ID   HIR3_ARATH              Reviewed;         285 AA.
AC   Q9SRH6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Hypersensitive-induced response protein 3;
DE            Short=AtHIR3;
GN   Name=HIR3; Synonyms=P31; OrderedLocusNames=At3g01290;
GN   ORFNames=T22N4.8, T4P13.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=15060130; DOI=10.1074/mcp.m400001-mcp200;
RA   Marmagne A., Rouet M.-A., Ferro M., Rolland N., Alcon C., Joyard J.,
RA   Garin J., Barbier-Brygoo H., Ephritikhine G.;
RT   "Identification of new intrinsic proteins in Arabidopsis plasma membrane
RT   proteome.";
RL   Mol. Cell. Proteomics 3:675-691(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=17644812; DOI=10.1074/mcp.m700099-mcp200;
RA   Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J.,
RA   Barbier-Brygoo H., Ephritikhine G.;
RT   "A high content in lipid-modified peripheral proteins and integral receptor
RT   kinases features in the arabidopsis plasma membrane proteome.";
RL   Mol. Cell. Proteomics 6:1980-1996(2007).
RN   [7]
RP   INTERACTION WITH RESISTANCE PROTEINS, SUBUNIT, AND SUBCELLULAR LOCATION.
RA   Qi Y., Katagiri F.;
RT   "New classes of proteins forming complexes with resistance proteins.";
RL   (In) Proceedings of the 20th international conference on Arabidopsis
RL   research, abstract#501734213, Edinburgh (2009).
CC   -!- SUBUNIT: Self-interacts and forms heteromers. Interacts with NB-LRR
CC       class of R proteins before R proteins (e.g. RPS2 or RPM1) are activated
CC       by the effectors. {ECO:0000269|Ref.7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15060130,
CC       ECO:0000305|PubMed:17644812, ECO:0000305|Ref.7}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:17644812,
CC       ECO:0000305|Ref.7}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC008261; AAF26146.1; -; Genomic_DNA.
DR   EMBL; AC010676; AAF03497.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE73633.1; -; Genomic_DNA.
DR   EMBL; BT024707; ABD59045.1; -; mRNA.
DR   EMBL; AY084426; AAM61000.1; -; mRNA.
DR   RefSeq; NP_566135.1; NM_110995.3.
DR   AlphaFoldDB; Q9SRH6; -.
DR   SMR; Q9SRH6; -.
DR   BioGRID; 6642; 9.
DR   IntAct; Q9SRH6; 6.
DR   MINT; Q9SRH6; -.
DR   STRING; 3702.AT3G01290.1; -.
DR   iPTMnet; Q9SRH6; -.
DR   SwissPalm; Q9SRH6; -.
DR   PaxDb; Q9SRH6; -.
DR   PRIDE; Q9SRH6; -.
DR   ProteomicsDB; 230225; -.
DR   EnsemblPlants; AT3G01290.1; AT3G01290.1; AT3G01290.
DR   GeneID; 821309; -.
DR   Gramene; AT3G01290.1; AT3G01290.1; AT3G01290.
DR   KEGG; ath:AT3G01290; -.
DR   Araport; AT3G01290; -.
DR   TAIR; locus:2100242; AT3G01290.
DR   eggNOG; KOG2620; Eukaryota.
DR   HOGENOM; CLU_024949_5_1_1; -.
DR   InParanoid; Q9SRH6; -.
DR   OMA; TQIKAYV; -.
DR   OrthoDB; 1237942at2759; -.
DR   PhylomeDB; Q9SRH6; -.
DR   PRO; PR:Q9SRH6; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SRH6; baseline and differential.
DR   Genevisible; Q9SRH6; AT.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0002239; P:response to oomycetes; IEP:TAIR.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Coiled coil; Lipoprotein; Membrane; Myristate;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..285
FT                   /note="Hypersensitive-induced response protein 3"
FT                   /id="PRO_0000398598"
FT   COILED          113..139
FT                   /evidence="ECO:0000255"
FT   COILED          165..185
FT                   /evidence="ECO:0000255"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  31321 MW;  57A46F2A29CFB74C CRC64;
     MGNLFCCVLV KQSDVAVKER FGKFQKVLNP GLQFVPWVIG DYVAGTLTLR LQQLDVQCET
     KTKDNVFVTV VASIQYRVLA DKASDAFYRL SNPTTQIKAY VFDVIRACVP KLNLDDVFEQ
     KNEIAKSVEE ELDKAMTAYG YEILQTLIID IEPDQQVKRA MNEINAAARM RVAASEKAEA
     EKIIQIKRAE GEAESKYLSG LGIARQRQAI VDGLRDSVLG FAGNVPGTSA KDVLDMVMMT
     QYFDTMRDIG ATSKSSAVFI PHGPGAVSDV AAQIRNGLLQ ANNAS