HIR1_GIBZE
ID HIR1_GIBZE Reviewed; 1046 AA.
AC Q4IBR4; A0A0E0SP11; V6R9I7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; ORFNames=FGRRES_05344, FGSG_05344;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231665; ESU11288.1; -; Genomic_DNA.
DR EMBL; HG970334; CEF88174.1; -; Genomic_DNA.
DR RefSeq; XP_011323864.1; XM_011325562.1.
DR AlphaFoldDB; Q4IBR4; -.
DR SMR; Q4IBR4; -.
DR STRING; 5518.FGSG_05344P0; -.
DR EnsemblFungi; ESU11288; ESU11288; FGSG_05344.
DR GeneID; 23552530; -.
DR KEGG; fgr:FGSG_05344; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G17681; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_1_1; -.
DR InParanoid; Q4IBR4; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1046
FT /note="Protein HIR1"
FT /id="PRO_0000286412"
FT REPEAT 15..54
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 127..166
FT /note="WD 3"
FT REPEAT 169..208
FT /note="WD 4"
FT REPEAT 230..273
FT /note="WD 5"
FT REPEAT 292..333
FT /note="WD 6"
FT REPEAT 337..378
FT /note="WD 7"
FT REGION 426..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 114268 MW; 57AE4E0A3FF52DD5 CRC64;
MHIIKPSWLS HCGEQKDFEV YSCHVSPDGK RLATAGGDGH VRVWSTESIY NANTPDYNKP
RQLCHMSHHL GTIHSVRFSP NGRYLASGAD DKIICVYHLD KNPPAATFGT NEPPPIENWK
TYKRLIGHDN DVQDLAWSYD SSILVSVGLD SKVVVWSGHT FEKLKTLPAH QSHVKGITFD
PANKFFATAS DDRTIKIFRF TSPAPNATQH DMVNNFVLET TISSPFKSSP LTTYFRRCSW
SPDGNHIAAA NAVNGPVSSV AIIERTRWDS EINLIGHEAP TEVCMFSPRL FHTSKPDPSV
DDKSPSLVTV IASAGQDKTL SIWNTNTSRP VVILQDLAGK SVSDLAWTPD GQTLFASSLD
GSIVVAKFSE GELGWVAQPE ENDKALQKYG ASRKGMGIAE DVDGLMLENQ SKAGESRAVE
SRMGALMGDL PDSTKESTPV TNGTKTTAPT SKPATNGQSE AEKDKEPEKE QEKEPEEAAD
KTAQRVKELK SRVTVGKDGK KRVAPLLVSS SGTGTSSLPQ TQLVGTTSNN KAAQNDAPQT
TLDLAKPFDG LPKGGIAAML LGNKRRLNLG EAEEEEEPVS KRAATGPTTI VTNGHDSVEP
AALVPVQHGV VPTPEFLRPA VMNPSIAFAQ VRLAVPKIRS HVLRPLDRGI LQGESSLEDA
SKTPENIILE AKNDPNPRDP SHVLVSKRGA LIWEEWLPRA IILVTATKQF WAVACEDGSI
HTWTPAGRRL LAPIILESQP VILEARGHWL LCITAVGLAH VWDLKTQSSP SPPVSLGPIL
DIATTSLNQH SATPGPGVTS AHLNSTGHII VTLTNGDGYY YAREMFTWQR LSEAWWAVGS
QYWNSNDSSI SALQSTAVGP ASKEGKDKES TKATVSSGII PFLERHTTNE FLLKGRAYGL
QRIIKMVVQR KEAENLESSV SIAHLETRIA GALQLGAREE FRLYLFTYAK RLGAEGARVK
VEELLNSLLG GILEENEEEE DEDDGHGWFS KEGDLCGWDR KELLKDVVMI LGKYRELQRL
TLQYAKVLDI SLEDGPVDVE QMDVEA
