HIR1_NEUCR
ID HIR1_NEUCR Reviewed; 1035 AA.
AC Q7RZI0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Protein hir-1;
GN Name=hir-1; ORFNames=B10H18.120, NCU04035;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE85596.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX897678; CAE85596.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM002241; EAA28414.2; -; Genomic_DNA.
DR RefSeq; XP_957650.2; XM_952557.3.
DR AlphaFoldDB; Q7RZI0; -.
DR SMR; Q7RZI0; -.
DR STRING; 5141.EFNCRP00000003682; -.
DR EnsemblFungi; EAA28414; EAA28414; NCU04035.
DR GeneID; 3873772; -.
DR KEGG; ncr:NCU04035; -.
DR VEuPathDB; FungiDB:NCU04035; -.
DR HOGENOM; CLU_004372_3_1_1; -.
DR InParanoid; Q7RZI0; -.
DR OMA; RGSWDGD; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1035
FT /note="Protein hir-1"
FT /id="PRO_0000286414"
FT REPEAT 15..54
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 129..168
FT /note="WD 3"
FT REPEAT 171..210
FT /note="WD 4"
FT REPEAT 232..275
FT /note="WD 5"
FT REPEAT 299..338
FT /note="WD 6"
FT REPEAT 342..383
FT /note="WD 7"
FT REGION 393..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 112439 MW; 7C6BC5BED3E50B93 CRC64;
MHLIKPSWLS HSGEQKDFEV YSCHVSPDGK RLATAGGDGH VRVWSVEAIF NSHDRNYTKP
RQLCHMSHHL GTIHSVRFSP NGRYLASGAD DKIICIYHLD SNPPSHTSTF GTNEPPPVEN
WKTYKRLVGH DNDVQDLAWS PDNSLLVSVG LDSKIVVWSG HTFEKLKTLA VHQSHVKGIT
FDPANKFFAT ASDDRTIKIF RYTAPAPNAT QHDMVNNFIL ETSISVPFKH SPLTTYFRRC
SWSPDGNHIA AANAVNGPVS SIAIIERTGW DSEINLIGHE APTEVCMFSP RLFYTQKPDE
NSNANGAASP GLVTVIASAG QDKTLTIWNT NTSRPVLIVQ DIASKSVSDL AWTPDGQTVF
AASLDGGVIA AQFETGELGW VAKSEENDKA LQKYGGSRKG MGTAEDVDGL HLENHSKEKE
LRGAESRMGA LMGDPGPAQK ETATTTNGVK PAGKAADTNG TTTPAPPEKP EEESADKTAE
RIAELKSRVT ITKDGKKRVA PLLVSSSGTG LSSLPQAQLV GASSTKPVQN DNPQTILDLS
KPYDGLPRGG IAAMLLGNKR KAVIVEDEEE EEPSAKRSAT GPVPIVVNGV EGLEPAPLSA
PAHGLVPTPE FLRPAVISPN IAYSQVRLAV PKIRSHILRP LERGVLQEET SLEDATKVPE
NIVLEAKNPA HIREPARITA TKRGALLWQD FLPRAIILVA GSKHFWAAAC EDGTLHTWSP
AGRRLMNAIM LESQPVILEA RDSWLLCVTA VGLCHVYNIK TMSSPHPPVS LAPILDVAMT
SLSPHGATPA PGVTSAHLNS SGVIVVTLSN GDGFYYSTSL YAWQRLSESW WAVGSQYWNS
NDSSVSALQT TAVGPVSGAK NGEGETNVSA GIIPYLERHT TTEFLLKGRA YTLQRLVKAL
LARDGFENFE SSVSIAHLEN RIAGAFALGA REEFRLYLFM YAKRIGAENQ KTKVEELLNS
LIGGVLRDAD DGEGWFSKQD KLCGWDRKDL LQGVVLILGK FRDLHRLTVQ YARILDMTLG
DEEKETTDEG MEVED
