ID   HIR1_DEBHA              Reviewed;         985 AA.
AC   Q6BYU4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; OrderedLocusNames=DEHA2A06908g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84581.2; -; Genomic_DNA.
DR   RefSeq; XP_456625.2; XM_456625.2.
DR   AlphaFoldDB; Q6BYU4; -.
DR   SMR; Q6BYU4; -.
DR   STRING; 4959.XP_456625.2; -.
DR   EnsemblFungi; CAG84581; CAG84581; DEHA2A06908g.
DR   GeneID; 2899820; -.
DR   KEGG; dha:DEHA2A06908g; -.
DR   VEuPathDB; FungiDB:DEHA2A06908g; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_3_0_1; -.
DR   InParanoid; Q6BYU4; -.
DR   OMA; YEFQMEH; -.
DR   OrthoDB; 685536at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..985
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286410"
FT   REPEAT          13..54
FT                   /note="WD 1"
FT   REPEAT          87..126
FT                   /note="WD 2"
FT   REPEAT          147..186
FT                   /note="WD 3"
FT   REPEAT          189..228
FT                   /note="WD 4"
FT   REPEAT          248..291
FT                   /note="WD 5"
FT   REPEAT          314..353
FT                   /note="WD 6"
FT   REPEAT          357..398
FT                   /note="WD 7"
FT   REGION          556..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   985 AA;  111043 MW;  CED1625F417BD0FC CRC64;
     MHILKLPWFG HKAENKQIEC YSVSINSDGS RLASGGLDGN VKIWDTKSIL HFKNYEAEPA
     TLNNKNGINL DTLNSDIIRR PLCSMSRHNG VVTSVKFSPD GRFLASGSDD KIVLIWEKDE
     EQANRPKQFG EAEADLEHWT VRKRLVAHDN DIQDICWSPD GSLLVTVGLD RSIIIWNGLT
     FERIKRYDIH QSMVKGIVFD PANKFFATAS DDRSVRIFRY YRKLSESSIN NYEFQMEHIV
     IDPFKKSPLT SYFRRMSWSP DGQHIAVPNA TNGPVTSVAI INRTNWGTDI SLIGHEAPCE
     VCCFSPRLFE YDDSNDSQKN KNGMGNFTTI LATAGQDQNL VVWTTRQSKP LVVAHDIVSG
     SITDMCWAPD GQTLYFSCLD GSITCVSFED NELGKVVSEN MNDLQLHRYG ADRESATFPE
     SVEQLLLEEK SEVTEHKENK KLAITKPPTT ILKSRPEEVR PKEVSPKINN LTPKQVNKLT
     QSITITKNGK KRVAPLLVSS SSKISVPVLG TSGKVTKKFQ IGSKLSQTSY FLPRLGVSTS
     VQGLKSKNLV HEFNQTNEAN NDDQDNDNED MGIDSAKVND NPKDALNQSV SDATLRRQRN
     KIKRAILETR YPSCFQLIST LPDNLFNNQA ILNSKVNQIL NNNFNSKREN NNEIISGSSI
     DAIDEDLIFS VIVTGIQSIE DRSSIIINDA YDANTSITSI VEVRNGPSWK VNEDDITDFE
     YGDRIDFQDP TRVIVSNDQN HTKRSYTVFF PYKVQHVLPI IKNRILTFYV LASFNGTIQI
     ISAKSGKYVT ASMEVGNNVI LLKQEGDYLM CVTNQGLIFV WKLPNLPVER FLTGVVRGIS
     LAPILNNMVE VPSIEKKNLN KRHANIPQLM MPNVRKLDVD TRNGSPLAIL EDNNEVYKFS
     LDLMVWIKVV DPWYFLALTD SPVDSFKTGN CIDSLLHKSY KSFEEDVKRS KIGLYIYNNS
     EETNELQKVM EARFKQSIEL AGQIA