ID   HIR3_ASPFU              Reviewed;        2019 AA.
AC   Q4WYF1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=hir3; ORFNames=AFUA_3G12810;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92302.1; -; Genomic_DNA.
DR   RefSeq; XP_754340.1; XM_749247.1.
DR   AlphaFoldDB; Q4WYF1; -.
DR   STRING; 746128.CADAFUBP00003558; -.
DR   PRIDE; Q4WYF1; -.
DR   EnsemblFungi; EAL92302; EAL92302; AFUA_3G12810.
DR   GeneID; 3512509; -.
DR   KEGG; afm:AFUA_3G12810; -.
DR   VEuPathDB; FungiDB:Afu3g12810; -.
DR   eggNOG; ENOG502QQX4; Eukaryota.
DR   HOGENOM; CLU_001419_0_0_1; -.
DR   InParanoid; Q4WYF1; -.
DR   OMA; WETWYRL; -.
DR   OrthoDB; 72175at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15502; PTHR15502; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..2019
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256194"
FT   REGION          319..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1780..2019
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..407
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1803..1821
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1846..1876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1885..1912
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1927..2002
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2003..2019
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2019 AA;  229303 MW;  05DC85F2A20D47DC CRC64;
     MSSWVALNIE PDEAIEEEVD DTKEIQIEEA LKLYQNALKL HSQGPQFYAQ AAEAYEALLS
     SDIFKYPESI SDFKRSALQD SEAHLDDDVA VIDAVETFPE FSVNDSTSST LLQTIYLSYK
     NHGQFTLDTL QAFLQENPRT SDKAQEILSQ VSKRTHAALA SFAEALERDD TDLNLWRRSA
     RLSNALQSYR LVRYCLESVL ADDENCLEVR TDQLGLDETF AQGQLRETLQ ALDDNLSVSQ
     VPLKKPKKAL LRFLERQKDP YPYLPALPSH VRDEDPSKNP LAIRASCYQL TPASHTWAAV
     GDSILQALID MERDASKFGP GTSIRFSMPE STADLRSSTA GEVADQDQSS HMENGESANH
     IPEEDVDIAN TTESAAPKTL RKDQDASSIL EHVDDQSSID QRAEKQLMES LENQSARQND
     ATTVQDVPNV DEVEPNPSSA GRKRPSASAA NEDYQAEPVR TKSRRTRLRD SIAETSLQSD
     EVSFDQNKYY EDRLQTYVEA DEWMFDTVGP LLSKLGVDKL ESLDELRRQS AANCSKSSVE
     RSSNQPTSAV HVLYRDLDSI VKTWDEAKSQ AMLQDDTSLT FQDMKAMDNS GLTIFLEHSR
     KSARKTGLKP SFTDDKVLSK FLKGVNEEWL HLHEVGFAWL KLLLMPVYGK SPVRKNSRSK
     KWPVMESAYV AFQWPDVLKE KVVQLLVRDD EYIFRKMREQ AEQTELQILN HTPQTPFKYT
     RDHLAYLEMT QTVFEIHLDV YASINNPHSE VDQDTRLVQR DRLMRWSMLA RTALSHYLDH
     GPSRKDSQNS IILRHIWAST FHSNMEPDVH REHILLCLQD LKEMLHRLSI LEIHLMNNAM
     MPELSADAID QEISKLNSMD FFMKIFTPGS EDPVELIETI EPIVEPSSVE IPEESESNDQ
     SLSQSMVQLK EMRSFLDRGD AMLKLFLWQR LRDAYQAIDY PPKVVSCYLR SVETIIQELL
     GASYLEESNE HREIALIRWL KSLDRILMKL VTLVLQQSDK AYECLDMEHL RSSMSALTTL
     TNLLHSFALY EDSVRVGQTP SSSVRGSLSK SLGNFTEKLR EMEVRCWILQ YTLLKEAITQ
     NGDLFESPLE DRILFLRSVH NALGIRKMCK RSNKQFLKLM KAEFFSLESK EAYESEICQI
     LWDLYGINLS PPGRFLFEHE CPPEKLDRST AIKLVDFVLK LAKRMNIKDL SKSELKSTIE
     KIQQAIGTTK SSPPLTYNKR ILSAYLKSPI NPTEIFRAVR GVADLPLVPV PTESAVIAQN
     GWYFLLGHAA LTKFRSQKRL NPVPTTDLDE AITFFRQDLD HATGRWESWY RLAQTYDSKL
     EEDITWSADK INNNRTELVT WQRNAIHCYA MAVATAIRSA EPTPETRATL SELYTDFGIR
     LYSSSREPLS MAAFSLADFT RHYSNEESQR MYQGKPFKEM RLYSVWNLAR YLLKRATIDK
     PKSWMNHYML SKCLWKMFSC DDSVRGNAQR ISVDDLLDSL LDAIDTLPQR KDSRSDPIFE
     PHYKLVSIVH KLVDRGTLTP AEGSQTLMAT PLARKVQPPE DKAGWKPYIL EVLRRLKHAD
     KSNWHHRMAV RAAHVTYDDT RDTVSAAAAK NELTQQIFTK TMTIQVWRPE FERPGRHFVY
     TTRYVYFFVS LLDQLNDRAN LDQLLRRVRK KQGDFINHTK LWEDVCLTYA KVIRRAGSIN
     EGHEENVFKP IGWEEFVANT ARLENLPQLA PGSQVLLELL RDAIELKKLN NNLMKVSLLE
     DLIADLYSRL YEINMPQVLE QANEENKEKM KVDHLLMASD GAADTPTPPN SAPASEAPAP
     RGRTKGIARR DVQKRAETIV GRKLTPRAPA AKASVPAESE PPATSEPAAP SGNQPNKTSF
     EMGQQSDIPQ SIQDSADDES ELSEIDDEKL SKLAAERKLL FPNLRDRISP DPDSEMSVPA
     SIDGDAADEV GDGDADLNEA EGGGETTVEE GEGEDGEEGD EADLERDEND GDEESLEEGE
     GNGEDTENAQ DMEDEAEEPE VIEGDPPKEN ASEPEPMET