ID   HIR4_ARATH              Reviewed;         292 AA.
AC   Q9FHM7;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Hypersensitive-induced response protein 4;
DE            Short=AtHIR4;
GN   Name=HIR4; OrderedLocusNames=At5g51570; ORFNames=K17N15.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=17644812; DOI=10.1074/mcp.m700099-mcp200;
RA   Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J.,
RA   Barbier-Brygoo H., Ephritikhine G.;
RT   "A high content in lipid-modified peripheral proteins and integral receptor
RT   kinases features in the arabidopsis plasma membrane proteome.";
RL   Mol. Cell. Proteomics 6:1980-1996(2007).
RN   [6]
RP   INTERACTION WITH RESISTANCE PROTEINS, SUBUNIT, AND SUBCELLULAR LOCATION.
RA   Qi Y., Katagiri F.;
RT   "New classes of proteins forming complexes with resistance proteins.";
RL   (In) Proceedings of the 20th international conference on Arabidopsis
RL   research, abstract#501734213, Edinburgh (2009).
CC   -!- SUBUNIT: Self-interacts and forms heteromers. Interacts with NB-LRR
CC       class of R proteins before R proteins (e.g. RPS2 or RPM1) are activated
CC       by the effectors. {ECO:0000269|Ref.6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:17644812,
CC       ECO:0000305|Ref.6}; Lipid-anchor {ECO:0000305}; Cytoplasmic side
CC       {ECO:0000305|PubMed:17644812, ECO:0000305|Ref.6}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB018109; BAB08673.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96099.1; -; Genomic_DNA.
DR   EMBL; BT006203; AAP12852.1; -; mRNA.
DR   EMBL; AK227961; BAE99929.1; -; mRNA.
DR   RefSeq; NP_199970.1; NM_124536.4.
DR   AlphaFoldDB; Q9FHM7; -.
DR   SMR; Q9FHM7; -.
DR   BioGRID; 20476; 5.
DR   IntAct; Q9FHM7; 1.
DR   STRING; 3702.AT5G51570.1; -.
DR   SwissPalm; Q9FHM7; -.
DR   PaxDb; Q9FHM7; -.
DR   PRIDE; Q9FHM7; -.
DR   ProteomicsDB; 230191; -.
DR   EnsemblPlants; AT5G51570.1; AT5G51570.1; AT5G51570.
DR   GeneID; 835231; -.
DR   Gramene; AT5G51570.1; AT5G51570.1; AT5G51570.
DR   KEGG; ath:AT5G51570; -.
DR   Araport; AT5G51570; -.
DR   TAIR; locus:2153117; AT5G51570.
DR   eggNOG; KOG2620; Eukaryota.
DR   HOGENOM; CLU_024949_5_1_1; -.
DR   InParanoid; Q9FHM7; -.
DR   OMA; AMTQQMK; -.
DR   OrthoDB; 1062075at2759; -.
DR   PhylomeDB; Q9FHM7; -.
DR   PRO; PR:Q9FHM7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FHM7; baseline and differential.
DR   Genevisible; Q9FHM7; AT.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0005773; C:vacuole; HDA:TAIR.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..292
FT                   /note="Hypersensitive-induced response protein 4"
FT                   /id="PRO_0000398599"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   292 AA;  32378 MW;  685E778253D009A0 CRC64;
     MGNTYCILGG CIEQASVGVV ERWGRFEHIA EPGCHFFNPL AGQWLAGVLS TRIKSLDVKI
     ETKTKDNVFV QLVCSIQYRV VKASADDAFY ELQNPKEQIQ AYVFDVVRAL VPMMTLDALF
     EQKGEVAKSV LEELEKVMGA YGYSIEHILM VDIIPDPSVR KAMNEINAAQ RLQLASVYKG
     EAEKILQVKR AEAEAEAKYL GGVGVARQRQ AITDGLRENI LNFSDKVEGT SAKEVMDLIM
     ITQYFDTIRD LGNSSKNTTV FLPHGPGHVR DISDQIRNGM MEAAASTQVN DV