ID   HIR2_ASHGO              Reviewed;         850 AA.
AC   Q75C29;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Protein HIR2;
GN   Name=HIR2; OrderedLocusNames=ACR088W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 433-437.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51314.2; -; Genomic_DNA.
DR   RefSeq; NP_983490.2; NM_208843.2.
DR   AlphaFoldDB; Q75C29; -.
DR   SMR; Q75C29; -.
DR   STRING; 33169.AAS51314; -.
DR   EnsemblFungi; AAS51314; AAS51314; AGOS_ACR088W.
DR   GeneID; 4619617; -.
DR   KEGG; ago:AGOS_ACR088W; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_1_0_1; -.
DR   InParanoid; Q75C29; -.
DR   OMA; RGSWDGD; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..850
FT                   /note="Protein HIR2"
FT                   /id="PRO_0000286418"
FT   REPEAT          5..46
FT                   /note="WD 1"
FT   REPEAT          61..98
FT                   /note="WD 2"
FT   REPEAT          110..149
FT                   /note="WD 3"
FT   REPEAT          151..190
FT                   /note="WD 4"
FT   REPEAT          255..299
FT                   /note="WD 5"
FT   REPEAT          303..342
FT                   /note="WD 6"
FT   REPEAT          519..557
FT                   /note="WD 7"
FT   REPEAT          558..596
FT                   /note="WD 8"
FT   REGION          354..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  94529 MW;  F23C0124621E9490 CRC64;
     MKLLKYPRQL HDGQLLAGCV VGGLLVVVGR DRISAYDCGK LQAAARGELA VREVSAEVEL
     QVEVGEDALR YVAGGEGELV VAGDRQIWAA GADWRSAGRG TRFLTVAQLA GGACVTDVKA
     DGAGLVFVSV SGKDEVWLYA TGAWERVGVV TLAAKPVTLV VDPLGELLTV VLQNRSVAVY
     QYNRQGAVRM HQQLPQYVQT NPLRYSITMS PQGDLLPLVN SIKNGLPSAQ LLDRTAGFSV
     QSTLVGYVDK CKILRFSPRL YEKPNKDKPP TQYNLLASSG NEDGSVIVWN TKRTKPLLNA
     AKVTDTFIND VQWSRDGTGL FAISNDGYLF IFAFHEVELG RLLDDAELEK LRQSVPRLEP
     LPPPTPKSLA KSEAKPQQDT KPDAKSSANS VSAKTGKKKI APTVITSTSM EFNEPSYTVP
     KDLKRRPKQE TQTNGTTTKR PKRDVEPMDF LDTNLLIPNI SFSKARLATP KVRMNFQYCN
     TLQQNLVMEV KNGTGSEQKP TSITLTLKDK EKDMVLFQDF TPRFVTICTC GHSFWACCTE
     EGIVYVYSNT GKKLLPPMIM GVPVSFLEGC GDYLLCVTSM GQLFCWNVKE GKLKFPVNTI
     YPLLNPSIRY SDDVLTRAEN ITMCTTTENG IPLVTLSNGD GYMFDPDMEI WLLINDSWWA
     YGSQYWDFTN TSHAGSSAAA GNDKEDKKNK YWNADAEYLI EEVKKNKKSV VNYLESKTND
     EMTRKGLIRN LQRFAKTILM KEGFENLEDI VTLSHLENRL LVALKLNETN EFTKLLKVYC
     ISLAEMGFKN RLDDVLSWLY NDGEYKVGTI ANEKREELLK QILVACADIR QVQRVTTSYA
     SALGLLDVSL