ID   HIR3_ASPOR              Reviewed;        2059 AA.
AC   Q2UBW0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=hir3; ORFNames=AO090012000841;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR   EMBL; AP007161; BAE60955.1; -; Genomic_DNA.
DR   RefSeq; XP_001727794.1; XM_001727742.1.
DR   AlphaFoldDB; Q2UBW0; -.
DR   STRING; 510516.Q2UBW0; -.
DR   PRIDE; Q2UBW0; -.
DR   EnsemblFungi; BAE60955; BAE60955; AO090012000841.
DR   GeneID; 5988268; -.
DR   KEGG; aor:AO090012000841; -.
DR   VEuPathDB; FungiDB:AO090012000841; -.
DR   HOGENOM; CLU_001419_0_0_1; -.
DR   OMA; WETWYRL; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15502; PTHR15502; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Repeat; TPR repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..2059
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256195"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          49..86
FT                   /note="TPR 2"
FT   REPEAT          139..172
FT                   /note="TPR 3"
FT   REPEAT          1029..1064
FT                   /note="TPR 4"
FT   REPEAT          1271..1304
FT                   /note="TPR 5"
FT   REGION          337..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1779..1896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1908..2059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..476
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1802..1820
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1847..1878
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1936..2040
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2043..2059
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2059 AA;  230999 MW;  928531317C629C03 CRC64;
     MSTWVALNIE PAEAVEEEVD DTKEIQIEEA LKLYQNALKL HSQGPAFYAQ AAEAYDALLS
     SEIFKYPESL SDYKRAATEL ELTETSDYVG NADGAEPLGD YDINDSTSST LLQTIYLAYK
     NHGQFVLDSL RAIIQNAAQE SDSTPGLSAE IAERASTALT SFAEALERDD TDLNLWRQSA
     RLCSTLQSYR LARYCLESVL ADDENRLEVR TEQLGLEETF AEERLRETLL SLQDRISVCQ
     VPIKKPKKAL LKFLKRQSDP YPYLPGLPDS LQNVLPSKGP LALSTARHDL KPLSPTWADL
     GKTILQALTD KEQGTIDLGP GTAISVSTPA LSPELKATAT KETQVQDQSP RAQDEELSSD
     PKPITHMSGE DDNNMDFQPS VKHEALDSTA EHADDHSSID QRAEKQLIES LEIQTSQSPE
     LANQQETPNA DDADPKSSTN GARKRSSTSA VAEDQTESVR SKSRRTRLRE SHAEASLQAD
     EVSFDHNKYY EDRLEVFVRA DEWMFGTVES LLSKLGIEDL GSVDELRKQI SPTSDGKDLP
     DSDINGKAEY ILPRDLRHIL KGWDEGKSQA TLQCDNVAAL QDIQGMGKSG LAIFLEHSRK
     SARKLGMKQV LSGIEELLML MNTINDGWFH LREAAFEWLK CLLMPDYGRI SAQDGVFGTS
     NFTIINSTYT LFQWPDTLKE TVVQILIRED ETIYKGVSEY IEALERQILG ASADTPFEYT
     TNHFAYLEMA QAIFELHLDI YASINNPNSE IDQGIRVQQK DRLARWSLLA RTSLTHFMDY
     SSPGSHQDNI VLRHIWASTF HSNMTTDAER EHVLLCLQEL KHLLSRLKDP VISLVNNAIM
     PEISIEAVDQ EISKLESMDF FMRIFNTESE DPVGLIETIE PILEPASVQF VEENTSEEQG
     HSLPTSQLHE MGSFLDRGDA TLRLFLWRRL QDAYRKIDYA PKVVSCHLRS IETIVRELWN
     PEHLEEPSEH RQITLLRWLK SLDGILNKTV TAVLQEPAKA YECFDMDHVK SSLSAVTLVL
     KLLHSFVLYE DSVRVGQLSG SDVRGALAKS LESFRDKLRE MHVRCWILHY TLVREAIAQN
     PELFETPLED RILYLRSVHN ALGIRKMCKR SHKQFLKLVK SEIFSLDEKA DYEYDICQLL
     YDIHGIKLSP VDGYLEDHGC PPEKLDRSTA ILMIDFVMKQ AKKMNIRDLS KSDLKYTIEK
     MQQAIGTTKS SPPLSYNKRI LTAYLKSPLN PTEIFRAVRG VEDLALLPVP TESAVIAKNG
     WYFLLGHAAL TKFRSQKRLN PVPTTDLDEA ITWFRQDLEH NTQRWESWYR LAQTYDSKLE
     EDITWSADKI NNNRTELVTW QRYAIHSYAM AVATAARNAD PTPETRALVS DLYTDFGIRL
     YSSSREPLSM AAFSLSDFTR HYNSEENQQM YEALPFKEMR LYSVWNLASY LLKRAIPDKP
     KSWMTRYMLS KCLWKMFSCD DSVRGTSKHV HLDDLLDSLL DSIDALPQKR DSRSDPIFEP
     HYKLVSIVHK LVHRGVVTPA EGSKTLVATP WARKVPPPEE GAPWKPYIMS VIRNLKHADK
     SNWHHRMAVR AAHITYDDEK DAAAAAGAKG ELTQQIFTKT MTIQVWRPEN ERPGRHFVYT
     TRYVYFFVAL LEQLEDRASL DQLLRRVRKK QGDFINHAKL WEDLCLTYAR VIRKAGNINE
     GHDESVFKPI GWDEFVANTA RLEGLLQLAP ESITLLELLR DAVELKKLNN NLMKVSLLED
     LIADIYSRLY EVNMPNVIEQ ANEENKEKMK VDHLLMASDG AADTPTPPTS APASEAPAPR
     GRTKGIARRD IQKRAETIVQ RKLAPRAPIA KAPAAAESEP SHGVGAVTSA PEQTKDTATS
     AAVADELASG QQSDIPNSLH DSADDESELS EIDDEKLSKL AAERSLLFPN LQDRGSLDPE
     VGMSAAASAD GDGANEGAGD GEEDADREED ADLGDEGETM VEEGETMVEE GDDGADGDEA
     EIDGEGEGEG EGEGEGEDEE DNEAAGEEEG VGEGDGEPEG EADANEANEM DVDDGGEQPA
     AAEADQESDH VSDSEAMDI