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HIR1_YARLI
ID   HIR1_YARLI              Reviewed;        1058 AA.
AC   Q6C553;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; OrderedLocusNames=YALI0E20933g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79804.2; -; Genomic_DNA.
DR   RefSeq; XP_504209.2; XM_504209.2.
DR   AlphaFoldDB; Q6C553; -.
DR   SMR; Q6C553; -.
DR   STRING; 4952.CAG79804; -.
DR   PRIDE; Q6C553; -.
DR   EnsemblFungi; CAG79804; CAG79804; YALI0_E20933g.
DR   GeneID; 2911845; -.
DR   KEGG; yli:YALI0E20933g; -.
DR   VEuPathDB; FungiDB:YALI0_E20933g; -.
DR   HOGENOM; CLU_004372_3_0_1; -.
DR   InParanoid; Q6C553; -.
DR   OMA; RGSWDGD; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1058
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286417"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          82..121
FT                   /note="WD 2"
FT   REPEAT          142..181
FT                   /note="WD 3"
FT   REPEAT          184..223
FT                   /note="WD 4"
FT   REPEAT          239..282
FT                   /note="WD 5"
FT   REPEAT          319..364
FT                   /note="WD 6"
FT   REPEAT          368..409
FT                   /note="WD 7"
FT   REGION          49..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          591..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1023..1058
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..696
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1058 AA;  114207 MW;  55E550286125C4F2 CRC64;
     MYIVKPSWLC HSDDQKKFEV YSVTVSPDNQ RVATGGQDGK VRIWSAQSIR DSAKGDNESS
     DTPSNLSGAP APGAKQLCSM ATHNGAVTVV RFSPDGRYLA TGSDDRVVLV WERDSTKVPR
     KEFGSSGEAD TESWIVRKRL AAHDNDIQDL AWAPDSSILV TVGLDSGVIV WSGTTFEKIQ
     RLDAHNSHVK GITFDPANKF FATASDDRTV QIFRYNRASA TDVTFSTEAT ITSPFKQSPL
     STYFRRCSWS PDGNHIAAAN ATNGPVSVVA IINRGTWDSD ISLIGHEAPC EVAAFCPRIF
     ARTKEAAEKK DKKSSSEKDK ESDVIDVDAE PKVPESVPIT VIASAGQDKT LTIWNTSNPR
     PVVVCHDMAL KTITDLAWSQ DGMSLFATSL DGSISYVQFE EGELGYVVSM EENESRLTRY
     GGGKEAAQIP ESVEQLVLEE KVEAKEVKDS EKRMEELMGA AGAGSKAIAS GATVIPSPAS
     TVAAAAAAPV TTTARATTPL TAATSNPSTP AKPAKQKVTI TKDGRKRVAP QLLTTTSSSV
     QGTLPAATTS SAAVPVASAT AETIPVNDFS KPSYALPKGG VSTLVIGSKR RSDDLEDGSN
     GIQTALKKTR PDDDVPEYIA PVVVSPATTT SQVRLGAPKV RNLLMRSMTV RDAEKPRMAN
     ESVSLANGEN TSSSSAPHSF NFEVRNGSGN DQTPTKVSVT RNSQVVFVDF VPYYVHLIAG
     NGCYFWATSA EDGSIVVYSP NGRRMLPPLV TGAPLSFLES QNEYLLAISS VGMLYLWNVV
     DKKAVFPPVS LAPILDSGSR YEDGGVLRGP HVTQCGVTGS GRVIITLSTG CGYTYDEGLR
     SWCRLSEPWW ATGSQYWSAT QLLGDESAKS RWVLAVEERT AEEAQRRAGG RGRYLKQLTR
     ATLNREGYEG MEGVVSIAHL ENRIAAAEML ESKHELRTFI IMYARRIAEE GLRSRVDELC
     RELLGPGKSQ DSTWSPTVCG LDKHELLKEV VLKIGKYRES QRVAVVYGQA IGLLEDEVLG
     VASSSKSAAS KGSKDKEDNE EEDGDHDMTD FKDAMSEQ
 
 
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