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HIRA_DROME
ID   HIRA_DROME              Reviewed;        1047 AA.
AC   O17468; O46105; O77144; Q5U0S5; Q8T0C3; Q9W3Q3;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 183.
DE   RecName: Full=Protein HIRA homolog;
DE   AltName: Full=Protein sesame;
DE   AltName: Full=dHIRA;
GN   Name=Hira; Synonyms=Dhh, ssm; ORFNames=CG12153;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9611274; DOI=10.1016/s0378-1119(98)00143-7;
RA   Kirov N., Shtilbans A., Rushlow C.;
RT   "Isolation and characterization of a new gene encoding a member of the HIRA
RT   family of proteins from Drosophila melanogaster.";
RL   Gene 212:323-332(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9712723; DOI=10.1006/bbrc.1998.9165;
RA   Llevadot R., Marques G., Pritchard M., Estivill X., Ferrus A., Scambler P.;
RT   "Cloning, chromosome mapping and expression analysis of the HIRA gene from
RT   Drosophila melanogaster.";
RL   Biochem. Biophys. Res. Commun. 249:486-491(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Berkeley; TISSUE=Testis;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   FUNCTION.
RX   PubMed=10837127; DOI=10.1006/dbio.2000.9718;
RA   Loppin B., Docquier M., Bonneton F., Couble P.;
RT   "The maternal effect mutation sesame affects the formation of the male
RT   pronucleus in Drosophila melanogaster.";
RL   Dev. Biol. 222:392-404(2000).
RN   [8]
RP   FUNCTION.
RX   PubMed=11735001; DOI=10.1007/s004120100161;
RA   Loppin B., Berger F., Couble P.;
RT   "The Drosophila maternal gene sesame is required for sperm chromatin
RT   remodeling at fertilization.";
RL   Chromosoma 110:430-440(2001).
RN   [9]
RP   FUNCTION.
RX   PubMed=15988027; DOI=10.1128/mcb.25.14.6165-6177.2005;
RA   Jayaramaiah Raja S., Renkawitz-Pohl R.;
RT   "Replacement by Drosophila melanogaster protamines and Mst77F of histones
RT   during chromatin condensation in late spermatids and role of sesame in the
RT   removal of these proteins from the male pronucleus.";
RL   Mol. Cell. Biol. 25:6165-6177(2005).
RN   [10]
RP   ERRATUM OF PUBMED:15988027.
RA   Jayaramaiah Raja S., Renkawitz-Pohl R.;
RL   Mol. Cell. Biol. 26:3682-3682(2006).
RN   [11]
RP   FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ARG-225.
RX   PubMed=16251970; DOI=10.1038/nature04059;
RA   Loppin B., Bonnefoy E., Anselme C., Laurencon A., Karr T.L., Couble P.;
RT   "The histone H3.3 chaperone HIRA is essential for chromatin assembly in the
RT   male pronucleus.";
RL   Nature 437:1386-1390(2005).
RN   [12]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=17372656; DOI=10.1039/b617545g;
RA   Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA   Eng J.K., Aebersold R., Tao W.A.;
RT   "An integrated chemical, mass spectrometric and computational strategy for
RT   (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT   Kc167 cells.";
RL   Mol. Biosyst. 3:275-286(2007).
CC   -!- FUNCTION: Required for the periodic repression of histone gene
CC       transcription during the cell cycle (By similarity). Required for
CC       replication-independent chromatin assembly. Promotes remodeling of
CC       sperm chromatin following fertilization via the incorporation of
CC       histone H3.3 and histone H4. {ECO:0000250, ECO:0000269|PubMed:10837127,
CC       ECO:0000269|PubMed:11735001, ECO:0000269|PubMed:15988027,
CC       ECO:0000269|PubMed:16251970}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16251970}.
CC       Note=Maternally contributed protein localizes specifically to the male
CC       nucleus in fertilized eggs. This localization persists from the
CC       initiation of sperm nucleus decondensation to the end of pronucleus
CC       formation.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Long;
CC         IsoId=O17468-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=O17468-2; Sequence=VSP_006775, VSP_006776, VSP_006777;
CC       Name=3;
CC         IsoId=O17468-3; Sequence=VSP_006776, VSP_006777;
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally and zygotically throughout
CC       development to adults (male and female). {ECO:0000269|PubMed:9611274,
CC       ECO:0000269|PubMed:9712723}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be involved in protamine removal but
CC       this was shown to be incorrect in the subsequent published erratum.
CC       {ECO:0000269|Ref.10}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC48360.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF031081; AAC48360.1; ALT_FRAME; mRNA.
DR   EMBL; AJ222709; CAA10954.1; -; mRNA.
DR   EMBL; AF071881; AAC64041.1; -; mRNA.
DR   EMBL; AE014298; AAF46267.1; -; Genomic_DNA.
DR   EMBL; AY069414; AAL39559.1; -; mRNA.
DR   EMBL; BT016167; AAV37052.1; -; mRNA.
DR   PIR; A59246; A59246.
DR   RefSeq; NP_572401.2; NM_132173.3. [O17468-1]
DR   AlphaFoldDB; O17468; -.
DR   SMR; O17468; -.
DR   BioGRID; 58155; 24.
DR   IntAct; O17468; 2.
DR   STRING; 7227.FBpp0071028; -.
DR   iPTMnet; O17468; -.
DR   PaxDb; O17468; -.
DR   EnsemblMetazoa; FBtr0071070; FBpp0071028; FBgn0022786. [O17468-1]
DR   GeneID; 31680; -.
DR   KEGG; dme:Dmel_CG12153; -.
DR   CTD; 7290; -.
DR   FlyBase; FBgn0022786; Hira.
DR   VEuPathDB; VectorBase:FBgn0022786; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   GeneTree; ENSGT00550000074919; -.
DR   HOGENOM; CLU_004372_3_0_1; -.
DR   InParanoid; O17468; -.
DR   OMA; VHHDDKQ; -.
DR   PhylomeDB; O17468; -.
DR   SignaLink; O17468; -.
DR   BioGRID-ORCS; 31680; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Hira; fly.
DR   GenomeRNAi; 31680; -.
DR   PRO; PR:O17468; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0022786; Expressed in embryonic/larval hemocyte (Drosophila) and 20 other tissues.
DR   Genevisible; O17468; DM.
DR   GO; GO:0042585; C:germinal vesicle; IDA:FlyBase.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0001673; C:male germ cell nucleus; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR   GO; GO:0006338; P:chromatin remodeling; IMP:FlyBase.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IMP:FlyBase.
DR   GO; GO:0035042; P:fertilization, exchange of chromosomal proteins; IMP:FlyBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0035041; P:sperm DNA decondensation; IMP:FlyBase.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Chromatin regulator; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..1047
FT                   /note="Protein HIRA homolog"
FT                   /id="PRO_0000051022"
FT   REPEAT          11..53
FT                   /note="WD 1"
FT   REPEAT          68..107
FT                   /note="WD 2"
FT   REPEAT          127..166
FT                   /note="WD 3"
FT   REPEAT          170..209
FT                   /note="WD 4"
FT   REPEAT          218..263
FT                   /note="WD 5"
FT   REPEAT          264..319
FT                   /note="WD 6"
FT   REPEAT          323..364
FT                   /note="WD 7"
FT   REGION          401..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          882..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..1047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..526
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..905
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..988
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1003..1047
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         519
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:17372656"
FT   VAR_SEQ         63
FT                   /note="L -> LPVLSDKAEFDADVPKML (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:9712723"
FT                   /id="VSP_006775"
FT   VAR_SEQ         430..437
FT                   /note="KDGKRRIT -> LSLICKIF (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12537569,
FT                   ECO:0000303|PubMed:9712723"
FT                   /id="VSP_006776"
FT   VAR_SEQ         438..1047
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12537569,
FT                   ECO:0000303|PubMed:9712723"
FT                   /id="VSP_006777"
FT   MUTAGEN         225
FT                   /note="R->K: In allele ssm; maternal effect embryonic
FT                   lethal mutation which impairs maternal histone deposition
FT                   in the male pronucleus."
FT                   /evidence="ECO:0000269|PubMed:16251970"
FT   CONFLICT        53
FT                   /note="A -> G (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="D -> E (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="C -> G (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="C -> S (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159..163
FT                   /note="QAFPH -> RHFHN (in Ref. 2; AAC64041)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="K -> E (in Ref. 2; AAC64041)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="S -> W (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        232
FT                   /note="G -> A (in Ref. 2; AAC64041)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        242
FT                   /note="N -> D (in Ref. 2; CAA10954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        330
FT                   /note="D -> Y (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        416
FT                   /note="A -> V (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        417
FT                   /note="N -> I (in Ref. 6; AAV37052)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        451
FT                   /note="L -> M (in Ref. 6; AAV37052)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        453..455
FT                   /note="MNI -> LNF (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        459
FT                   /note="S -> R (in Ref. 2; CAA10954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        536
FT                   /note="L -> V (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        830
FT                   /note="S -> T (in Ref. 6; AAV37052)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        890..892
FT                   /note="QKT -> PKA (in Ref. 6; AAV37052)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1043
FT                   /note="K -> Q (in Ref. 1; AAC48360)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1047 AA;  113415 MW;  3614D5F411DC440C CRC64;
     MRLLKPAWVH HDDKQIFSVD IHKDCTKFAT GGQGSDCGRV VIWNLLPVLS DKAEFDADVP
     KMLCQMDQHL ACVNCVRWSQ NGQNLASGSD DKLIMIWRKS AGSSGVFGTG GMQKNHESWK
     CFYTLRGHDG DVLDLAWSPN DVYLASCSID NTVIIWDAQA FPHSVATLKG HTGLVKGVSW
     DPLGRFLASQ SDDRSIKIWN TMNWSLSHTI TEPFEECGGT THILRLSWSP DGQYLVSAHA
     MNGGGPTAQI IEREGWKCDK DFVGHRKAVT CVRFHNSILS RQENDGSPSK PLQYCCLAVG
     SRDRSLSVWM TALQRPMVVI HELFNASILD LTWGPQECLL MACSVDGSIA CLKFTEEELG
     KAISEEEQNA IIRKMYGKNY VNGLGKSAPV LEHPQRLLLP QGDKPTKFPL SNNNEANQRP
     ISKQTETRTK DGKRRITPMF IPLHEDGPTS LSMNIVSSSG SSTTALTSCS AAIGTLPAAA
     PTESAATPLM PLEPLVSKID LGRLDSRLKT QPASQRRQSL PFDPGQSNEL LRTPRLEEHQ
     SSTCSPSNLN VTATGKSEFV KAALDYRLHV SNGHLKTQHG MLAKVTASDS KEMLWEFYVG
     SPLVNLNLCE KYAMLCSLDG SMRLISMETG CPVFPAISLT SSAVHCAFSP DNSLVGVLTE
     CGLLRIWDIA KKVVSLAAGC LELLNKHGTA AQFSVTNQGM PLIGFPSGNS YSYSTSLQSW
     LVLATKDAIM YHGIRGTLPR DMDQMQQKFP LLSMQASSQN YFSFTGSMEL RHSESWQQCA
     KIRFIENQIK LCEALQSLDE LQHWHKMLTF QLATHGSEKR MRVFLDDLLS MPEPGISQFV
     PKLELMQCVL DTLKPHSEWN RLHSEYTELL KECKSERQKD IFATPAPPQQ KTASSAGSSP
     RSGEATGEEV TEKDGATAVA AAVVAGSRMA VTTGTSTTTT TTASSSLSSS GSSSSTSGSG
     SSSSSSSTSS LSVPQPAPSL SPEIQTLDSP TVCIDDEILS ASSSLPPLDT SPVEVSPAST
     SGGAASTSPA ASVAGSAPVS SSKTDQT
 
 
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