ID   HIR2_CANGA              Reviewed;         997 AA.
AC   Q6FR48;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Protein HIR2;
GN   Name=HIR2; OrderedLocusNames=CAGL0I00968g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380955; CAG60233.1; -; Genomic_DNA.
DR   RefSeq; XP_447296.1; XM_447296.1.
DR   AlphaFoldDB; Q6FR48; -.
DR   SMR; Q6FR48; -.
DR   STRING; 5478.XP_447296.1; -.
DR   EnsemblFungi; CAG60233; CAG60233; CAGL0I00968g.
DR   GeneID; 2888912; -.
DR   KEGG; cgr:CAGL0I00968g; -.
DR   CGD; CAL0129945; CAGL0I00968g.
DR   VEuPathDB; FungiDB:CAGL0I00968g; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_1_0_1; -.
DR   InParanoid; Q6FR48; -.
DR   OMA; GELYCWD; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 2.
DR   Pfam; PF07569; Hira; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..997
FT                   /note="Protein HIR2"
FT                   /id="PRO_0000286420"
FT   REPEAT          10..48
FT                   /note="WD 1"
FT   REPEAT          117..152
FT                   /note="WD 2"
FT   REPEAT          153..194
FT                   /note="WD 3"
FT   REPEAT          274..319
FT                   /note="WD 4"
FT   REPEAT          323..362
FT                   /note="WD 5"
FT   REPEAT          665..706
FT                   /note="WD 6"
FT   REPEAT          708..745
FT                   /note="WD 7"
FT   REGION          408..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..518
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..584
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   997 AA;  110772 MW;  95EAC4CC23D3FB42 CRC64;
     MRLLKYPLEG ISGNVTSLVT IDAEYVVVCG SRGDIQVWHQ QQLLDTAFDR CTLETLKPKY
     SFTFELKDDE DELVFAMGDR DCLYLGTEHS VYSYSGWLKA LESGHTTLEN KLIYTTVSQS
     IITDVKWDSL LDILFVLTDR PCKIHLFDTR SANKKEITSI ALDKNSKPLT GVVDPSGAGT
     FTVLTSDRSI VVYHINRTGD YKEVKKLSQH VLVYPLHYKI TMPPQADFLP IINSLKGSSG
     AAGSTATVLL NRNENYKVMS TLVPSASSNT KVLVHSPKMY EKANLKRGTI SRYNLVATST
     NTDGSIMIWN TKRGKPLFAP LNISDSAIND MIWSSNGLTL FAVSNDNVLY TFAFLQDDLG
     KTVPMEEIEN IRQSNIIKEP LPIAYVITAS DGLGDISTSK NQGLGVAADN SSNILSTDTN
     TNEKNLSTVN TTEPQTNSQS SSYNNKPESK LDSSKSEITS ADSSDEKAKN LEARPIEAKS
     KKILNGKNLE SKSSSVTTSD NIQKKVEDSK SNVSVTATEK KTKPDKKSIK SENGESKVNK
     AQNTISPKES NTTDNKSTTP DFKNPSYQVP KDLKRKPKED ALGNAVTKRA KKDLEPVDFL
     DTGLLLPNVA FSRVRLSTPL IRMNIDCTSS NDSKILLNIR NGSGNEQKPT IVKLLDKTVT
     PERTLFQDFI PKFVSLATSG DDFWACSSED GTLYIFNDVG RKIIPPLTIG VPISFLEACG
     KYLLCVSSIG ELYCWNIASS KLEFPVTTIF PLLSPSIRYS DDILTRAENI TMCSVTNNGF
     PIATLSNGDG YMYDKNMETW LLVSDGWWAY GSQYWDSTNN SNLIPDSSTK PTEGQSSTEI
     SKASIVTLLE KKTNNELTRK GRIKNLRRFA RTILMKEGFE NIEEIVTLSH LENKLLVTLR
     LEEQHEFKKL IKLYAVKLGE LGYVDRLRDL FAWIISDSND NGDLIPGINR KELVKTLLTA
     CADLRSVQRV TIDYADMLGY LPNDIFFDCE SQNDTGK