HIS42_PHOLL
ID HIS42_PHOLL Reviewed; 258 AA.
AC Q7N8D1;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2;
DE EC=5.3.1.16;
DE AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 2;
GN Name=hisA2; OrderedLocusNames=plu0797;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-
CC ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-
CC phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-
CC ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469,
CC ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000305}.
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DR EMBL; BX571861; CAE13092.1; -; Genomic_DNA.
DR RefSeq; WP_011145171.1; NC_005126.1.
DR AlphaFoldDB; Q7N8D1; -.
DR SMR; Q7N8D1; -.
DR STRING; 243265.plu0797; -.
DR EnsemblBacteria; CAE13092; CAE13092; plu0797.
DR GeneID; 24167850; -.
DR KEGG; plu:plu0797; -.
DR eggNOG; COG0106; Bacteria.
DR HOGENOM; CLU_048577_1_1_6; -.
DR OMA; ERGGMMS; -.
DR OrthoDB; 794219at2; -.
DR BioCyc; PLUM243265:PLU_RS03970-MON; -.
DR UniPathway; UPA00031; UER00009.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04732; HisA; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01014; HisA; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR023016; Isoase_HisA-like_bact.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR43090; PTHR43090; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Isomerase;
KW Reference proteome.
FT CHAIN 1..258
FT /note="1-(5-phosphoribosyl)-5-[(5-
FT phosphoribosylamino)methylideneamino] imidazole-4-
FT carboxamide isomerase 2"
FT /id="PRO_0000142032"
FT ACT_SITE 14
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 140
FT /note="Proton donor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 258 AA; 27350 MW; 0D890FE0FC66E410 CRC64;
MISKETFEIF PSVDIVDGIA MTSNSAIRLT RGESSTLRRP LGTPAEVALA WQNAGAKWIH
VVDLDAASGR GSNSHLIADV LAAVDINVQV CGGIRDETIL RKVLATGCQR VNLGTAALEN
PDWCAQAIAE YGDKIAIALD VKSTSEGYQL ATHGWNVSKG NLWDLLERLD KQGCQRYVVT
DVERGGMMSS PNFTLLQEVC AKTSSPVIAG GGVSSLDDLR ALADLSTIGV EGAILGQALH
IGKVPLEDAL AATQSPRR
