HIR1_USTMA
ID HIR1_USTMA Reviewed; 1017 AA.
AC Q4P4R3; A0A0D1BZ49;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; ORFNames=UMAG_04900;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CM003154; KIS67027.1; -; Genomic_DNA.
DR RefSeq; XP_011391225.1; XM_011392923.1.
DR AlphaFoldDB; Q4P4R3; -.
DR SMR; Q4P4R3; -.
DR STRING; 5270.UM04900P0; -.
DR EnsemblFungi; KIS67027; KIS67027; UMAG_04900.
DR GeneID; 23564936; -.
DR KEGG; uma:UMAG_04900; -.
DR VEuPathDB; FungiDB:UMAG_04900; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q4P4R3; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 685536at2759; -.
DR Proteomes; UP000000561; Chromosome 15.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1017
FT /note="Protein HIR1"
FT /id="PRO_0000286416"
FT REPEAT 18..57
FT /note="WD 1"
FT REPEAT 72..111
FT /note="WD 2"
FT REPEAT 131..170
FT /note="WD 3"
FT REPEAT 173..212
FT /note="WD 4"
FT REPEAT 221..261
FT /note="WD 5"
FT REPEAT 267..316
FT /note="WD 6"
FT REPEAT 320..359
FT /note="WD 7"
FT REGION 387..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 110888 MW; 95F24F6AD4EBA3E8 CRC64;
MSIILPDWVA HHNDDKKGKL STIFSVAVHP DSSRLATAGL DTKIRIWATA TILNPRAENN
SNSHRLLSTL SRHTGSVLVV RWANSGRFLA SGSDDTVALI WDLDPSGMGG GSFGSSEVNI
ESWRPYRRLA GHESDVVDLA WADDDEFIAT VGLDSKVIVW SGTHFDRLRI IDGHQGFVKG
VVFDPLGQYL ATASDDKTVK VWRTSDWGLE RSITDPFLTS PSTAFFRRPS WSPDGSLLLC
ANAMSGPVFV ASVVKRSSWS SDIYFVGHEN AVVVTAFSPK IFVGFDGGTH SCVVALGSLD
QSVSIWVTGL EQPVLVARDV FERQVMDLSW SADGYTLYAC SSDGTVAVFH LSPELISDAL
SAEKLEQSRA KHGVKRVRNV AAATNGALPI GTSDRPNMLQ PRKAGQSQAA RASVPPVPIA
GSVPPVRPIA SRTERLHQTI TITKDGKRRI RPTLIGDDLE PSQAVSHHHA YQPAPTSHAL
MPSIQQHQLP AMREAIGGTT VDGFGARPGV NGIHAGMTNS VSDGTAAAVV EAVLAAQRSN
PAAMTTPMAA ASSMMPYVPI GLPFGIMPEG ASPEDMMQFW TEFQQRFMRG KKRKAEDAEA
GSDSDDIEPI GKLQKGKTRA DIGRTLGSEH PRDPPGPKKV LREALTGASG IVENGVRKGV
HLAVPETLSI YRRDEDGLSI EIRNFDESRP TEIARLDPSD KDRVLWLDFS PTAATLATAT
SFFSAVALED STVLIYSSRG GRIGNLLLDS ACYRLESNGV VLMAVTVAGL MYRWNIRADH
EIHRPVSVLN LLGDPENLFS ITVHANGAPI VILQSEKAYT FDDKKLGWVC ISDGWWAEHS
EAWDGRTRSR GSEVSVRDPV RAIEAEINTM YVRRVHGDNQ VGAQEESDDD QTPPVEMSVP
EDKKSDFVIA VTLRHLEARI LAATILDSAN EYKNHLIAYA KRIAEEGIKN QAEDLIKSLI
GPIYYKPEKN QDAAWQPTIL GFDKRQLCGQ VLQILARPRN LTSLVQPYQE ILANMKA
