HIR3_DEBHA
ID HIR3_DEBHA Reviewed; 1776 AA.
AC Q6BMI2; B5RUA1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Histone transcription regulator 3 homolog;
GN Name=HIR3; OrderedLocusNames=DEHA2F05258g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC for the integrity of heterochromatin and proper chromosome segregation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR EMBL; CR382138; CAR66279.1; -; Genomic_DNA.
DR RefSeq; XP_002770749.1; XM_002770703.1.
DR AlphaFoldDB; Q6BMI2; -.
DR SMR; Q6BMI2; -.
DR STRING; 4959.XP_002770749.1; -.
DR EnsemblFungi; CAR66279; CAR66279; DEHA2F05258g.
DR GeneID; 8998886; -.
DR KEGG; dha:DEHA2F05258g; -.
DR VEuPathDB; FungiDB:DEHA2F05258g; -.
DR eggNOG; ENOG502QQX4; Eukaryota.
DR HOGENOM; CLU_001316_0_0_1; -.
DR InParanoid; Q6BMI2; -.
DR OMA; WETWYRL; -.
DR OrthoDB; 72175at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:InterPro.
DR InterPro; IPR033053; Hir3/CABIN1.
DR PANTHER; PTHR15502; PTHR15502; 1.
PE 3: Inferred from homology;
KW Chromosome partition; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1776
FT /note="Histone transcription regulator 3 homolog"
FT /id="PRO_0000256199"
FT REGION 180..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1709..1776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1732..1776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1776 AA; 205042 MW; 383B5DC05C092688 CRC64;
MIDDMIISLI YQEADEKLLN TLYEIFTYLN SAKLARFTLE YLISGKDESD DLFGLIPVED
LCKQKYKLLL QRLHISKPSS SDGDGTRELE LIKEKLAFLE PIKADYNTSI ENTTNLKTVN
INIEYAQRDL NWTSVIDDIN KKVKHLQDKE KSQELSRLRI KDLDPYLLTE NPIERVRFTI
PVPEDESTHD DDVEKNDSKE VDKENNEVPD GEILIDEGSN HINSDEEIFL EAREFLEKEI
NDGKETQDSK NPSEKDVEGS TCKLDHIPAN REVIEGEKHI SEENAISKSA PMIQRSSKRV
RYRNEESSME INDVEITRSC FVETERFFEN LNSYLDLFNK EAATNLTLTN IVNIYVPEKN
NNDENSAEGY VNDFLFILND WNTRKYTHSL FVDDDTPAGS TASKSTEDEK IKLMEVLSTF
GKKGDSLNSD LSKDIKDISS YETTEEIQKF LHDINENPCH YEELKLLILR KLLSIQRPKG
DFKGHAAYCL ITDTIWNSKL YDRIREWTIQ CESIILNHLR LEGCDALGIS HMLDDFSFSV
AIYEILVDTY ISIKDQINSM TSLNYKRTTH KPNKATLNNI SLELVKIGDK LNRWTQHFED
LLERIDLSFA MMDQDFFTYY CRYKWSFIHK EKSQNTIWQE KGFIMSQLHE LHDNISTKKE
AEAHIPLPNY ENINEISVDS IKTQVTTTSI LSILAKILYA KPGTNNDEAI HLLETILISD
SSPDESIEAL PLNKEVSTFD KDALIAIKDF LEESPVDMKL SSWNILFSYY DENNQFAKFQ
HGFEQNVSFI LYYLNSNTYN GLIGTKFETL AKVLGSYGKH VRIFLSHLRE NNWKLSRDSH
RTSSSIERTF SELLKLFELF YLFSIHEEAA LISSSKLSVK ARSNKAYERF KDIFISTVSV
IVIYYKELLM NTVKIEESKV PSEIEKTIGN LICDFHEQLG WRRVCDAAEG LFLNLAQDIL
VAFDNNLFEK QLAQLISCRY HYSVSIDTFT PANHETKKTA EFDLSSTQRM ADFILPLCFK
KNPLKATPKS DMKLLIDEFY EVVGDPDFDS CEILSRNDSL FEHFLESTSI TSRFLRDTFY
GLEELDFRNP PDNANIIRSG LYYMQGLLMF ASYKIRKKST QSRAVELENI IMLLKNDLVY
CTNRMESWFL LGQAYGFLVE DDLIWTSDKL TVPERKIGTA NLQRKSLICY LMAINESTKA
NIKKDLPLKT TIGSLMALFS KEMYNAAMKP MDMHAFKVQN IPRFIKKPTG AAFVSVSTSS
VNSNLCLKVI QQSLHIAIKS KRNDWTYYYY LSKVQRKLNK SPRIVLDTLQ QASNIAKEQS
NPSDPIIEPH YKKCSLIYKY AKEGSLSFQS GLEFLKNDMV INYEKGNKSI EKPMDFYEII
VECLKAVISY DKKRWHHKPR YRLAKVLFEE FGKITEAKEE ISSIVSLKST NKTLVSIWKP
ENERPGKHFY YTFQYAHFYV VLLSSDRNLI GLIQMLPKLR RSNSIMVSLY SLWETLCSSI
CKIIRNSLKV DEGFTERFMS SSGYQKFMMN SKSLLENMKG DGVPGELQIH LCFLHAITDM
KKLNNGFGPT SLIDDTMVAI FIRIYLYFEK QSNNLKPMGT PEPTESPNEK AKKLAKRDFF
PLISDMLKTF RRDIENILKD QPDIYNDFVS CSDKKVEKEG VVGKENNVNS KILEEEQSRE
VIKTPELKMD SINFESVSDK HITQNKLEAD TILQENNDKS PKNNGIKDNE NSIPDSRART
LDEMLFNKGL EKKVQGESPT AKKQKLNSDH HDSASE
