HIR3_GIBZE
ID HIR3_GIBZE Reviewed; 2020 AA.
AC Q4IFH8; A0A098DJ41; A0A0E0S624; A0A1C3YN08; V6RB63;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Histone transcription regulator 3 homolog;
GN Name=HIR3; ORFNames=FGRAMPH1_01T14293, FGRRES_04030_M, FGSG_04030;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC for the integrity of heterochromatin and proper chromosome segregation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR EMBL; DS231664; ESU09125.1; -; Genomic_DNA.
DR EMBL; HG970333; SCB65888.1; -; Genomic_DNA.
DR RefSeq; XP_011321624.1; XM_011323322.1.
DR AlphaFoldDB; Q4IFH8; -.
DR STRING; 5518.FGSG_04030P0; -.
DR PRIDE; Q4IFH8; -.
DR EnsemblFungi; ESU09125; ESU09125; FGSG_04030.
DR GeneID; 23551300; -.
DR KEGG; fgr:FGSG_04030; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G14293; -.
DR eggNOG; ENOG502QQX4; Eukaryota.
DR HOGENOM; CLU_001419_0_0_1; -.
DR InParanoid; Q4IFH8; -.
DR Proteomes; UP000070720; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:InterPro.
DR InterPro; IPR033053; Hir3/CABIN1.
DR PANTHER; PTHR15502; PTHR15502; 1.
PE 3: Inferred from homology;
KW Chromosome partition; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..2020
FT /note="Histone transcription regulator 3 homolog"
FT /id="PRO_0000256201"
FT REGION 264..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1838..1861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1862..1897
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1898..1912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1931
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1953..2001
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2020 AA; 226951 MW; DB1198CAB148C5E5 CRC64;
MPAFQAINLE PEDNIDEQID TTKEIHVDEA LKRFQHALKL HAQGPRSREA AEAAYNELFE
SEIFKYREAK TDYERAERYA DGQPEVSNLD PSLTDGGLDV DAGGADGVAA SLAQALYLSY
KNYGQFFVDK FKDASTSDTA WKEKAQLKYH DDGRKVLDSW MTALDQDPSD PELWRKAARF
AGAINSNRIK RYCLEAAIEL DDDPAVMELD PPSLAEGMAG EQLKDQLKLL GDDMALSHPI
MAPWLKKKMP ALLKRHLDPI PFLPDPTKSL IPPKVSDTQA QTQEDTEMGD ADNASLTEPK
SVSSWAELGA KLINCLETTA EAFDTCDGIV ESSLEDVPIE TPPNEIESVA SEIEVAVTKP
TETEKSPEKD STPKEQKAGS EGTEDSQKTA DQSQKDSNGA SARKRSQSAA GLPDGAEEEN
AMEKRSKRVR RRETLQAEET TDPNTLIANQ LQPYQGADQN LFQMTKSVLE HLGVEDKSTF
AFITELIDSC ATENRPGKIT NLAACDLSSV IVNFREEVAK VFLHKNEQAS LGPSSFLEHA
KTGSQDQPSM PSFNEKQGLR SFARKIGGCR SWMTAEDVAY EWVRAVSQSY ATAKWSDKMK
LSVVQMLNKV DSTLYRKITE EMELAAGSAE RLADLETIVP MLFELHVDIY ELITNPSSVV
DYATRMDTKY RLGRWLDIAS AYLRLIDRPA NDPLIARFLW ASVLVSSHAE QPLREHILLM
WTSLRDHLAD EKVPAISLPN NVVMPTISPA AADREISKLT TMDFFLGLFQ DNMDDPVFVI
DTLEPVLNPS TVCAPNQGTD SESGEDSDSS ASSDTTGAST LDSSDDSTDD NDESSDASSN
QKQKKSISDC ASQSLKDLWK FLHNSSTELR LFLWSRLGDA YDAINYSTKK FSCCLKSIEL
IVSDLEGETY ANTVPESRRL LFMRTLKSLD ELLITALGSA LNDNTAFEII DDAHIRSTSA
ALAKVNCLLH VASLCEDEVR IGIKPERTGN AASKAAFQAL KNKLKEMQIR AWCLQYTMFK
AGINKDNCII GPENDLADYL AAIHQVIGIR KFCKASNKIF LKVMRVELLK LKNIENWEDY
LGQVLYDLHG LKLGAGVWEV QDHACPPEKL EKRQTMQLVE RVCILANRMP MKDLLKSDLK
TTIDHMQQTI GQTKSTPQMY HNLRNFTEYL KKPIHPLRLY RALIGDVSVD AVSVNTPETI
LATHGWFFLL GMMALTKFKG VELNRRQTPG ATDDLRIGAT FLRLQLQFTA DRWDAWFRLA
ECFDYELDEA VLWTADKMNK ERPELVKFQR NAIHCYTLAL SHSRNLDIET HDGDPLHDLY
HKFAMRMYAS SREPFAMEPF QHSDQERYFI EDMGIGTFKR ILHSQMNKYK VWKFAAKLFR
MAMDRKPDNW KNPYMLSKCY WKMYQTPDDQ LDVKDITSKI GLMTLIDTLK KAVEVAHNAR
RGRNTDPIFE PHYKIVTILH KLVIRGDVPA KDAAEILSEQ PFGLEVNPDD HFASFSALED
WEEYIIRNLS KLKEKDKANW QHRIIIRHAK ILFDEATEVS SEDRLVNAKA AFGVLRDSMF
TKTMVMNVWK CDAERPGRHH VYTEQYVRLM TKLLVIMNDR GNLEQLLRRL RKKGADFYHF
TDLWQSCCMA YLKLLRQGYN VSPVADDAFK ALSSEEFEVV GERIADWAAS DGAENPLFNC
MKEAIEFKKL NANLMKVAPI DDLLYDCYSR IYSEIAKTLP GPDPSKVVEE RHHAKEVAAQ
LEAAQTETKV TSSLASILNA PNGQESITGT ATPMETEKQE AAPRSRKTGV RRPDVLRKAE
QAVIRALEAP KPNKSRVGSV SSGKRGSRTP NQRASDAGSE EDGPDSQIRR EAGHDGDVDM
KDAGDENEED HGEEEHDEEN EDEQDEEHDE AAEDENAEEH GVEEKADSET GSIEDSADDE
SDLSDVPEDY DEEVPPGLRF SNLGHQSEES SGEDADSESE GDDEAEESDG EEEAEEEAEG
EETLGIEDTE LADEDEDEDE EQPKRSGSWA ANDSIRAVGW
