HIR1_CRYNJ
ID HIR1_CRYNJ Reviewed; 881 AA.
AC P0CS38; Q55N02; Q5KBD1; Q5KBD2;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=CNI02950;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0CS38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0CS38-2; Sequence=VSP_025047, VSP_025048;
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017349; AAW45342.1; -; Genomic_DNA.
DR EMBL; AE017349; AAW45343.1; -; Genomic_DNA.
DR RefSeq; XP_572649.1; XM_572649.1. [P0CS38-2]
DR RefSeq; XP_572650.1; XM_572650.1. [P0CS38-1]
DR AlphaFoldDB; P0CS38; -.
DR SMR; P0CS38; -.
DR STRING; 5207.AAW45343; -.
DR PaxDb; P0CS38; -.
DR EnsemblFungi; AAW45342; AAW45342; CNI02950. [P0CS38-2]
DR EnsemblFungi; AAW45343; AAW45343; CNI02950. [P0CS38-1]
DR GeneID; 3259556; -.
DR KEGG; cne:CNI02950; -.
DR VEuPathDB; FungiDB:CNI02950; -.
DR eggNOG; KOG0973; Eukaryota.
DR InParanoid; P0CS38; -.
DR OMA; NWVTHDG; -.
DR OrthoDB; 685536at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Chromatin regulator; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..881
FT /note="Protein HIR1"
FT /id="PRO_0000286409"
FT REPEAT 17..56
FT /note="WD 1"
FT REPEAT 71..110
FT /note="WD 2"
FT REPEAT 129..168
FT /note="WD 3"
FT REPEAT 171..210
FT /note="WD 4"
FT REPEAT 219..262
FT /note="WD 5"
FT REPEAT 265..318
FT /note="WD 6"
FT REPEAT 322..363
FT /note="WD 7"
FT REPEAT 588..635
FT /note="WD 8"
FT REPEAT 688..733
FT /note="WD 9"
FT REGION 398..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 827
FT /note="H -> Q (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_025047"
FT VAR_SEQ 828..881
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_025048"
SQ SEQUENCE 881 AA; 96315 MW; E2B492A2185A1ECA CRC64;
MKVTKPNWVE HTVGEKKAKT AIYSISVHPD GTRLATGGLD HKVKIWSTLP ILDVEAEKEE
ENPKLLCTMS SHTGSVLSVR WAHHGRFLAT GSDDQVIMIW GLDPDGGGRL WGSDEINVEN
WKALTRLVGH VADVVDLAWS RDDTMLASVG LDSTVWIWDG LTFERLRKLD LHQGFVKGVC
WDPVGNYLAT QSDDKTVKIW NTEDWSLAET ISKPFETSPQ STFFRRLSWS PDGAFIAASN
AMNGPVFVAA VIDREGWASD ISFVGHENTI QVAAFNPRLF FPEGEPKGRA TASSMLALGA
NDFSISIWRN TLYKPLVVLK DIFGADLMDL CWSNDGYVLY GSSVDGSVCA IQFEPSEFTD
LADFSATELV LREYDYKPKR AHQPLAVHSS AASITNGFGP STTTSTHVNV LQPKKGKAKR
RVDLSNGNIN AGPSAGPSRQ ALRPPPPVDP FSGPIQGFAS PSTAQASTAR MFEDAHRAFG
PGSGSISGTS PRAGDKRKAS GSYEDPTRGV RGRGMPVQQP IQQFEVQIIR APMVAPSPSD
AGPSKAYLPY PQVQSILRAQ AIGNESRSIY LEARNTSDPK GENVLCYFAD GEQRWMDYLP
KAALAVTVTK NFCAAACEDG SLRVYSPAGR LILNMKLSGL VYDLQGEDKM LLIITMDCQV
RVINVRNGKA FSPPSSIHHL LFPGSSSFHS FDIISCTVRP NGVPVIITSE PQAFAYDASL
HEWSTIASPP IAGIQPLPSG PSGPLSVVDQ IVAKSAPVTT TEKSNAPWIE ESYVMSQFEM
KLRGTVLLDS KEEHKHWLLG YMKYLGDENF AERAGEVMKD LIGPVYHQSK PTGWEPKLLG
VDKREIAAEV LDVLSKTLQG KNVASVWYDV LDKMKADEGS W
