ID   HIR1_COCIM              Reviewed;        1061 AA.
AC   Q1DHE1; I9XM51;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; ORFNames=CIMG_10272;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS27667.3; -; Genomic_DNA.
DR   RefSeq; XP_001239250.1; XM_001239249.2.
DR   AlphaFoldDB; Q1DHE1; -.
DR   SMR; Q1DHE1; -.
DR   STRING; 246410.Q1DHE1; -.
DR   PRIDE; Q1DHE1; -.
DR   EnsemblFungi; EAS27667; EAS27667; CIMG_10272.
DR   GeneID; 4557941; -.
DR   KEGG; cim:CIMG_10272; -.
DR   VEuPathDB; FungiDB:CIMG_10272; -.
DR   InParanoid; Q1DHE1; -.
DR   OMA; RGSWDGD; -.
DR   OrthoDB; 685536at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50974; SSF50974; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1061
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286408"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          69..108
FT                   /note="WD 2"
FT   REPEAT          130..169
FT                   /note="WD 3"
FT   REPEAT          172..211
FT                   /note="WD 4"
FT   REPEAT          233..276
FT                   /note="WD 5"
FT   REPEAT          279..340
FT                   /note="WD 6"
FT   REPEAT          344..385
FT                   /note="WD 7"
FT   REGION          430..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1061 AA;  114509 MW;  754CEB0D8AC0E353 CRC64;
     MHIIKPVWLT HGGDRKDYEV YSCDVSPDGK RLVTAAGDGY VRIWSTDAIY NAADPEYADK
     PKQLASLSNH SGTIHAVRFS HNGKYLASGA DDKIVCVYVH EPNPPSHTST FGTNEPPPVE
     NWRTIRRLIG HDNDVQDLGW SWDSSILVSV GLDSKVVVWS GHTFEKLKTI PSHQSHVKGI
     TFDPANKYFA TASDDRTIRI FRFTSPTPNS TAHDQIQNFV LEHTVKAPFV NSPLTTYFRR
     CSWSPDGTHI AAANAVNGPV SAAAIINRGS WDSDINLIGH EAPVEVCAFS PRLYSFSPPG
     KNATDNQGNA GPTLVTVIAC AGGDKSLSVW ITINPRPIVI TQDLSAKAIS DLAWSPDGKN
     LFATALDGTI LVVRFEDQEL GYPMPMEENE KSLTKFGTSR RGAGIVESAN GLLLEEMSKA
     GEIKGVEGRM GALMGDGHPS TDQGVNGTPG DLSRSGAATA GTATPTGTQK PQQNGTPNGT
     PGDQEKPDPY AAKLERLKQR PTYTKDGKKR IAPLLVSGAG GTQSSLPQSR LVASSASGLA
     GRSEGPETVL DLSKPFDGLP KGGIAAILFG NKRKFAQMED GEDNSVEKRV AAASQHGANP
     VLINEPDGLV PAAQTARELQ ETPEFIRPAV VNPVMAVSQI RLAVPKVRVH IVQGIDTFGN
     PTSVSSGLAS SSQSKADLTL EARNHSGPSL TGRVTDREPS RVSLTRGDQP LWQDFLPKAV
     LLVTGNKKFW AAATEDGSVY IWTPAGRRLV SALVLEAQPV LLECRESWLL CITAVGMCYV
     WNVTTLTSPH PPISLAPVLD AAVHTMTQTP TTVPSIIAAR ISSQGRIILA VSNGDGYSYN
     PSLYTWQRLS EPWFAVASQY WNTTDSSVGD LQLARNQTGP DAAISAGIIP FLERNTTDEI
     VVRGRAYFLQ RLIKVLLSKE GFESFEAGAS IAHLENRVAA ALSLGAKEEF RLYLLMYAKR
     LGAEGLKMKT EELLEGLIGG IFSEGEEKEN SVTGDKGKNS EEGLWECESD TICGWPRRDL
     LKEVVLALGK HRDLQRITVP YAHLLGILDE DKNEADAMVI T