_001311766.1; NM_001324837.1.
DR   AlphaFoldDB; Q5GI04; -.
DR   SMR; Q5GI04; -.
DR   GeneID; 107862499; -.
DR   KEGG; cann:107862499; -.
DR   Proteomes; UP000189700; Genome assembly.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Lipoprotein; Myristate.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..285
FT                   /note="Hypersensitive-induced reaction 1 protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000439389"
FT   COILED          118..190
FT                   /evidence="ECO:0000255"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         2
FT                   /note="G->A: Loss of hypersensitive cell death induction."
FT                   /evidence="ECO:0000269|PubMed:20507517"
SQ   SEQUENCE   285 AA;  31349 MW;  735E9D6772E90611 CRC64;
     MGNLFCCVQV DQSTVAIKEQ FGKYRDVLEP GCHCVPWFLG SQLAGHLSLR VQQLDVRCET
     KTKDNVFVNV VASIQYRALA DKANEAFYKL SNTKGQIQAY VFDVIRASVP KLNLDDVFEQ
     KNEIAKSVEE ELEKAMSAYG YEIVQTLIVD IVPDEHVKRA MNEINAAARL RVAANEKAEA
     EKILQIKRAE GEAESKYLSG LGIARQRQAI VDGLRDSVLG FSVNVPGTTA KDVMDMVLVT
     QYFDTMKEIG AASKSSAVFI PHGPGAVKNV AQQIRDGLLQ ASVGH