ID   HIR3_YARLI              Reviewed;        1921 AA.
AC   Q6C9G0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Histone transcription regulator 3 homolog;
GN   Name=HIR3; OrderedLocusNames=YALI0D11506g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in a nucleosome assembly pathway that is required
CC       for the integrity of heterochromatin and proper chromosome segregation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HIR3 family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG80890.2; -; Genomic_DNA.
DR   RefSeq; XP_502702.2; XM_502702.2.
DR   AlphaFoldDB; Q6C9G0; -.
DR   SMR; Q6C9G0; -.
DR   STRING; 4952.CAG80890; -.
DR   PRIDE; Q6C9G0; -.
DR   EnsemblFungi; CAG80890; CAG80890; YALI0_D11506g.
DR   GeneID; 2910356; -.
DR   KEGG; yli:YALI0D11506g; -.
DR   VEuPathDB; FungiDB:YALI0_D11506g; -.
DR   HOGENOM; CLU_001419_0_0_1; -.
DR   InParanoid; Q6C9G0; -.
DR   OMA; WETWYRL; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   InterPro; IPR033053; Hir3/CABIN1.
DR   PANTHER; PTHR15502; PTHR15502; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1921
FT                   /note="Histone transcription regulator 3 homolog"
FT                   /id="PRO_0000256204"
FT   REGION          350..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1402..1466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1738..1769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1799..1921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1404..1421
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1801..1817
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1818..1839
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1840..1854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1857..1892
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1895..1912
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1921 AA;  215884 MW;  FEC85B47151D85CA CRC64;
     MSSFIPLNAL EDYSLSSAEE HTRELQIEEG LKIFQKALHA QRQGKLDEAF DLYDALFKID
     VIHLDIDDNN LSPTVGRLKY LAYKNHGILL LEHLAHNLDD LTTTEIRDQL QDILVQFADA
     LLVDDSDDSF LKLFSDLARI IGLKRLSRFA LECIVSSPSR VFTFSESLLN HDFLNPEEVA
     ILQEVVLLAK QLQDYVSMDS PMYDLMASQV ADVAPAKKPK YISWIEPTQF KAPPLKDLKE
     TWRGSELVVE IGVPSWRGIC KGLHDSLHRL TKRKKVLNGV TIRDPYLQIG VEISSVHGKL
     VDEEDLEDPE DDVEMMDIID KPAEETIEVK TEEALDSTVK VEEIPAEINI GEVENKSSTE
     ENKKQESPEN GDKKEASGNG NGSAGPPVKD TTVKTEDRDS LTVALAIKRP AEGTTSSSQP
     PSKRTRGRGA DEPAELEKQV DPGFFNNITS FVGSLDLKFP FVDLNQLDNE EQFYQDFKAV
     ISNWGEQGSE LFLKLSSAPE SNLSVPVTQI LDSAAQVDDD YGAPCNVLSI SPDKFLEQMS
     ESCSLSDFRF KIIEALLGNS SLVNEIWPSE LIASVQIILN HLEPQILRDV RQMFFDGQTH
     SDSLIKQQLY VAEARYELVA NEIIADKQRI TENTSKLTKS ALRDREWHKK TLHQRLLAWE
     SCVITLLSMC KTRQLSVTEL ELRHTWVRLS LSQCDEAEIS RMRQNYEEFQ VQLLDEAPDL
     MVRFVNFPHI QTLSLDSVNG QISKLKVAST FAKIFSPDAD EDIGTRIAML ESILKGSSDT
     SGDRESLSAR EFLQHASIDF KHKLWYLLLD AYNESGEKRI SVDGYIEMLT SLSYELETAG
     YRNMNPNQRH TILLRTLSTM NDTVGNLAKI CRDTPALLES VSREKIHELA QLCLSFLRLL
     QVFNQFYDRR NPEEPTPFLW DKASEKFQTM MVKLWTFFYL LFRQLTNGLD ENLPQTTIST
     LNDILSIVHE DLGHRKCCSF ANGIFVDLTL DEIVRMKWNE SEADLLQNIR CRFGIQLANE
     HYHPTDHGAT PRALKRSDGL AFQDFIMNMV YRKPSSVHNI RADLRAVMDQ LYEAIGDPDK
     NIASTSHNMT VLGRFTVAPV TWNYIENSLR GESFLPFMTS TDPVLSASTG GFYCVQGMLA
     LAKFRQGKKA AAPGRTEDLQ AAVKFFTNDI LCCPTRYESW FGIANAYEML TEDDLMWSAE
     KLDVPNSIVN INQRKALLCG LNSVNLMLQQ RDEKPANPQL RTFFNAVMKE SQWLFLSKLF
     YSATANPLHG ASFRQADNKI FCGMKGLYMR QNLSLPRRKQ CYQVVRACLT ISINSKDQPP
     DWYSYYLRSK VYSKLKKTTQ AILGDIQKSI AVAPDKINGD ILLEPHYKLV AYLYKAVKRG
     KLTAAEAYKE LKKTPHFVEY LGEDADMESG DDSDSDSEVG SDSETESTKE GPIASATEPA
     ADTAPPVVPS EGTSGSPISI DDATPVPGPV TAVTAIAAPP TVAAKPEEKK KPLTRMEIKF
     YKSCIETLRR MKVLDKRKWH HRPPFLIARI HKEVFEDYRS AKEEMVPFFN LKNQSKAPVH
     IWKPDFERAG KHFQYVFDYL MFFIVLLDKT DDTDAITTIG KKLRRFNNGM VNHFEVWEFT
     CLTSNVLMKR VTRIPEKLPD AIIPSLQFDN FDRIAQGLQD KITKSKEPAS YLLSLLYYAS
     EFRRLNNGFG STGVVDDTVV CLYLKMLIEY AGTSLLADNK SRSSTPVVLD GAKFEFQPGS
     AQPPALPAPA TTATTAGKKE DGKKEKTRVT RKDILLRATN LIKACSNKVG ENIKLVTTKG
     PPAVASSNGS SSNSGTRSNS EEKEKEPTEE PEKSTQDSDV EMADANQGNT ETTVEPEAEG
     EADKSAEEDK SDKSAEEEKT DKFAEEEKSA SAEPAGKNTP KSKSTGSNGV ITIDEEYSAP
     E