HIR3_EMENI
ID HIR3_EMENI Reviewed; 2061 AA.
AC Q5B8K7; C8VIJ7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Histone transcription regulator 3 homolog;
GN Name=hir3; ORFNames=AN3123;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC for the integrity of heterochromatin and proper chromosome segregation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR EMBL; AACD01000051; EAA63694.1; -; Genomic_DNA.
DR EMBL; BN001306; CBF83365.1; -; Genomic_DNA.
DR RefSeq; XP_660727.1; XM_655635.1.
DR AlphaFoldDB; Q5B8K7; -.
DR SMR; Q5B8K7; -.
DR STRING; 162425.CADANIAP00009953; -.
DR EnsemblFungi; CBF83365; CBF83365; ANIA_03123.
DR EnsemblFungi; EAA63694; EAA63694; AN3123.2.
DR GeneID; 2874143; -.
DR KEGG; ani:AN3123.2; -.
DR VEuPathDB; FungiDB:AN3123; -.
DR eggNOG; ENOG502QQX4; Eukaryota.
DR HOGENOM; CLU_001419_0_0_1; -.
DR InParanoid; Q5B8K7; -.
DR OMA; WETWYRL; -.
DR OrthoDB; 72175at2759; -.
DR Proteomes; UP000000560; Chromosome VI.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR InterPro; IPR033053; Hir3/CABIN1.
DR PANTHER; PTHR15502; PTHR15502; 1.
PE 3: Inferred from homology;
KW Chromosome partition; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..2061
FT /note="Histone transcription regulator 3 homolog"
FT /id="PRO_0000256200"
FT REGION 339..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..2061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1977
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2009
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2061 AA; 232556 MW; EEDB76BE8C7C10FA CRC64;
MSTWVALNIE PDEAIEEEVD DTKEIQIEEA LKLYQNALKL HSQGPRYYKQ AGEAYEALLD
SEIFKYPESL SDHKRAALQD AEPQVGGTTN DAVVGEAALD FNINDTTSST LQQTIYLSYK
NHGQYVLDAL RASLQELSKL SEDSSHLSSK IAESSTTALA QFAEALERDD TDLNLWRQSA
RLCSALQSYR LTRFCLESVL ADDDNRLEVR SEQLGLEETF AEEGLRKTLH SVQDRLSVSL
VPIKKPKKAL LKFFKQQSDP YPYLPSLPDN LQDLDSSRNP LAFRASTHEI KIDSLTWAAI
GQAILTFLDD KNGTPSLAPG TSITISLPAD SPELKTASIT AQRRPSKAQV DENNNQDVQM
DDAQSVGARS VTGAQGRELA MEHGDDQSSV DQRAEKQLIE SLEVQSIQHQ QSTDPQEDIK
AEEDDLKYPE NTSRKRSSGS AITEDQAERL RVKSRRTRLR DSLAEASTHT DDVVFDQAKY
YEDLLEPYIQ TDEGVFGTVG ALLSKLGVED LGTFEELRRS VASAGERKDS PVTPVNIDNA
EVLLQDLRNV LTQWDERLYQ VMQQSDSLAG LQDIKSMGRS GLAVFLEHSK KTTHKLKLKQ
TFSGEDELFD FIRAVNGSRL HLHDVVFEWL GCLLRPDYKN FLTHDNQFND WSLVESSYVA
YQWPTTLKDV VLQLLSLEDE YIHGKLEEGM QTLEHHILEA QSGTPFRYTA KHFADLEMIQ
AIYELHLDLY APMNAPNNET DHRTRTLQQD RLARWSMLAR SALTHFIDCC PERVNRERIT
IRHIWASTFH SNMGVDAQRE HILLCLEDLK RLFSCLNEPV LSLANSSIMS ELSCEAIDQE
ISKLNSMDFF TRIFNPDSED PVGLIETIEP IVEPSAVQFE EGSEDRQSLQ RREMGSFLDR
GDATLRLFLW RRLQDAYRKI DYPPKVVSCH LRSIETIIKE LRSQAYVEEP GEHRQATLVR
WLKSLDGMLS KTVTTVLQES DKAYDCFDTE HVKSSMSAVA FLIRLLHSFV LYDDSVRVGQ
SPGIDLRAAL AKSLENFKEK MRDMLVRCWV LLYTLLKEAI AQNQEMFDEP LEDRVYYLRA
VHNSLGLRQM CKRSRNQFLK LVKSELLALD VEQDIEADIC QILFDIHGVK LSLSDHLLSD
HGCVPEKLDR STAIMMIDFV MKQAKKINIK DLSKSELKNT IEKMQQSIGT TKAVPPVSYN
RRILNAYLKT PINPSELVRA IQGVTDLPFI PVPSQTAVIA NSGWYFLLGY AALTKFRSQK
RLNPVPTTDL DEAISWFRQD LEHNTSRWES WYRLAQVWDS KVEEDITWSA DKINNNRTEL
VTWQRNAIHC YAMAVATAAK TAESGPETGA LLADLYTDFG IRLYSSSREP LSMAAFSVAD
FTRHFSNEES QQMYEGRPFK EMKVYNVWRL AAFLLRQALV DKPKNWMTHY MLSKCLWKMF
SCDDSVRGSS KRISLDSVLD SLLDTIDALP QRKDSRSEPI FEPHYKLVSI IHKLVIKEVL
TPAEASKTLV ATPWARKVPA CEDRNSWKKY ILDVLKNLKN ADKANWHHRM AVRSARIIYD
DNKGAIAAAE AKSELTQQIF TKTMTIQVWK PEYERPGRHF VYTTRYAYFF VTLLDQLDDR
ANLEQLLRRV RKKQGDFINH TKLWEDMCLT YARVIRRAAG ISEGHEESVF KPIGWEEFSS
NTARLEELPQ LAPESPSLLE LLRDAIELKK LNNNLMKVAL LEDLIADVYS RIYEVNLPIL
LEQVDEENKE KMKVDHILMT ADGAATADTS TPPTSAPASE APAPRGRTKG IARRDIQKRA
EAIVSRKVPP RAPATKAPTT TETESATNAT NSVGPKPVVE ISVRQPPAAV VDSAGQQSDI
PNSLHDSADD ESELSEIDED KLSKLAADPK MLFPNFGHRS RGSLEPDSEL SAQASPSGDA
DVANENEEVG ELEGDDREGE DEGEAGPDAD LEEESMNDGD GDGDGDEAGE GEGENENENG
NDGNVSGNDE DDDVDMEAGE EEEEAPGQDG EIEGNTTMEG TDAADGEDPE HVHRQEQEQE
QQVGGEQEGE TVYDTELATE L
