ID   HIRA_MAIZE              Reviewed;         964 AA.
AC   Q32SG6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Protein HIRA;
DE   AltName: Full=Histone regulator protein;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR
RP   LOCATION, AND INTERACTION WITH RS2.
RC   STRAIN=cv. B73; TISSUE=Apices;
RX   PubMed=16243907; DOI=10.1105/tpc.105.035477;
RA   Phelps-Durr T.L., Thomas J., Vahab P., Timmermans M.C.P.;
RT   "Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1
RT   interact with HIRA, a predicted histone chaperone, to maintain knox gene
RT   silencing and determinacy during organogenesis.";
RL   Plant Cell 17:2886-2898(2005).
CC   -!- FUNCTION: Histone chaperone involved in maintining knox genes silencing
CC       throughout leaf development. {ECO:0000250,
CC       ECO:0000269|PubMed:16243907}.
CC   -!- SUBUNIT: Interacts with RS2. {ECO:0000269|PubMed:16243907}.
CC   -!- INTERACTION:
CC       Q32SG6; Q9S7B2: RS2; NbExp=2; IntAct=EBI-761318, EBI-761350;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16243907}.
CC   -!- TISSUE SPECIFICITY: More abundant in apices and young leaf primordia
CC       than in fully expanded leaf tissues. {ECO:0000269|PubMed:16243907}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; AY940678; AAY24681.1; -; mRNA.
DR   AlphaFoldDB; Q32SG6; -.
DR   SMR; Q32SG6; -.
DR   IntAct; Q32SG6; 2.
DR   STRING; 4577.GRMZM2G428515_P01; -.
DR   PaxDb; Q32SG6; -.
DR   PRIDE; Q32SG6; -.
DR   Proteomes; UP000007305; Unplaced.
DR   ExpressionAtlas; Q32SG6; baseline and differential.
DR   GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Coiled coil; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..964
FT                   /note="Protein HIRA"
FT                   /id="PRO_0000299133"
FT   REPEAT          10..50
FT                   /note="WD 1"
FT   REPEAT          64..103
FT                   /note="WD 2"
FT   REPEAT          123..162
FT                   /note="WD 3"
FT   REPEAT          165..204
FT                   /note="WD 4"
FT   REPEAT          259..331
FT                   /note="WD 5"
FT   REPEAT          335..376
FT                   /note="WD 6"
FT   REPEAT          644..685
FT                   /note="WD 7"
FT   REGION          453..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          920..940
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   964 AA;  105566 MW;  DC92F705D53B8B20 CRC64;
     MILEKPSWIR HEGLQIFSID IQTGGLRFAT GGGDQKVRIW SMESVHKDNT NNDSKQRLLA
     TLRDHFGSVN CVRWAKHGRY LASGSDDQVI LIHERKAGSG TSEFGSGEPP DAENWKVIMT
     WRGHTADVVD LSWSPDDSTL ASGSLDNTIH IWNMNNGICT AVLRGHTSLV KGVTWDPIGS
     FIASQSDDKT VMIWRTSDWS LAHKTEGHWT KSLGSTFFRR LAWSPCCHFI TTTHGFQKPR
     HSAPVLERGE WAATFDFLGH NAPIVVVKFN NSTFRKNFSS DQDPKAAPVG WANGASKTPT
     KEQQPYNVIA IGSQDRTITV WTTASARPLF VARHFFSQSV VDLSWSPDGY SLFACSLDGS
     AANFHFEVKE LGHRLSDSEM DEWKRNRYGD VGGRQSNLAE SPAQLLLEQA SAKQSAGEKV
     TSIVEQGKAP PKVSAGVPNP GLVVLSLEVP EVSHEDSKKT AGPTADDVKK GNQLSSPVKQ
     REYRRPDGRK RIIPEAVGFA SNQDNIPNHS QNHPVNFSSL DQRMNGTKPS YGSNSNSNNC
     GVKDRTSVTA RANITESLVI QKASAGAGND GRLSIEHTRS MAPSSLTPCS ALSIHVINKN
     GNEDALPVCL EARPVERGAG DMIGVGALST KETEIKCIKG TKTLWSDRIS GKVTVLAGNA
     NFWAVGCEDG FLQVYTRCGV RAMPAMMMGS AAVFIDCDDS WKLLLVTGRG LMYIWNLYDR
     ACILHDSLAS LVASPDESSA KDAGTVKVIS ATFSRCGSPL VALASRHAFL YDMSLKCWLR
     IADDCFPASN FASSFSFPQG GELGKLQIDI GKFMARKPIW SRVTDDGLQT RAHLENQLAS
     SLALKSAQEY RQCLLSYVRF LAREADESRL REVCESFLGP PMGKVGSASP TDPKNLAWDP
     DVLGMKKHKL LKEDILPSMA SNRKVQRLLN EFMDLLLEYE TDVTLIPQPG TEGNGNGNDK
     VMTS