ID   HIR2_CANAL              Reviewed;        1017 AA.
AC   Q5AGM0; A0A1D8PNI8; Q5AG84;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Protein HIR2;
GN   Name=HIR2; OrderedLocusNames=CAALFM_C502750CA;
GN   ORFNames=CaO19.11771, CaO19.4295;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CP017627; AOW29700.1; -; Genomic_DNA.
DR   RefSeq; XP_720603.2; XM_715510.2.
DR   AlphaFoldDB; Q5AGM0; -.
DR   SMR; Q5AGM0; -.
DR   STRING; 237561.Q5AGM0; -.
DR   PRIDE; Q5AGM0; -.
DR   GeneID; 3637740; -.
DR   KEGG; cal:CAALFM_C502750CA; -.
DR   CGD; CAL0000181007; orf19.11771.
DR   VEuPathDB; FungiDB:C5_02750C_A; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_3_0_1; -.
DR   InParanoid; Q5AGM0; -.
DR   OrthoDB; 685536at2759; -.
DR   PRO; PR:Q5AGM0; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1017
FT                   /note="Protein HIR2"
FT                   /id="PRO_0000286419"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          74..117
FT                   /note="WD 2"
FT   REPEAT          124..163
FT                   /note="WD 3"
FT   REPEAT          167..208
FT                   /note="WD 4"
FT   REPEAT          228..271
FT                   /note="WD 5"
FT   REPEAT          275..326
FT                   /note="WD 6"
FT   REPEAT          330..371
FT                   /note="WD 7"
FT   REGION          417..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..458
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1017 AA;  114476 MW;  B2F3A1609DBE39D7 CRC64;
     MKFLKLPQSY HNGGIHSIDV NQDNTILVSG GTDNKIGVWN LKKLIELSKL VSTHNSPEVR
     LKLKSLEPKQ YITCHKSLIN VVRFFKGDNK RFISSDVNGN VFFHTLHEQP ETKQLFPFKS
     IETSEVNPVV DLTISADNRL IAWSTNNGKV YLYDVVKDTF QELTSICHEK PIIQRSIAFD
     PSNNYLITVG DDTQINVFQY SYEKDDTSTT TYKFRLIYKI SKLFSQNPLN VRYKRISWSP
     DGNLVSIPTA SKNQTMLISL ISRSEKWTNI ESLVGHDFAC DVVKFNPKIF SSKENDTSKV
     HSVIASGGSD RTMAIWNTSK STPITVLQDA VQGEILDITW TTDGTSLLFC TSQGKLCIGN
     FEPNELGYTF SQETMERFVQ LQNNLIEPMN FRYPHEQTVG NRKQLPPIEF LSQKNAISTT
     TSSSNTVEND KKNAEDNVGV SNQSKSTTTT TTTTIKGGVI TPEVIPPPKL QSLDDDIDGD
     GDDEEHKSGG MLDSVMNDRT QSSPRKLNKP KPIAPVVSDS TTQSLSFNKQ KVTTKNGKRR
     IQPMLISSGN SAPSDLPRSN SVIKPVVNTT KSTMEFEKPS YSVSEEFYKQ NKRPRTEETT
     GSNNNKKLKR EMEPVKFIGS VILNPNTSFS KIRLATPKVR LFFQLKSKTD DDGVFILDIK
     NGSGNESKPS RLTYMKKDKE IWCDFIPKYI QLATEGSNFW AVTTVDGTIL TYSHVSGKRL
     LPSIVLGSPI SFLESYDKYL MVVTCIGELY VWDMEIKKNV LKSSISPLLE LYNKEGLVKS
     DNITLCAVTS YGIPLVTLSN GSGYLFNKDL GVWQTITESW WCFGSHYWDS TQTGNSSGGG
     GGSGGSNNKR SLQTMNMFND EQSIIELLEH KTNEEILRKT RTGRGKYFNK ISKNMLMKEG
     FESLENTISI SHLENRILCC ELLGENKDFH KFFTTYVQRI CELGFKAKLF EVCDELLGPI
     DTDTAKPPNE NNWEPKICGF DKRELLKEII TSCSQFRDAQ RVLVHFGKKI GVVIDES