HIR3_ASHGO
ID HIR3_ASHGO Reviewed; 1643 AA.
AC Q75DV4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Histone transcription regulator 3 homolog;
GN Name=HIR3; OrderedLocusNames=ABL081W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 771; 926; 942; 1262-1267;
RP 1277; 1309-1311; 1347; 1357 AND 1365-1368.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC for the integrity of heterochromatin and proper chromosome segregation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016815; AAS50690.2; -; Genomic_DNA.
DR RefSeq; NP_982866.2; NM_208219.2.
DR AlphaFoldDB; Q75DV4; -.
DR STRING; 33169.AAS50690; -.
DR EnsemblFungi; AAS50690; AAS50690; AGOS_ABL081W.
DR GeneID; 4618947; -.
DR KEGG; ago:AGOS_ABL081W; -.
DR eggNOG; ENOG502QQX4; Eukaryota.
DR HOGENOM; CLU_001316_0_0_1; -.
DR InParanoid; Q75DV4; -.
DR OMA; WETWYRL; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR InterPro; IPR033053; Hir3/CABIN1.
DR PANTHER; PTHR15502; PTHR15502; 1.
PE 3: Inferred from homology;
KW Chromosome partition; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1643
FT /note="Histone transcription regulator 3 homolog"
FT /id="PRO_0000256193"
FT REGION 311..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1598..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1598..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1643 AA; 189140 MW; 5D36E38F7898C874 CRC64;
MSLFTALNST PHDALLEAEE HSRELQVEES FRVFQSALFH LKAKRFDDAE AKFEQLFNIE
VLKPDHWGLY RYSSPTLDLL RYLAYRNRGV FYYQYVREHA EELDKDDIVD YILKVVENLL
QALQHSDGDA AVTGLLLQVF RGFKSKRLQR WILEYELTKQ PEEMLLLGRG RALLPDTRGL
VEEYRRVLRD VRSEPVTEFA ARVLTLVKTD SLEVQPLPPV LDKIEQLKDE DDAMMKQLAE
YEVNLEELSW ECIAESFRSL VPKYKYTNFF SKAPDPYSEA GDPIECIKFV HNDKPIEQEV
MEQLSVQNER EPFAATQAAT EAPTLEKEGS ENGGRTESKR DSELPSDSQR PAQRSSKRFK
ERSTETNEAE LLRPHQDFAA LFYSCTGILE VRLEIELSHL NPEAIPSTYP AYMPMLDFYE
CLNSWTSKHT EFLNQSETKG TSKNKGKGED SFQLTSLLRS SMFTEENRPT ISLTELPYKE
VAEFISTVNS NRLHFHAVRL LLLQVLLTVR PDGSCLITDT FWSPILYDTI ESFVLSLESN
IYDLVYSQSE KYKGLGLSFC EVLMNSLGGI YTEIHAKKIS GGKYGELEAQ KNKLEKKIDR
WVLLLDQLVF EGKLKFRYLW SKFCYLQCIS DVTDDRIIHS LDYITHELRN SSMDIDISYA
NYEHTPRLNM ETVQSQLSKI KMMRKFTMVN QMDVDRNDSS NEDQIEALSR VLVGTSLLDT
PEDRSMSEFV NQAPFLLKIK LWRIVLHHYL AVKDQSNFQI CYFKVLHVLY ERLCSKEYSD
QSQLQRQQTL LSTLSLMRSF TSLFIELLSG ANEWVINDTS QASEYFKLLI DVFILLYPLT
YFETLSQKSA TTVSFFKKAA KSSVILKDMF VDISCLLVLY FTGACTQKEV VNGVEVATEF
IHALHLLIGG FTFCDAANGN FLNLAEHFFC SVEGSSSFIP LKQILLCKYR LSLGGDANSF
EDHGAKPQVL EMHNAVRLAK YLIRFEYQNK NPYLISTNRS NLKQVIENVI DVIGKIPYAE
NHILARNVYY FEQYLEAPVT AKIIQEALQG CISIELTKPR DNLQEIVDLG LYYISGVQLL
NLYKVRKKTL QARPSELDSI IETLKADILY KTNRFETWFL LGKCYSYVVE DDLIWTSDRL
VVASKKATTA SIQRKAILCY LMALNLCQLS VDDPSLSEAQ KMENAFIKRE IYEVLALELL
NAYFKPMEGL PFQRDIAPAL VLTETGELVE PKNSPQPSIS SANIYRATLL VFTNADEMYK
DSQDALQNWL NPHYIANLRF KHEREDFITD GFDIIIRACN LAMKASTSND NIIEPHYSLV
IKCYKSVKHG WLRPEDALKH LLNDNSFLAQ EANFYSHNPE NSVQDFYRKI ITLLRRLLAL
DKRKWHHRPT YRIARILFDD FNDVDGAIQE MGVLMALKSV NKNLVNIWKP EYERPGKHFV
YTYQYVMFYL KLLSHKNDYI SLGHAARKMR RFGSGMVNGS LATDKAVEMF INGARAALGI
NEKEHAELLL PTLNYQAFNR YSDELIASFN KENYSYEVLE SLAISYQLKK GSSGIAFDGV
CLSIYFKYLY LPWVEEHEAA EATQSMVKFV EINKNVNPTE NETASPQPAA EPQKSTTKQV
SSRKRVSKKD AFDKISQIVD KIT
