ID   HIS1_MACFA              Reviewed;          38 AA.
AC   P34084;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Histatin-1;
GN   Name=HTN1;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   PROTEIN SEQUENCE, AND PHOSPHORYLATION AT SER-2.
RC   TISSUE=Parotid gland;
RX   PubMed=2229609; DOI=10.1177/00220345900690110301;
RA   Xu T., Telser E., Troxler R.F., Oppenheim F.G.;
RT   "Primary structure and anticandidal activity of the major histatin from
RT   parotid secretion of the subhuman primate, Macaca fascicularis.";
RL   J. Dent. Res. 69:1717-1723(1990).
CC   -!- FUNCTION: Histatins are salivary proteins that are considered to be
CC       major precursors of the protective proteinaceous structure on tooth
CC       surfaces (enamel pellicle). In addition, histatins exhibit
CC       antibacterial and antifungal activities.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the histatin/statherin family. {ECO:0000305}.
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DR   PIR; A60736; A60736.
DR   AlphaFoldDB; P34084; -.
DR   iPTMnet; P34084; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Biomineralization; Direct protein sequencing;
KW   Fungicide; Phosphoprotein; Reference proteome; Secreted.
FT   PEPTIDE         1..38
FT                   /note="Histatin-1"
FT                   /id="PRO_0000044777"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..28
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2229609"
SQ   SEQUENCE   38 AA;  4803 MW;  CBE4B381932FB63C CRC64;
     DSHEERHHGR HGHHKYGRKF HEKHHSHRGY RSNYLYDN