HIRA_XENLA
ID HIRA_XENLA Reviewed; 1013 AA.
AC Q8QFR2; Q6DCK6; Q90YE6; Q90YE7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Protein HIRA;
GN Name=hira; Synonyms=hira-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HISTONE H2A; HISTONE
RP H2B; HISTONE H3 AND HISTONE H4, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Oocyte;
RX PubMed=12049744; DOI=10.1016/s1097-2765(02)00526-9;
RA Ray-Gallet D., Quivy J.-P., Scamps C., Martini E.M.-D., Lipinski M.,
RA Almouzni G.;
RT "HIRA is critical for a nucleosome assembly pathway independent of DNA
RT synthesis.";
RL Mol. Cell 9:1091-1100(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=14718166; DOI=10.1016/s0092-8674(03)01064-x;
RA Tagami H., Ray-Gallet D., Almouzni G., Nakatani Y.;
RT "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways
RT dependent or independent of DNA synthesis.";
RL Cell 116:51-61(2004).
CC -!- FUNCTION: Required for the periodic repression of histone gene
CC transcription during the cell cycle (By similarity). Required for
CC replication-independent chromatin assembly. {ECO:0000250,
CC ECO:0000269|PubMed:12049744, ECO:0000269|PubMed:14718166}.
CC -!- SUBUNIT: Interacts with histone H2A, histone H2B, histone H3 and
CC histone H4. {ECO:0000269|PubMed:12049744}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12049744}.
CC -!- DEVELOPMENTAL STAGE: Expressed during oogenesis from stage IV onwards
CC and throughout early embryonic development.
CC {ECO:0000269|PubMed:12049744}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; AJ278386; CAC41092.1; -; mRNA.
DR EMBL; AJ278387; CAC41093.1; -; mRNA.
DR EMBL; AJ404369; CAC81987.1; -; mRNA.
DR EMBL; BC078007; AAH78007.1; -; mRNA.
DR AlphaFoldDB; Q8QFR2; -.
DR SMR; Q8QFR2; -.
DR BioGRID; 98943; 3.
DR IntAct; Q8QFR2; 1.
DR MaxQB; Q8QFR2; -.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 2.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1013
FT /note="Protein HIRA"
FT /id="PRO_0000286423"
FT REPEAT 11..53
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 129..168
FT /note="WD 3"
FT REPEAT 172..211
FT /note="WD 4"
FT REPEAT 220..263
FT /note="WD 5"
FT REPEAT 266..322
FT /note="WD 6"
FT REPEAT 326..367
FT /note="WD 7"
FT REGION 529..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 39
FT /note="K -> E (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
FT CONFLICT 72
FT /note="C -> R (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="S -> P (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="G -> S (in Ref. 1; CAC41092)"
FT /evidence="ECO:0000305"
FT CONFLICT 637
FT /note="K -> R (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
FT CONFLICT 647
FT /note="R -> K (in Ref. 1; CAC41092)"
FT /evidence="ECO:0000305"
FT CONFLICT 720
FT /note="H -> R (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
FT CONFLICT 903
FT /note="P -> S (in Ref. 1; CAC81987)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1013 AA; 112040 MW; 283F5B49466F20D1 CRC64;
MKLLKPSWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMPPMLK EEDEKNENIP
KMLCQMDNHL ACVNCVRWSN NGAYLASGGD DKLIMVWKRS GYIGPSTVFG SSSKLANVEQ
WRCLSILRSH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA LKFPEIISTL RGHSGLVKGL
TWDPVGKYIA SQADDHSIKV WRTMDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA
HAMNNSGPTA QIIERDGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKTSCPYCCC
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAYLDFSQD
ELGDPLSEEE KNNIHQSTYG KSLAITTEPQ LPNTVIENPE MLKFQQRQQL QQDGEHMVQA
QMEAPIHNMA SMMNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSTAFFN
SIPISGSLPG SMMSSQSNQQ LISLDSNTTS SSGALKSNVE LVGNNTKPAE ETANKESGNV
SSSSPVAPTS ITAQPKIEPM KALDSRFTER SKATSGTAGV AHLNQTAVDR LKEQNVTKDS
KPRVVESSSD SEEKIPASKQ LSKRKGEADA DLAEKRKKGR PRKESQRLMS VSLTVQSQVA
STSEKELTCV TTSSLTLRLP TPTPQKSFTL QLSSDPSMYI EVENEVKTVG GNKLSQLKCH
REGKEWEAVL TSRIVAAAGS KEVVCVACEK RMLSIFSGSG RRIFPPIILP SPISTLQCTG
SYVMALTAAA ALSVWDVQNQ NIIIKNESLQ PLLSGNDLTV SQTLLTKRGI PVLSLSNGKA
YCFSPSLSTW SLVSDKQDSL AQCADYRSCM PSQDAVMCSG PLAIIQGRVS NAGRQAAHLF
TMPHLVQKET TMAYLENQVA AALMLQSSQE YRHWLLIYAQ YLVNEGFEQR LREVCQDLLG
PVHRSSDSQW ESRILGLWKR ELLKELLPLI GQNLRFQRLF TEYQEQLDIL RDK
