ID   HIR2_KLULA              Reviewed;         847 AA.
AC   Q6CM99;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Protein HIR2;
GN   Name=HIR2; OrderedLocusNames=KLLA0E21945g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAH00027.1; -; Genomic_DNA.
DR   RefSeq; XP_454940.1; XM_454940.1.
DR   AlphaFoldDB; Q6CM99; -.
DR   SMR; Q6CM99; -.
DR   STRING; 28985.XP_454940.1; -.
DR   PRIDE; Q6CM99; -.
DR   EnsemblFungi; CAH00027; CAH00027; KLLA0_E21847g.
DR   GeneID; 2894607; -.
DR   KEGG; kla:KLLA0_E21847g; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_1_0_1; -.
DR   InParanoid; Q6CM99; -.
DR   OMA; RGSWDGD; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..847
FT                   /note="Protein HIR2"
FT                   /id="PRO_0000286422"
FT   REPEAT          10..46
FT                   /note="WD 1"
FT   REPEAT          113..153
FT                   /note="WD 2"
FT   REPEAT          155..194
FT                   /note="WD 3"
FT   REPEAT          259..305
FT                   /note="WD 4"
FT   REPEAT          309..348
FT                   /note="WD 5"
FT   REPEAT          508..548
FT                   /note="WD 6"
FT   REPEAT          558..597
FT                   /note="WD 7"
FT   REGION          368..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   847 AA;  95720 MW;  4B96108350629518 CRC64;
     MKLLKLPSKL HDGQLTQCEV DDNKLYIIGG KYLSIWDSQT LLNAATGKTD VKEVKELEKM
     SLDLLESNQE DGRWLVVLDN QRLVYGSDHL LACLDLNKDS NSEYKSREIG IFKDNEAITD
     LKYDKVNGLL FVSLSKANSL QIMDSKTWEL KSSIELKSKP ISIITDPLGQ LLTVILQNRS
     VQIYQYDSHG TTKLHQSINQ FVQTNPLPYR MTMSPQGDVI PMINSLHNNV PTAVLLDRIQ
     KFKIKLSLVG YVADCKILKF SPRIYSKTKS PTSNDTQTFN LLASSGNEDG NVVVWNTNRI
     KPLFDASKVV NSYITDLEWD NSGLGLFAIS QDGQLVIFAF QENELGDVMP VEAVTEAAKE
     IKLLDPLPFK PKAEEPDTKL PPNKTAQQTT TNSKKQPKAA EITTISSTNM EFIQPSYMVP
     KDLKRKPVTE DPLLAQNKPA NKKAKKELDQ IDFLDTNLFL PSVSFSKVRL AHPKIRASFQ
     YSSQGNFVLD IKNGLGNDQK PTSITLTRKD NESSKQLFQT FLPKFVTLCS AGSSFWAWST
     DTGMIYVTSI SGQMLFPPML LGVPVSFLEG SGDYLLCITS IGQMYCWNVN TGKIAFPIND
     VYSLLNPMLR YSDDVLSRAE NITMCAVTSQ GIPIVTLSNG DGYMFDSAME AWMLINDSWW
     PYGSQYWNFM SSAGVDLTSN DDEKKDKYWN AEADILAKEV KNNKNSIINY LETKTNDELT
     RKGRMKHLQR FAKVLLMKEG FENLEEMITL AHLENKILVS FRLKEVEEAI RLLKIYCIRI
     AEMGYTDRFS QTLSWLYDPT NTKFSPLDID RRRNLIKDII ISCANIRQVQ RVTTSYANEL
     GVISDSL