ID   HIR3_CANGA              Reviewed;        1615 AA.
AC   Q6FK87;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=HIR3; OrderedLocusNames=CAGL0M00286g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62333.1; -; Genomic_DNA.
DR   RefSeq; XP_449357.1; XM_449357.1.
DR   AlphaFoldDB; Q6FK87; -.
DR   SMR; Q6FK87; -.
DR   STRING; 5478.XP_449357.1; -.
DR   PRIDE; Q6FK87; -.
DR   EnsemblFungi; CAG62333; CAG62333; CAGL0M00286g.
DR   GeneID; 2891145; -.
DR   KEGG; cgr:CAGL0M00286g; -.
DR   CGD; CAL0136481; HIR3.
DR   VEuPathDB; FungiDB:CAGL0M00286g; -.
DR   eggNOG; ENOG502QQX4; Eukaryota.
DR   HOGENOM; CLU_001316_0_0_1; -.
DR   InParanoid; Q6FK87; -.
DR   OMA; WETWYRL; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR   GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   PANTHER; PTHR15502; PTHR15502; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1615
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256197"
FT   REGION          339..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..361
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1615 AA;  188141 MW;  FBD58D912B9C978E CRC64;
     MSSFSFLNQS PDIEQLEAEE HTRETQIELC FQLFQDALER LKDDKFGDAN DLFEKLMSQE
     VIKPDKWGLY AYSSSIVDNL RYLAYRNRGF FYYKFLMNQY SESMSSEDVV DNILKIVENL
     LESLRHSEAD YNVIEVLVQI FESFKSKRLQ KLLLENEFMN NDSHLLFSGR KRTNILPQLK
     VLISQYINLL KDLHASSVLE KKIICNGQAK NTSHLPRTNV KFKNILEQLN KLRTEDDELI
     KSLDIHDIEL DNYDWTSLLR SLRETLPTVK SLALFGRNSD PYAETETPIE AVKVIVKEEV
     VIDKIHDNSN NENEVTEEKE ITDNKVVTTN GNNRKRSITE IETKHAQRSS KRFRDRDSSA
     ADSETPMTFE PMFYSYTKIL SLLGCKAPYD YEAIYPDLME VKANDIIYAD FLACLKEWSH
     WHTDCLSSQN EKEIKTKKVE SSTDVSLSHF KTLLNSKNFQ KSDDHIPEIS QTSLRRFLDK
     VNRQQCHFHE LRFKLIWFLF DNQNGDRLLT STRWTKQMYR DVEWITLSIE KNIFSFIQSD
     IAKYRHVALS IFETLINSLV ELCEEINSKL SLGQKANDQK TQKVKIEKKI TKWNSIIAQV
     ETTDRDWTVR YLWAYYTLIQ CTSDIQNCLL SNILEKVHQI LMKDNSSTVY LYPNADFISS
     FDLSFVDTQL KKLKMIKKLV NVDKHSESDK SEDNNSQFIM LENVLLSTIS ENHAVGGDDD
     DMIDFFMSAP FMLKFKLWEL IYMKYVKKND IEKTTLIYGI MLKLLVDTLE CKTYRTLGPK
     KRQERLLIMM SCLKDITHNC IEVLKNNAWL QKKLSWYDDT TSQLVFIFFI LFPMLPVNTP
     NKLSGTQTFF QKATKSSKTI KSIFVDILTL LLFHLNIGLK SKISSEPELE NSIIDLVSTT
     HISISFYNFC DYASGNFLQI AENLICQFTN EEAFTQLKQI MWCKYHYQLS GDSSIVSQHK
     TKAMEMSKMV SLPLGIYLVK LQYQDKHPYI NSAKIASKQI LDNIVETFGD LSSQDNYIIM
     RNLHAFNGYL RSNITSKLFQ SCFEGKDKVD LKNPNDEFQK AMDAGVFYVS GIQALNLYKI
     RKRSVQARPS ELDAIITMFK NDILYNTKRF ESWYLLGKCY SYIVEDDLLW TADKISSSEK
     KAVIATTQKR AILCYAMSLT LFFENETTRT VDEQIVIVEC LESLANELMI AVYKPMEALC
     FDTNLSSLVV SSSNPATSSE IEKSSVAPIY SITDSSIEDT MIKCLTLANR YQESLLEAGK
     LDRLNWFNFY SIAIVYSTEK LDRKGDMIDN MSKACELANK YTSVKDSVVE PHVALIHMLY
     KLYIEGKVTM EDTLSTLKRD KFFEGFDDDF WILDVSLTQD YQKREFFSKL IELLKYVISK
     DKKKWQHEPY FYIAEILFME MKDVEKSREW MDNIISIRSV NKNLVNIWKP DYERPGKHFV
     FTHNYVMFYL ELLKYDKDAQ SIGLLTKKLR RFSSGMAYIG KANDVATSYF IECVTKKYLL
     HDKVYTESYM GNINYNDFVK YSQEIVDNSK AADIAEDILE VLKIAYQLKK GTNSVVYDTV
     CLSLFFQYIY EPYRKEHPET EPQLVSDSEN KSNIRKKVSK KDAFDKIRAL VDKLP