ID   HIR3_KLULA              Reviewed;        1651 AA.
AC   Q6CWI4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=HIR3; OrderedLocusNames=KLLA0B03850g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02098.1; -; Genomic_DNA.
DR   RefSeq; XP_451705.1; XM_451705.1.
DR   AlphaFoldDB; Q6CWI4; -.
DR   SMR; Q6CWI4; -.
DR   STRING; 28985.XP_451705.1; -.
DR   EnsemblFungi; CAH02098; CAH02098; KLLA0_B03850g.
DR   GeneID; 2897527; -.
DR   KEGG; kla:KLLA0_B03850g; -.
DR   eggNOG; ENOG502QQX4; Eukaryota.
DR   HOGENOM; CLU_001316_0_0_1; -.
DR   InParanoid; Q6CWI4; -.
DR   OMA; WETWYRL; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR   GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   PANTHER; PTHR15502; PTHR15502; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Repeat; TPR repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1651
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256202"
FT   REPEAT          30..63
FT                   /note="TPR"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1575..1632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1584..1628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1651 AA;  191460 MW;  1D662C22EBF5D104 CRC64;
     MSSFAALNLS TNENADESKD HSRELQVEES SKIFQLALIQ LKAKRFDDAK ETFDRLFEID
     VIKPNKWGLY EYSSPTLDSL RYLAYRNRGI LHYQYAKENF KQMESDDVVE HILKTLECLL
     ESLQHGEADN TVTHLLLKIF WSFNSTKLSR TILEYELTRS PEEIRLLSSL SAMFKDQKRV
     FKQYSQLLKK LHVTSLPQNI PTAVEAVLNC IETCDVEEGQ IEPLLKDIKA MKTEDDEILK
     ELDGSNLNLN ELSWEELGVS LRSLVPKTKV VNILGRKSDT YSDLEAPIEY VSFTTDEFME
     KLSDSSNESP GHSPEHFEDA VSVMPETNNI EVSVEREPSA KRQDSTDRPA QRSSKRFKER
     EKVQEPDVEQ QVEFHTYIIN EINQSLHVSG IEKDISIEEL DPNNVAKRQE LCMSDFYDCL
     TSWTNKHTEF LKQGQENFSV KGSTDDFTQL TMLLRSSMFS GDVEPTDSLS EIEAEDVRRF
     IRDVNDKKLH FHAVRFLFIK ELLKLREDGT CLVTDYFWSP ALYEVVEFFS MAIEVNLYQM
     IEPSTDESTV SIAVSIFEIM TNMMGNICND LANKKAQGQK YNELESQRNK LQRKIVRWYE
     MLLSKPLSTK LKFRFQWSHF SCLQCTTDVT NSTLITTIED IENSLKEFPD FGTVAYSNYN
     NISSLSLKTV QSQFSKIKML RRFTIVDIEN EDEDNTHKDY IEHLYCILNQ IPCEGTDFQS
     LLSFVNTSPF LMKLKLWKLL LNYFASRKDQ LRFQNCFFSS IKFLLARLSS EEYQIQSQLQ
     RQQTLLSTLT HIGEFSKRFF QVLCDNWDMS LKNPSRDQLQ VLVSIFRLLY PLVFYETLTE
     KNASLKSFFK KAVKSSITIQ DIFLTVASLM ILCHKFITLE KENAKEEFTG SIIDLISALH
     MLAGKFEFCD RFDGNFLKVQ EKLLCEFSND SAFTHLKREL WCRYHISIGL DNPEDQHQTH
     AQPMVKANAI MLSNYFIKFQ YQDRNILVLS NNRSNFKQFF ETVMELIGDI DYEANHVLSR
     NEYFFNQYFT APITLKTIRD AYAGEFEIEF TSPNDDLQSG VDGGLFYVSA VHALNQYKAR
     KKSMQARPSE LDAIISTLTT DILYNTKRFE SWYLLGKCYS FVVEDDLTWT SDKLASRDKK
     QATAFAEKKA ILCYLMALSL YLSTFKETTS EQMKNDNKIV FRNLLESLGK EMLQAYVKPM
     SSMSYTWKLK PVLVLKADGS LENLPISYKP SISETNILRC ILMILAKADT LYNKDEERNW
     MNPFYISKVH FKTDRKLFKE SGICLLQDSC RLALLQSSVS GSDNILEAHY ALVSYCYKCF
     KDRTFSLAEA ISHLREDNGF FGLPEEEWQV EDDKSFFNLI IRLLKYILSK DKQKWQHRPI
     YRIAQIKYTE FEDTDGAMKE MNKLLALKSV NKNVVNIWKP ENELPGKHFV YAYQYVLFYM
     DLLNEKHDFM AIGGMVKKLR RFGSGMINSQ DAINKAVELF VNGAKVKLSL NEKEHGELLM
     QRIPFPEFVE LSEELFNAFK KGDYQSDVLD VFLLAYNLKK GTNSIQFDGV CITIYFKYFY
     CPFVENKKQS TPYPAPIIEG ISGPQPENSP SQQLPQSQSQ PQLPRSPSPN TANNKEKTAK
     TPVKNPTSIR KRVSKRDVFD RVVKLIEKRL S