HIR1_EMENI
ID HIR1_EMENI Reviewed; 1031 AA.
AC Q5BDU4; C8VSF2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein hir1;
GN Name=hir1; ORFNames=AN1286;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF87791.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA65879.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000017; EAA65879.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001308; CBF87791.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_658890.1; XM_653798.1.
DR AlphaFoldDB; Q5BDU4; -.
DR SMR; Q5BDU4; -.
DR STRING; 162425.CADANIAP00001334; -.
DR EnsemblFungi; EAA65879; EAA65879; AN1286.2.
DR GeneID; 2877067; -.
DR KEGG; ani:AN1286.2; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_1_1; -.
DR InParanoid; Q5BDU4; -.
DR OrthoDB; 685536at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1031
FT /note="Protein hir1"
FT /id="PRO_0000286411"
FT REPEAT 36..75
FT /note="WD 1"
FT REPEAT 87..126
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 190..229
FT /note="WD 4"
FT REPEAT 251..294
FT /note="WD 5"
FT REPEAT 297..358
FT /note="WD 6"
FT REPEAT 362..403
FT /note="WD 7"
FT REGION 449..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 110967 MW; 492F42044DEF7D39 CRC64;
MDILYRPMLL SIYVCRASRT VLANIFVSFS GFLGERKAFE VYSCDVSPDG SRLVTAAGDG
YVRIWSTEAI CGAEDANKPK QLASMSNHSG TIHTVRFSPN GKYLASGADD KIVCIYTLDA
NPPSHAASFG SNEAPPVENW RTIRRLIGHD NDVQDLGWSC DSSILVSVGL DSKVVVWSGH
TFEKLKTLSV HQSHVKGITF DPANKYFATA SDDRTVRIFR FTSPAPNSTA HDQMNNFVLE
QTITAPFQNS PLTAYFRRCS WSPDGLHIAA ANAVNGPVSS VAIINRGGWD GDINLIGHEA
PVEVCAFSPR LYSPQPIKKN QQDSHDHVAQ APVTVIACAG GDKSLSVWIT SNPRPIVVAQ
ELAAKSISDL AWSPDGSCLY ATALDGTILA VRFEDGDLGY AMELEENEKS LTKFGTNRKG
AGIAETTDGL LLEEKSKAGE LKGVEGRMGA LMGDGHATGD AVANGKPTPL PSTSNGVTPA
APSPSTDAQK SQPNGTAAPS ASETEKPDPY QAKLERLKQR PTYTKDGKKR IAPLLVSGAG
GAESSLPQAR LMASVSSQVK ADTPQSIVDL SKPFDGLPKG GLATLLFGNK RKLAQLEDEE
DGHTEKRVAL ASQNGATPIL TSAPEGLLPA QPQDPPTGQQ PTPEFIRPAV VNPCMSVSQL
RLAVPKVRTH IVRAIDSAGK PTEPPSTSGE SNKSRVDVVF EARNPSGASL TGRAADREPV
RLTLFRGEQP LWQDFLPRTV LLVTGNQNMW SAACEDGSVY IWTPAGRRLV SALVLEAQPV
ILECNGPWIL SISAVGMCYV WNVEHLSSPH PPVSLQPVLD AAIHTLGAHP SAAPSITNAR
INSEGRIIIA LSNGEGYAYS PSLYTWQRLS EAWWAVGSQY WNSTEAPVGN LQSASNTQQK
DKDARAAVSA GIIPFLERNT TNETLLRGRA YFLQRLIKTL LSREGYESFE SSVSIAHLEN
RLAGALSLGA KEEFRLYLSM YAKRIGAEGL RGKVEELLKG KHRDLQRVTV PYAKLLGVVD
NESDANDAME L
