HIRP3_MOUSE
ID HIRP3_MOUSE Reviewed; 601 AA.
AC Q8BLH7; Q3TSF3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=HIRA-interacting protein 3;
GN Name=Hirip3 {ECO:0000312|MGI:MGI:2142364};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC32232.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC32232.1};
RC TISSUE=Egg {ECO:0000312|EMBL:BAE36722.1}, and
RC Embryo {ECO:0000312|EMBL:BAC32232.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:EDL17468.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAH55687.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH55687.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH55687.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-207 AND SER-208, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Teratocarcinoma;
RX PubMed=17622165; DOI=10.1021/pr070122r;
RA Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
RT "A differential phosphoproteomic analysis of retinoic acid-treated P19
RT cells.";
RL J. Proteome Res. 6:3174-3186(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141; SER-231 AND SER-234, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; THR-135; THR-141;
RP SER-152; SER-153; SER-163; THR-167; SER-231; SER-234; SER-238; SER-389;
RP THR-391; SER-564 AND SER-575, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in chromatin function and histone metabolism
CC via its interaction with HIRA and histones.
CC {ECO:0000250|UniProtKB:Q9BW71}.
CC -!- SUBUNIT: Interacts with HIRA. Weak interaction with histones H2B and
CC H3. Interacts with CK2 (By similarity). {ECO:0000250|UniProtKB:Q9BW71}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW71}.
CC Note=Nuclear throughout the cell cycle and is excluded from condensed
CC chromatin during mitosis. {ECO:0000250|UniProtKB:Q9BW71}.
CC -!- PTM: Phosphorylated by CK2. {ECO:0000250|UniProtKB:Q9BW71}.
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DR EMBL; AK045122; BAC32232.1; -; mRNA.
DR EMBL; AK162096; BAE36722.1; -; mRNA.
DR EMBL; CH466531; EDL17468.1; -; Genomic_DNA.
DR EMBL; BC055687; AAH55687.1; -; mRNA.
DR CCDS; CCDS21849.1; -.
DR RefSeq; NP_766334.1; NM_172746.3.
DR AlphaFoldDB; Q8BLH7; -.
DR SMR; Q8BLH7; -.
DR BioGRID; 231462; 3.
DR STRING; 10090.ENSMUSP00000035535; -.
DR iPTMnet; Q8BLH7; -.
DR PhosphoSitePlus; Q8BLH7; -.
DR EPD; Q8BLH7; -.
DR jPOST; Q8BLH7; -.
DR MaxQB; Q8BLH7; -.
DR PaxDb; Q8BLH7; -.
DR PeptideAtlas; Q8BLH7; -.
DR PRIDE; Q8BLH7; -.
DR ProteomicsDB; 273175; -.
DR Antibodypedia; 26925; 195 antibodies from 28 providers.
DR DNASU; 233876; -.
DR Ensembl; ENSMUST00000037248; ENSMUSP00000035535; ENSMUSG00000042606.
DR GeneID; 233876; -.
DR KEGG; mmu:233876; -.
DR UCSC; uc012ftw.1; mouse.
DR CTD; 8479; -.
DR MGI; MGI:2142364; Hirip3.
DR VEuPathDB; HostDB:ENSMUSG00000042606; -.
DR eggNOG; ENOG502S0AG; Eukaryota.
DR GeneTree; ENSGT00390000014062; -.
DR HOGENOM; CLU_038583_0_0_1; -.
DR InParanoid; Q8BLH7; -.
DR OMA; QAPPDWS; -.
DR OrthoDB; 879744at2759; -.
DR PhylomeDB; Q8BLH7; -.
DR TreeFam; TF331753; -.
DR BioGRID-ORCS; 233876; 8 hits in 73 CRISPR screens.
DR ChiTaRS; Hirip3; mouse.
DR PRO; PR:Q8BLH7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BLH7; protein.
DR Bgee; ENSMUSG00000042606; Expressed in animal zygote and 219 other tissues.
DR ExpressionAtlas; Q8BLH7; baseline and differential.
DR Genevisible; Q8BLH7; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR037647; HIRIP3.
DR InterPro; IPR019098; Histone_chaperone_domain_CHZ.
DR PANTHER; PTHR15410; PTHR15410; 2.
DR Pfam; PF09649; CHZ; 1.
DR SMART; SM01082; CHZ; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..601
FT /note="HIRA-interacting protein 3"
FT /id="PRO_0000367046"
FT REGION 60..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 134
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 135
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 141
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 167
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 205
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17622165"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17622165"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17622165"
FT MOD_RES 231
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 359
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 360
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 389
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 391
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 396
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 398
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 564
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 575
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 595
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 596
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
FT MOD_RES 600
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW71"
SQ SEQUENCE 601 AA; 65215 MW; F5422EE8F9B92B88 CRC64;
MAPGDEMRKF TRSFFRACPD LSSVTHAIVR QKFLIHVGRD HLEPEEKQAL KRLVEEELPK
MQADAGTREG KPDFIKVKRS PAPCSDPKKK RFRFNSESES SSSPSSPDGS GPSTKNRTTK
KTCLRRALKK AVESTDEDHQ TDLDAKMGLE ESSEGEAEGS VRSGKVTEEE EDMKQEQKGQ
VRKQAGAKDK QVPLKADRKQ VREESGSSEE EAVLQRAKVE GSTGANCQEE SEESGEESPA
KKKELSEPRS RSNRAERTAR ERKSYKQKSR PGRPTGGLRD SEAEKEGGTV GSGDSSEEGE
AEKEGGTVGS GDSSEKGEAE KEEGTVGSGD SSEEGEEHSV KRKSKVRTQT ESGRRQNTSS
RDDSNSTQEQ AAAQGTTKSG SLGSSNGDSD TEREVSDSQA GQNTKEERKS RSSNKSSKNG
QARSCSSSSD SSPEPTGQKG KARSSSSSSD SGPEPTGRKA ASRCGEDHPA VARLKRYIRA
CGAHRNYKKL LGSCSSHKAR LSVLRAELEA LGMKGNPSLE KCRALKLQRE EAAEVAALDV
ANIISSTGRP RRRNAWNPSG EGTSPGETYR RTLDSEEEQP RQAPPDWSHM RDIISSDGDS
S
