HIR2_DEBHA
ID HIR2_DEBHA Reviewed; 994 AA.
AC Q6BIR7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Protein HIR2;
GN Name=HIR2; OrderedLocusNames=DEHA2G08184g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG90367.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR382139; CAG90367.2; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_461904.2; XM_461904.2.
DR AlphaFoldDB; Q6BIR7; -.
DR SMR; Q6BIR7; -.
DR STRING; 4959.XP_461904.2; -.
DR PRIDE; Q6BIR7; -.
DR EnsemblFungi; CAG90367; CAG90367; DEHA2G08184g.
DR GeneID; 2904785; -.
DR KEGG; dha:DEHA2G08184g; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q6BIR7; -.
DR OrthoDB; 685536at2759; -.
DR Proteomes; UP000000599; Chromosome G.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50969; SSF50969; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..994
FT /note="Protein HIR2"
FT /id="PRO_0000286421"
FT REPEAT 10..49
FT /note="WD 1"
FT REPEAT 70..110
FT /note="WD 2"
FT REPEAT 118..157
FT /note="WD 3"
FT REPEAT 164..203
FT /note="WD 4"
FT REPEAT 220..263
FT /note="WD 5"
FT REPEAT 276..319
FT /note="WD 6"
FT REPEAT 323..364
FT /note="WD 7"
FT REGION 413..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 112091 MW; 12C96A30118E25D9 CRC64;
MRVLVFPSVL HSGQIHSIDI NKDNSKILTS GLDKEINVWN LQEFVQLTTE GKDTVKDDIE
NVKPLLRITA HEDLVNIVKW CPQNENVFVS GDIQGKVYMH DISKNTHELI FPFGWKEDGT
SRVVDLAWSD DGRMLAWSSG DCKIHIYDTE KATYQELTSL SNLEKLTVQR SIAFDPTNHY
LISMGDDTSI YLYQYQYEPT TRNYQFRLIN RISKLINKTS MNVDYKRISW SPDGEYVSVP
TASKNQTSLI SLLSRSNGWN NILSLVGHNL DCEVVQYNPM IYNSSENNDN PKLFNVIATA
GSDMTLVVWN TTKDKPIFIL QEISKKPIVD LCWDKTGNSL FVASLDGHLS IVSFHPQELG
NTVSEELWKE LFEAGEASIK PFNEKPDQDI TPSTKKSSHN VIDILDQKNS INVHEAKAKK
PTEGIKDLSS ISPEEENADT ESPLKQDLQA HDKQVTNFVP EVIPAIIEDA PETQTEDILH
SAMSTTRSTK SQVKNPKEKP TKVTPEKAKV TTKNGKKRIQ PMLISSMNEN SSNNSVKKSN
TSESNGTSNL VSSGKVLMEF DKPSYSISDD LYKQNKRTKT QDENSNKKLK RELEPVKFIG
SVVLNPSTTF ARIRLSIPKI RLNFQLSSTV EDNSFILDVK NGLGNETKPS RITYFKKEKQ
IWCDFIPRFI QLVAEGSTFW AVSTADGQIL TYSHTSGKKL LPPIILGSPL SFLESHGNFL
MAVTSIGELY VWNIEQKKIH LQSPSSLSSL LDLSNKYQED GLSKSDNITM CSITNNGIPL
ITLSNGAGYL FNKDLGTWQT ISESWWAFGS HYWDSLGNDD GSKPQSYGLF CDSNDSSIVG
LLEQKTNESI LRKTRAGRGK YFNKISKNML MKEGFENLEN TISLSHLENR ILCCELLGEF
KDFHDFFIIY VKRICELGFK AKLFEVCDQL LGPSEPNSTA TKDGEANWNS EICGIKKHDL
LKEVILSCAK NRDCQRILIH FGKKIGVIDI DEFN
