ID   HIRA_CAEEL              Reviewed;         935 AA.
AC   Q09589; C4ALD2; Q8IG07;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Protein HIRA {ECO:0000305};
DE   AltName: Full=Histone cell cycle regulator 1 homolog {ECO:0000312|WormBase:K10D2.1a};
GN   Name=hira-1 {ECO:0000312|WormBase:K10D2.1a};
GN   ORFNames=K10D2.1 {ECO:0000312|WormBase:K10D2.1a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; BX284603; CCD72864.1; -; Genomic_DNA.
DR   PIR; E88451; E88451.
DR   RefSeq; NP_498101.2; NM_065700.4.
DR   AlphaFoldDB; Q09589; -.
DR   SMR; Q09589; -.
DR   BioGRID; 40940; 4.
DR   DIP; DIP-26906N; -.
DR   STRING; 6239.K10D2.1a; -.
DR   EPD; Q09589; -.
DR   PaxDb; Q09589; -.
DR   PeptideAtlas; Q09589; -.
DR   EnsemblMetazoa; K10D2.1a.1; K10D2.1a.1; WBGene00019627.
DR   GeneID; 175709; -.
DR   KEGG; cel:CELE_K10D2.1; -.
DR   UCSC; K10D2.1a; c. elegans.
DR   CTD; 175709; -.
DR   WormBase; K10D2.1a; CE43736; WBGene00019627; hira-1.
DR   eggNOG; KOG0973; Eukaryota.
DR   GeneTree; ENSGT00550000074919; -.
DR   InParanoid; Q09589; -.
DR   OMA; NWVTHDG; -.
DR   OrthoDB; 685536at2759; -.
DR   PhylomeDB; Q09589; -.
DR   PRO; PR:Q09589; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00019627; Expressed in adult organism and 4 other tissues.
DR   ExpressionAtlas; Q09589; baseline and differential.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..935
FT                   /note="Protein HIRA"
FT                   /id="PRO_0000286424"
FT   REPEAT          14..58
FT                   /note="WD 1"
FT   REPEAT          72..111
FT                   /note="WD 2"
FT   REPEAT          131..170
FT                   /note="WD 3"
FT   REPEAT          174..213
FT                   /note="WD 4"
FT   REPEAT          222..261
FT                   /note="WD 5"
FT   REPEAT          277..320
FT                   /note="WD 6"
FT   REPEAT          325..362
FT                   /note="WD 7"
FT   REGION          431..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..474
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..541
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  103430 MW;  3EBFCAEB8B02A3B1 CRC64;
     MGDVYVTSPT FVGHDTGSIL AIDCHPSGKK FITCGQKART SNGLVVVWNA EPVLDKKKAS
     NENVPKLLFQ VESQSQSNSC RWSPDGKRFA FGSDDSSVSV WEYVGLINSM GSITGGAQNV
     ERYKECCVLR GHSMEVLTVE WSPNGKYLAS GSIDYRIIIY NARKLPDRIT VLNDIQLPVK
     GLSWDPIGKY LASLEGDKKL RFWATDSWQC VKSVTEPFES NIEETMLTRL DWSPDGKYLM
     TPAAVRSGKP LIKLIQRQTW KSDQFLAGHH KGTTCVRAMP RLIEANLKNG KRMQLTCAAV
     GSRDKSISIW VFPGTLKPLF VINNIFNHTV MDFAWCGRNL LACSQDGTVK VIHLSESVIG
     EMISNEAMSD LCYQIYSIRP PRYELTDKEE DESQDSFNLS DLSSSANNAS FVTCPEDVLI
     KRKKLVAAQQ SSDIQLTKSM EDNSKENESK NSEKTMMEER NKQIDVRKDG KRRIQPVFCG
     TTTADPMTSL SSEGKKTVAP PPAKRKALAP AVPAKKGEVD LEDSSDSDDD DEEEEEDMEI
     SDIESVRNKK RKVPATTSQP MLALDLKKPA LRPMEPKSLK TQEGTVLMEA PEQQPKLSQH
     VVDRKGMFVE IDNRWKHGGV ETTQIKLIKK KQQTAENEDD MMDGERRVNH ECLWMAVLGS
     PVIIVAANKH NVVLGCGDKC LRVYRTFCGT HIVSLRLDSL PVLIGVTEHA AYALTENGRL
     STWNLKLGKA VVTRQPLFDC VEASTDNSLI SADVSETGVP LIVFSNGSIF TFNVSLSCWI
     QAITTNVLGR LTSPISDAQL SCSNGTTNSA GPLVRLLKRM RKQATAPGVA PQVVKAVKES
     QLEQLLHCAE QLGNPQDYQT MLMLYVETLC EGGSEKKLKN ILNDLSRSGA PMQVCGLRRS
     ALYDDVTRMI KLKQPAIAAR IVAGVAASTT TKSLF