ID   HIR3_CANAL              Reviewed;        1591 AA.
AC   Q5ADX2; A0A1D8PKU8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=HIR3; OrderedLocusNames=CAALFM_C307680WA;
GN   ORFNames=CaO19.14011, CaO19.6719;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017625; AOW28767.1; -; Genomic_DNA.
DR   RefSeq; XP_019330892.1; XM_019475347.1.
DR   AlphaFoldDB; Q5ADX2; -.
DR   STRING; 237561.Q5ADX2; -.
DR   PRIDE; Q5ADX2; -.
DR   GeneID; 3638459; -.
DR   KEGG; cal:CAALFM_C307680WA; -.
DR   CGD; CAL0000198181; orf19.14011.
DR   VEuPathDB; FungiDB:C3_07680W_A; -.
DR   eggNOG; ENOG502QQX4; Eukaryota.
DR   HOGENOM; CLU_001316_0_0_1; -.
DR   InParanoid; Q5ADX2; -.
DR   OMA; WETWYRL; -.
DR   OrthoDB; 72175at2759; -.
DR   PRO; PR:Q5ADX2; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   PANTHER; PTHR15502; PTHR15502; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1591
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256196"
FT   REGION          316..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1569..1591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1591 AA;  182911 MW;  378BC914C8A3093B CRC64;
     MSSFIPLNFL EDTVSKKDLE EEHTRELQVE QAYKLFQSAL KLQKQKQYES AYKVYEELFK
     LDIVSNHYFE ELDFIRGLQD GSQNTDTDEL TLLSPNVKSL RYLIFRNRGF LYLDMLKSNT
     ENKSAEKVKE MFYPLLDDFC IALLYNEPDE KLLETLHEIF SYIGSERLSR FVLEYSLTSR
     KESDDLSGLL PIDQTVLSQY KTMLEHLSSG KFPKLDLKHL SFLEPIRLDI FAQQEKLASK
     KVAVIKSTST KWVDLLDAIN IHLKENQDES KIEDANRPRI RIFEPYVLTE EPLDIVRIEF
     TKRGVAVPAT ETEVTKAQPE QIVQERKPEE DNRVQRSSKR LSKVEDEIPA VTLESSHFLN
     MDYFRNQMNE TIPNFEIFDV CSTYVEDGSG AQYIKDFKNI VSDWNDSYAR AILSYDTAKS
     EDDNLKLLDL LSGYGKSEEL KEKNIPPLGE IDIEFPELNY VEFKTYIIKH LLSKILTTKW
     SDKLYEKFTE WIVQFEGYII NDIDVESAIG VLEVLVDIST SLESQIKDSI NNKLNKAVVN
     SMCQDLLRIK DKIIRWINYI ETFPINDLQV ASRFKWCQII KEKAETKSWT ENHPVKHKLQ
     KLLGDAHFKI NYPNYKNFID FSKDSINSQL TIISVLAIFW RILSTSSTED NKEAIRLLED
     ILLDSNTEPS DAILSIRNFL KQGSIDMKLS LWNILLSFYQ SSNSGDKLTV GFEECVLFLN
     DYLVNEYVLL DEESRLVTLS RILGFYGSSI SFVVTSLAST NWILMHPIKV QTLRLFFELS
     LLFEINEEAS YISSLATSIK SKSTKSYHHL TNTLIKTIIL ILASIQKSNP QILHSVIRLF
     HTQLGLIGIC GHAGGSFLEI AQEYLKSLPN SDQDICQIIK CKYHYSISID GVVPADHGTA
     RLDELNKNDC KELASFVLPL CFSKGGSTLN NVPKHDIKLL IDEIYDVIGD PDFDSNEALG
     RNKATLNYFL DNTRLTKRLF QEAFHGLVRL ELGEAEEDKQ FNGLYYIEGL LLFSSYKLRK
     KNMQSRAVEL ESAISLFEND IICGSNRFES WFLLGQSYGY LVEDDLIWTA DKLTASDRKI
     TTANLQRKSL ICYLMAINKS LDESIKDVIK PVVGNLMSLF AKEMFSAVCE PMSMHAFKVQ
     SHPRFINRVN GALFEPVSQF PAVDKTVCLK IIQQSLQLSI KSSCREWSDY YYLAKVQRKL
     DKPAGLVMET MASACRSAFK NKHADNIIEP HYNLVSFALK YVKSNRLDSK DALKYLIEDP
     LIKLEVGEET DFIKLIIKAL NKIDSSDKKN WQHKAKYRLA RLMQEEYHDV KGAIDQMSSF
     ISLKTPNKAL VSIWKPEPER PGKHFLYTFQ YIHFYIELLK EIDDLDSLVA MLPKLRRSNS
     VMINLSIAWE ILCSSVCKII RESYGIGDNF EFTENLINTL PYQTFAANVK LLPDMMRRQS
     VPENLKSVLC FLFTVNDIKK LNNGYGPTSF IDDTLVTLYF MIYLNYFEKS STEVTTDSPG
     LKKKIAKRDI FPLTNDILKA FKKDIEDVTK QKSYNELITA QKLKQGLNED KSLENVPASA
     NVNEIIVIDD DDDDNLSQEP ATKKSKTESN S