ID   HIR1_CHAGB              Reviewed;        1080 AA.
AC   Q2GSJ9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; ORFNames=CHGG_09055;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CH408034; EAQ85041.1; -; Genomic_DNA.
DR   RefSeq; XP_001226982.1; XM_001226981.1.
DR   AlphaFoldDB; Q2GSJ9; -.
DR   SMR; Q2GSJ9; -.
DR   STRING; 38033.XP_001226982.1; -.
DR   PRIDE; Q2GSJ9; -.
DR   EnsemblFungi; EAQ85041; EAQ85041; CHGG_09055.
DR   GeneID; 4395314; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_3_1_1; -.
DR   InParanoid; Q2GSJ9; -.
DR   OMA; RGSWDGD; -.
DR   OrthoDB; 685536at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1080
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286407"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          68..107
FT                   /note="WD 2"
FT   REPEAT          129..168
FT                   /note="WD 3"
FT   REPEAT          171..210
FT                   /note="WD 4"
FT   REPEAT          232..275
FT                   /note="WD 5"
FT   REPEAT          278..336
FT                   /note="WD 6"
FT   REPEAT          340..381
FT                   /note="WD 7"
FT   REGION          430..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1051..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          469..496
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        440..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        458..479
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..541
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1080 AA;  116351 MW;  4FBB2FEE18C1C18D CRC64;
     MHIIKPSWLR HSGEQKDFEV YSCHISPDGS RLATAGGDGH VRVWSTKAIF NADHPDHGKP
     RQLCHMSHHL GTIHSVRFSP NGRYLASGAD DRVICIYQLD SNPPSHTATF GTNEPPPVEN
     WKTHKRLVGH DSDVQDLAWS YDNSILVSVG LDSKVVVWSG HTFEKLKTIA VHQSHVKGIT
     FDPANKFFAT AGDDRHIKIF RFTPPPPNAT QHDMVNNFVL ETTISAPFKS SPLTTYFRRC
     SWSPDGNHIA AANAVNGPVS SVAIIERSRW DSEINLIGHE GPTEVCMFSP RLFHTQKPSD
     NATDKGSPGL VTVIASAGQD KTLSIWNTNT SRPVVILQDV ASKSMSDLAW TPDGQTLFAS
     SLDGTILAVK FEMGELGWVA TAEENDKALQ KYGGSRKGMG TAEDVDGLHL ENHSKEGELR
     GAESRMGALM GDFQPEDKGK PVTTNGSRPT AKNGEANGTT EPKEKEAPKA APAEENVEKT
     AERIAELKSR VQVTKDGKKR VAPLLVSSSA TGLLSLPQSQ LVGAKSTKTT QSDTPQTILD
     LSKPSHGLPR GGIAAMLLGN KRKAAAMEGE EEDELAGRRP SAGPVPILID TPEGLEPAPL
     SAPAQGVVPT PEYLRPAVIS PAISFSQTRL AVPKVRSHIV RPLEKGVLQG ESTLDEASKV
     PENIVLEAKN PIRLREPAHI SASKRGARLW QDYLPRAIIL VTGNKHFWAA ACEDGSVHTW
     TPAGRRLLNG IILESQPVIL ESREHWLLCI TSVGLCHVFN IKTMSAAHPP VSLAPILDIA
     ITSLSLEGPT PAPGVTSAHL NSVGAVVVTL SNGDGFYYSS TMYAWQRLSE SWWALGSQYW
     NSNDSSISAL STTAVGPVTA KNINGTASST TTTTTPDKPD TAATAEVGVS AGIIPHLERH
     TTSEFLLKGR AFTLQRLIKT LLSKDGFEGF ESTVSVAHLE NRIAGALALG AREEFRLYLF
     MYAKRIGAEG LRGKVEELLN CLVGGLLQQK GAPTNGGGGS GEAKGWFGKG EMLGGWERRE
     LLKGVVLILG KFRDLQRLTV QYARILGLTA DGEDEENDDN NGGGGGENGA VAEEMELEEQ