HIR1_KLULA
ID HIR1_KLULA Reviewed; 861 AA.
AC Q6CXX3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=KLLA0A04928g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CR382121; CAH02804.1; -; Genomic_DNA.
DR RefSeq; XP_451216.1; XM_451216.1.
DR AlphaFoldDB; Q6CXX3; -.
DR SMR; Q6CXX3; -.
DR STRING; 28985.XP_451216.1; -.
DR EnsemblFungi; CAH02804; CAH02804; KLLA0_A04928g.
DR GeneID; 2896848; -.
DR KEGG; kla:KLLA0_A04928g; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q6CXX3; -.
DR OMA; KRFDVHQ; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..861
FT /note="Protein HIR1"
FT /id="PRO_0000286413"
FT REPEAT 14..54
FT /note="WD 1"
FT REPEAT 74..113
FT /note="WD 2"
FT REPEAT 132..171
FT /note="WD 3"
FT REPEAT 174..213
FT /note="WD 4"
FT REPEAT 227..270
FT /note="WD 5"
FT REPEAT 295..337
FT /note="WD 6"
FT REPEAT 341..382
FT /note="WD 7"
FT REGION 450..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 96002 MW; 60F5284E1580D1F9 CRC64;
MKLLKLPWLQ HREEHKSYEV YTCDVSPDSQ RLATGGLDGK IRIWSIPDIL KFASNPNAST
DKDILMKPLS TMSRHAGSVT TVKFSPDGKY LASGSDDRIL LIWELEGGTT QPMFGAESTD
IEHWNVRRRL VAHDNDIQDI CWAPDSSIMV SVGLDRAIII WNGSTFEKVK RFDVHQSHVK
GVVFDPANKY FATASDDRTI KMFRYHKTGE TSFSVEHVIT EPFKGSPLTT YFRRLSWSPD
GQHIAAPNAM NGPVSTVAII ERGTWESPVS LVGHDQPTEV ASFNPRIFKR QKDDSTTDTI
DGKKTGISDE VDCIVASSGQ DKTLAVWSTS KARPLIVAQD ICGKSITDMS WTPDGKILFI
TSLDSSIVVL TFEDNEFGEA IPLEQNIEYL HRYGVDKDSL VFPETVEQLI LEDQAKNLKK
SNVDMNLLEN RLGKPGTIAE PNILQVRSKK RAQLTGTGNH TDNNTTSKAE PPHVNILQVK
RKNKVTGVTE VLHDTVVKNG KKRVAPTLIT MGHSPDKSRK RVILSTAQSL NNTVQPTTKP
APEEKSTLAK LQSTKLSKPS FSIPRLGIHT LIMGFKERTR ENFINQGSTD STVDESNVNI
DEGPQQLEQN SAEEHLLTLN SKTTLEKIWR DEPNTRYLEF NSILPDADAV LREMGTIDDL
YVLEVRNGVE RSIQFDTEAL YDNSTRVLGY HAGQRSFELF FPDVVLTCVG CMETKTWILA
TTTGQLFFID TLGQARCPRI SIGHKIIKLC TSQSHVIAIT ETALIYVWDL VSMSLTLKNI
PLLPLLARDP ITGNRARFTS KIKSAKMTEN KDLQLVMTDI APDSDSNPST LHFLYSSSLS
CWCSPKEALL VDASVEQVIT S
