HIS4_LACLA
ID HIS4_LACLA Reviewed; 239 AA.
AC Q02131;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 3.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE EC=5.3.1.16;
DE AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN Name=hisA; OrderedLocusNames=LL1213; ORFNames=L0070;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCDO 2118;
RX PubMed=1400209; DOI=10.1128/jb.174.20.6571-6579.1992;
RA Delorme C., Ehrlich S.D., Renault P.;
RT "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis.";
RL J. Bacteriol. 174:6571-6579(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=7687248; DOI=10.1128/jb.175.14.4391-4399.1993;
RA Delorme C., Godon J.-J., Ehrlich S.D., Renault P.;
RT "Gene inactivation in Lactococcus lactis: histidine biosynthesis.";
RL J. Bacteriol. 175:4391-4399(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-
CC ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-
CC phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-
CC ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469,
CC ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000305}.
CC -!- CAUTION: This protein is inactive in the dairy strain IL1403. The
CC histidine biosynthesis pathway is not functional in the dairy strain
CC IL1403. {ECO:0000305}.
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DR EMBL; U92974; AAB81908.1; -; Genomic_DNA.
DR EMBL; AE005176; AAK05311.1; -; Genomic_DNA.
DR PIR; A47754; A47754.
DR PIR; E86776; E86776.
DR RefSeq; NP_267369.1; NC_002662.1.
DR AlphaFoldDB; Q02131; -.
DR SMR; Q02131; -.
DR STRING; 272623.L0070; -.
DR PaxDb; Q02131; -.
DR EnsemblBacteria; AAK05311; AAK05311; L0070.
DR KEGG; lla:L0070; -.
DR PATRIC; fig|272623.7.peg.1310; -.
DR eggNOG; COG0106; Bacteria.
DR HOGENOM; CLU_048577_1_2_9; -.
DR UniPathway; UPA00031; UER00009.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04732; HisA; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01014; HisA; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR006063; HisA_bact_arch.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR023016; Isoase_HisA-like_bact.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR43090; PTHR43090; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR TIGRFAMs; TIGR00007; TIGR00007; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Isomerase;
KW Reference proteome.
FT CHAIN 1..239
FT /note="1-(5-phosphoribosyl)-5-[(5-
FT phosphoribosylamino)methylideneamino] imidazole-4-
FT carboxamide isomerase"
FT /id="PRO_0000142012"
FT ACT_SITE 8
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 131
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT VARIANT 31
FT /note="N -> T (in strain: IL1403)"
FT VARIANT 54..56
FT /note="GAK -> DAN (in strain: IL1403)"
FT VARIANT 65
FT /note="L -> I (in strain: IL1403)"
FT VARIANT 71
FT /note="D -> E (in strain: IL1403)"
FT VARIANT 125..127
FT /note="RIV -> KII (in strain: IL1403)"
FT VARIANT 227
FT /note="G -> K (in strain: IL1403)"
FT CONFLICT 73
FT /note="T -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="N -> S (in Ref. 3; AAK05311)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 26896 MW; 6690A27AF8FB0411 CRC64;
MKIIPAIDLQ NGEAVRLYKG DYDKKTVYSK NPLEIAQKFE RMGATDLHLV DLDGAKIGQT
RNLELVRKIK DETRLKIEIG GGIRDFDTVR MYLEQIGVER VILGTAAVEK PDFLKELLIK
YGPSRIVVGV DIREGFVSTS GWLEKTSLPY LSFLKKLERI GVKTTIITDI SKDGTLTGPN
FKLYDEISKE NSLNVIISGG VKDNSDIQRA TRSDFYGIIV GKAYYEGKIN LEKEFRNAN
