HIR3_SCHPO
ID HIR3_SCHPO Reviewed; 1630 AA.
AC P87315;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Histone transcription regulator 3 homolog;
GN Name=hip3; Synonyms=hir3; ORFNames=SPBC31F10.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND INTERACTION WITH HIP1 AND SLM9.
RX PubMed=16428807; DOI=10.1074/jbc.m512170200;
RA Greenall A., Williams E.S., Martin K.A., Palmer J.M., Gray J., Liu C.,
RA Whitehall S.K.;
RT "Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for
RT transcriptional silencing and accurate chromosome segregation.";
RL J. Biol. Chem. 281:8732-8739(2006).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC for the integrity of heterochromatin and proper chromosome segregation.
CC Required for transcriptional silencing in the outer repeat (otr) region
CC of centromeric repeats and the Tf2 long terminal repeat
CC retrotransposons. {ECO:0000269|PubMed:16428807}.
CC -!- SUBUNIT: Interacts with hip1 and slm9. {ECO:0000269|PubMed:16428807}.
CC -!- INTERACTION:
CC P87315; P87314: hip1; NbExp=2; IntAct=EBI-1556159, EBI-1556094;
CC P87315; O74309: slm9; NbExp=3; IntAct=EBI-1556159, EBI-1556117;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAB10090.1; -; Genomic_DNA.
DR PIR; T40217; T40217.
DR RefSeq; NP_596576.1; NM_001022497.2.
DR AlphaFoldDB; P87315; -.
DR BioGRID; 276759; 10.
DR IntAct; P87315; 2.
DR STRING; 4896.SPBC31F10.14c.1; -.
DR iPTMnet; P87315; -.
DR MaxQB; P87315; -.
DR PaxDb; P87315; -.
DR PRIDE; P87315; -.
DR EnsemblFungi; SPBC31F10.14c.1; SPBC31F10.14c.1:pep; SPBC31F10.14c.
DR GeneID; 2540227; -.
DR KEGG; spo:SPBC31F10.14c; -.
DR PomBase; SPBC31F10.14c; hip3.
DR VEuPathDB; FungiDB:SPBC31F10.14c; -.
DR eggNOG; ENOG502QQX4; Eukaryota.
DR HOGENOM; CLU_001419_0_0_1; -.
DR InParanoid; P87315; -.
DR OMA; WETWYRL; -.
DR PhylomeDB; P87315; -.
DR PRO; PR:P87315; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000417; C:HIR complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006338; P:chromatin remodeling; NAS:PomBase.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15502; PTHR15502; 1.
DR SMART; SM00028; TPR; 1.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW Chromosome partition; Nucleus; Reference proteome; Repeat; TPR repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..1630
FT /note="Histone transcription regulator 3 homolog"
FT /id="PRO_0000256203"
FT REPEAT 8..42
FT /note="TPR 1"
FT REPEAT 1230..1263
FT /note="TPR 2"
FT REGION 325..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1630 AA; 186701 MW; C641C83B1025E668 CRC64;
MATFTPLNAA SEDLDKEKRT LEIRIEEAVQ IYQNALSAQK QGDDNAATKY YDELLNVRIL
RELPFTVNSN YKKNNALLLL HYLTRKNHGL FLLSKLQSLL SLDPSTDPIP VYRDALLDFA
IALACDYNDI ELWSFVAELA EKLEMPRIQR FALESSFYTG YEPFDAERVF TNIDDLNPGK
LISLQNLYNL LKKLGGIAEP LPQLDLSISS LYTLPSFFPQ LPTPSFHRRS INLCPKIKKL
QLSHDTLHGF LDLVLYALQI NEKKTPTRGF PSTLIIHVHS LNLSTAESHD LESTDSELWS
EISDAGPDTN TINTAAKLSE PVYAKDIVPP PSDNLPKPQL LKRPIDDSDV RISKRSRGRD
LRTPSESNLF SLIASITSDI NEQIQKRFPD ATSPFSGESM FREYSSIFED YHQLLVNFPS
EGSIPDLDVS TDSAANGAFS KMILIDLAMH SANRLEHMQV PDGYLLQLLS EVNSLNMVPA
ELATFFVESM LRPRKLEPPF YLQQCWGKIF KKKFTTICER IESTLHELVK ASLQTPEVFN
ISQSLFELFL DDYFLALKFS SNDQKDDNVS EIPTESLEYK KLRCLRWKSL TEQVVELQPS
CKSSSQRHLI IRNSWARNLL LRLTGCSSEA IVENFKQLRC LLQENSDSLE LLNSQCMADL
SVQVVDFELS KLQTVEFFNT LFMNTKNLDF NAVIKNLEPV LSPENKFAED PQAKFISQFL
EKTSTEFQIH LWYLLYQAYS SAHRPYNSLL CAFQSLKIIL IRLCSSSFSI QDAGRRQAEL
LGMLNFSSNL FRIIWQKLHE QPDILSPCNE MTVIDCIRII LIYLRTFAIY VGIDEDISDQ
RIPKPSNPEF DSYAQTVKDS LMSGWCIFYT LFAHLLHYDF IKADAQKLLP QILTAIHSQY
SFRGYCSSSN QSFLELSQTE CQRLDAWENE NEILQCVCCR FNLIIGSEYY VPQSHQSDSV
NLTSNDAIKI IPFILGFAVK RSHGWVMPRS DQKNALEIIC KVIRFPGENN ADVYFNKCAI
KEFLERDISP QLTKMLLKSN DILGLREIGS KVVDDRVRGL YYAQSQVLFG YYRSRLKGSR
CINDLLVIIK YFLLDLYLNP RRQDSWYTCS SVFSSLADEE LGWSAEQICL ADDVINEYRR
KAILCNLMAL SLPFTQDKLF KANVYFDFAM NLYASARPPL EMAAFLPSET RVFSGASGLY
NLSMKPIEVS KVIALAADYF GMSAELSNDW RALYMLGKAC RKCGDMENAL VHFEAAAALA
PTKSGSGSQQ ALLIEPHYAL LSNLSKAAIE GSVEIVQILS YLRRIRHPPK DSGSLLEVKN
EDVNIYKRNA LLFILKALAE MRILDKQSWH HRPTYRIAKI MEHLGNVQQA KEEMETLFSY
KTSGKSLLNI WRTPNERPGR HFYYGATYSR YLLSLFYKTN DKVNFLQFLK RFRRSSSTIY
EHRQIWLDIM IKYLEDLRLQ HSVKETQIND LPLVEFKYVY KEISLLDEQK LSLLHQVYEI
RKLNNGLYPT IKVDDFLIDC FMSLYNEVKS SISPLDANIP NSPSTITAKP LNDEKAINNE
NSVKQKTVIT RKDVVSKVLA LFRPHRETYY RETQNKILQK LASTSSSLVR SFTEDSSQAG
ESPGIHEEIQ
