ID   HIR1_CRYNB              Reviewed;         881 AA.
AC   P0CS39; Q55N02; Q5KBD1; Q5KBD2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; OrderedLocusNames=CNBH2820;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P0CS39-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0CS39-2; Sequence=VSP_041431, VSP_041432;
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; AAEY01000042; EAL19183.1; -; Genomic_DNA.
DR   RefSeq; XP_773830.1; XM_768737.1. [P0CS39-1]
DR   AlphaFoldDB; P0CS39; -.
DR   SMR; P0CS39; -.
DR   EnsemblFungi; AAW45343; AAW45343; CNI02950.
DR   EnsemblFungi; EAL19183; EAL19183; CNBH2820. [P0CS39-1]
DR   GeneID; 4937805; -.
DR   KEGG; cnb:CNBH2820; -.
DR   VEuPathDB; FungiDB:CNBH2820; -.
DR   HOGENOM; CLU_004372_3_0_1; -.
DR   Proteomes; UP000001435; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Chromatin regulator; Nucleus; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..881
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000410332"
FT   REPEAT          17..56
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          129..168
FT                   /note="WD 3"
FT   REPEAT          171..210
FT                   /note="WD 4"
FT   REPEAT          219..262
FT                   /note="WD 5"
FT   REPEAT          265..318
FT                   /note="WD 6"
FT   REPEAT          322..363
FT                   /note="WD 7"
FT   REPEAT          588..635
FT                   /note="WD 8"
FT   REPEAT          688..733
FT                   /note="WD 9"
FT   REGION          398..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         827
FT                   /note="H -> Q (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041431"
FT   VAR_SEQ         828..881
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041432"
SQ   SEQUENCE   881 AA;  96315 MW;  E2B492A2185A1ECA CRC64;
     MKVTKPNWVE HTVGEKKAKT AIYSISVHPD GTRLATGGLD HKVKIWSTLP ILDVEAEKEE
     ENPKLLCTMS SHTGSVLSVR WAHHGRFLAT GSDDQVIMIW GLDPDGGGRL WGSDEINVEN
     WKALTRLVGH VADVVDLAWS RDDTMLASVG LDSTVWIWDG LTFERLRKLD LHQGFVKGVC
     WDPVGNYLAT QSDDKTVKIW NTEDWSLAET ISKPFETSPQ STFFRRLSWS PDGAFIAASN
     AMNGPVFVAA VIDREGWASD ISFVGHENTI QVAAFNPRLF FPEGEPKGRA TASSMLALGA
     NDFSISIWRN TLYKPLVVLK DIFGADLMDL CWSNDGYVLY GSSVDGSVCA IQFEPSEFTD
     LADFSATELV LREYDYKPKR AHQPLAVHSS AASITNGFGP STTTSTHVNV LQPKKGKAKR
     RVDLSNGNIN AGPSAGPSRQ ALRPPPPVDP FSGPIQGFAS PSTAQASTAR MFEDAHRAFG
     PGSGSISGTS PRAGDKRKAS GSYEDPTRGV RGRGMPVQQP IQQFEVQIIR APMVAPSPSD
     AGPSKAYLPY PQVQSILRAQ AIGNESRSIY LEARNTSDPK GENVLCYFAD GEQRWMDYLP
     KAALAVTVTK NFCAAACEDG SLRVYSPAGR LILNMKLSGL VYDLQGEDKM LLIITMDCQV
     RVINVRNGKA FSPPSSIHHL LFPGSSSFHS FDIISCTVRP NGVPVIITSE PQAFAYDASL
     HEWSTIASPP IAGIQPLPSG PSGPLSVVDQ IVAKSAPVTT TEKSNAPWIE ESYVMSQFEM
     KLRGTVLLDS KEEHKHWLLG YMKYLGDENF AERAGEVMKD LIGPVYHQSK PTGWEPKLLG
     VDKREIAAEV LDVLSKTLQG KNVASVWYDV LDKMKADEGS W