HIRA_DICDI
ID HIRA_DICDI Reviewed; 1114 AA.
AC Q86HX1; Q551L3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Protein HIRA;
GN Name=hira; ORFNames=DDB_G0276423;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for the periodic repression of histone gene
CC transcription during the cell cycle. Promotes replication-independent
CC chromatin assembly (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; AAFI02000015; EAL69165.1; -; Genomic_DNA.
DR RefSeq; XP_643117.1; XM_638025.1.
DR AlphaFoldDB; Q86HX1; -.
DR SMR; Q86HX1; -.
DR STRING; 44689.DDB0233325; -.
DR PaxDb; Q86HX1; -.
DR EnsemblProtists; EAL69165; EAL69165; DDB_G0276423.
DR GeneID; 8620522; -.
DR KEGG; ddi:DDB_G0276423; -.
DR dictyBase; DDB_G0276423; hira.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_0_0_1; -.
DR InParanoid; Q86HX1; -.
DR OMA; RGSWDGD; -.
DR PhylomeDB; Q86HX1; -.
DR PRO; PR:Q86HX1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:dictyBase.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..1114
FT /note="Protein HIRA"
FT /id="PRO_0000327933"
FT REPEAT 10..50
FT /note="WD 1"
FT REPEAT 66..105
FT /note="WD 2"
FT REPEAT 119..158
FT /note="WD 3"
FT REPEAT 161..200
FT /note="WD 4"
FT REPEAT 209..251
FT /note="WD 5"
FT REPEAT 262..304
FT /note="WD 6"
FT REPEAT 308..347
FT /note="WD 7"
FT REGION 405..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 122740 MW; 16209E52DD147A0C CRC64;
MKILKPQWVS HGGLSIYSID IHPDGTRVAT GGGDAKIKIW SMAPISLLEA EEDAGIPKLL
CSIENAHFHS VNSVKWSKDG KYLASGSDDK LCMIWGLSNN NSLLKNTTEN WVCVATLRGH
ASDISEVSWS PDNKYIATCS FDKSIIIWET NKFQMVSKLE EHKGFVKGLT WDPLGRYLAS
QSEDKSLIIW RTSDWVVETI VTEPFKHSGN SFFLRPSWTP DGQFIVATHG INNATHTGVL
VSRTDWDIGL DLVGHRKAVV VSRCSSKIYK DFKSRDQKFC LILLGGQDST LSLWSSSSPR
SLMVTRSLFD QCIQDISWCS DGYSFVACST DGTVGYISLD PEEIGGSPIG PEEKQIFFKN
YYGDAVTIDK EGNVIYGAAG GNLSSAANSG SHAILPENPD QLAMEESNAN GVGSGVSGGG
VSGGGGSGSG INNQNGGENH SKTNSTSTLQ PTQLAMQNQK QTIMPGGKRR ITPIFIGSSS
QNITKPQPVA IPLHLQQLQH SSSSLKPTGN EPMETDSSTK TSSPSSSSSS TTTATTITEK
TATPTKMTPM VPFGLNKLNG TIDGSNDRFS HPRIKDNNNN HNHHIHHRDT HKSSHHDKSD
RDKSDRDDQS TKHTTPNIGG SNSNSNNSSK RRSAEPEPTI SISKKKKSSS GSNKQQQQQQ
QQQQTDQNQN SQFSNNNNNN NMIISTVIPT GFSIPLPTLT NKISKKLIDQ PIQASALNNR
LFPTMTPNTT TTSGVGGSII IDVNITEQEL QDNTVEYFSV IRYLSFETQL WENRIAGRIT
LITGNKNWCA ATTLDSLLYI FNKNGTIIMS NIVPRNQLSF LESNKTNHLL AITCDGFVCV
WNVLKKKVEL SNRELPFLKN RDSLTIKHAM VTEESGKPII TFSNGDSFVY SSDVGEWVKI
TDRLGALSEY NSNDTTNTGI LSTLQNNNRI NSIINSNITN NISNQQQQQQ QPSVSNLLSL
SNSESQQQQQ LSTSLFLEKQ LWLAQVLESS LEYKHWLLIY TKYLTNCCNI VKLTDLCTDL
LGPSSTLNDH HHHHHHHNHT TGMSMESNPF SNNSLSIPWE STILGLSKRS LLKEILPIMA
GNRTLQRMVG QFKESLNAFS KNILVDPFDT LLNK
