ID   3SIYL_DENAN             Reviewed;          86 AA.
AC   P17696;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Synergistic-like venom protein;
DE   Flags: Precursor;
OS   Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8618;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=2326204; DOI=10.1093/nar/18.6.1639;
RA   Rowan E., Ducancel F., Doljansky Y., Harvey A., Menez A., Boulain J.-C.;
RT   "Nucleotide sequence encoding a 'synergistic-like' protein from the venom
RT   glands of Dendroaspis angusticeps.";
RL   Nucleic Acids Res. 18:1639-1639(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:2326204}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:2326204}.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 54 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Aminergic toxin sub-subfamily. {ECO:0000305}.
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DR   EMBL; X51467; CAA35830.1; -; mRNA.
DR   PIR; S09235; V6EP9A.
DR   AlphaFoldDB; P17696; -.
DR   SMR; P17696; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..86
FT                   /note="Synergistic-like venom protein"
FT                   /id="PRO_0000035467"
FT   DISULFID        24..45
FT                   /evidence="ECO:0000250|UniProtKB:P0DQP2"
FT   DISULFID        38..63
FT                   /evidence="ECO:0000250|UniProtKB:P0DQP2"
FT   DISULFID        67..78
FT                   /evidence="ECO:0000250|UniProtKB:P0DQP2"
FT   DISULFID        75
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250|UniProtKB:P0DQP2"
FT   DISULFID        79..84
FT                   /evidence="ECO:0000250|UniProtKB:P0DQP2"
SQ   SEQUENCE   86 AA;  9307 MW;  11C0FE1F5C387DB8 CRC64;
     MKTLLLTLVV VTIVCLDLGY TLTCVTGKSI GGISTEECAA GQKICFKKWT KMGPKLYDVS
     RGCTATCPKA DEYGCVKCCK TDRCNK