ID   HIR1_PHANO              Reviewed;        1044 AA.
AC   Q0UNC6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; ORFNames=SNOG_06738;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT85389.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH445334; EAT85389.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001797101.1; XM_001797049.1.
DR   AlphaFoldDB; Q0UNC6; -.
DR   SMR; Q0UNC6; -.
DR   STRING; 13684.SNOT_06738; -.
DR   GeneID; 5973991; -.
DR   KEGG; pno:SNOG_06738; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   InParanoid; Q0UNC6; -.
DR   OMA; RGSWDGD; -.
DR   OrthoDB; 685536at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1044
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286415"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          68..108
FT                   /note="WD 2"
FT   REPEAT          115..154
FT                   /note="WD 3"
FT   REPEAT          157..196
FT                   /note="WD 4"
FT   REPEAT          218..261
FT                   /note="WD 5"
FT   REPEAT          267..325
FT                   /note="WD 6"
FT   REPEAT          329..370
FT                   /note="WD 7"
FT   REGION          419..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..473
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1044 AA;  112713 MW;  8FAC4C4D658E7666 CRC64;
     MHLIKPQWLT HPGDLKDFEV YSCHVSPDGS RLVTAAGDGY VRIWSIDAIL NSHDPEYKKP
     KQLAAVSHHS GTIHAVRFSS NGKYLASGAD DKIKGTGTNE APPVENWRVI RRLIGHDNDV
     QDLGWSADSS ILVSVGLDSK VVVWSGHSFE KLKTLSNHQS HVKGITFDPA NKYFATASDD
     RTIKVYRFNS PPPNATQQDQ VNNFVLEHTI TTPFLTSPLT TYFRRCSWSP DGAHIAAANA
     TNGPVSSVAI LDRGTWDGQP SQTSLIGHEG PVEVTAFSPR LFYQQQPRVE HDGNIHQPTV
     TVVACAGQDK CLSIWNTVLA RPFMMTQELA AKSITDMAWA PDGEKLFATS LDGGILTMVF
     EPGELGFPAS LAENEKTLSK FGAGRRVGII EGTDALLLEE SSKSGELKGV QGRMGALMGD
     GGAVQPPITN GANGIVPSTT LTNGSSSTAP AAAPAPAPAP APAPAPAPAP AEPPVDQRVE
     KLKQRVTVTK EGKKRIAPML VSSSSGVGTS SLPQTQLISA KTTSGARSDN PHNILDLSKP
     YDGFPKGGLA SMLIGNKRKF AEIEGDEDRQ VERRLAASVR PGGAAVVLNS ESGLIPPAAA
     ASKSNDVAEP SKVLRPAIIS PSLSVSQVRL AVPKVRSVIT RTADGSEPQR NGVDANTGKA
     EIPDTVMLEA RNATGHSRTG RAQDHDPAKI SCTSKGQPLW QDFLPKSVLL VTGNTNFFAA
     ACEDGSIYAW SPAGRRTLNA MVLDAQPVIM DCRGWWLMCI SAVGMCHIWN LKTMSAPHPP
     ISLAPILDIA AHTQGPHLTR SPGIVFARLN SAGCIVVAMS NGEGYVYNSS MYIWQRISEP
     WWSVGSQYWN TTDSSVSNIR SSQDKAAPKE KDDQVSIENI SAGIIPALER NTTNQFLLQG
     RAFYLQRLIK ALISAEGYET FESSVSVAHL ENRVAAAKTL GAREEFKIYL SMYVKRLGAE
     GLKGKIEELL RSLTGDLIVE EDEESGEQQE EIICGWKREE LLKEAVLILG KHRDLQRITV
     PYARLLGIVT EDQRQDEQAM ITDM