ID   3SO62_NAJHH             Reviewed;          61 AA.
AC   P01415;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Weak toxin CM-2;
OS   Naja haje haje (Egyptian cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8642;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=710433; DOI=10.1111/j.1432-1033.1978.tb12612.x;
RA   Joubert F.J., Taljaard N.;
RT   "Naja haje haje (Egyptian cobra) venom. Some properties and the complete
RT   primary structure of three toxins (CM-2, CM-11 and CM-12).";
RL   Eur. J. Biochem. 90:359-367(1978).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:710433}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 16.1 mg/kg by subcutaneous injection.
CC       {ECO:0000269|PubMed:710433}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group VI sub-subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A01685; T2NJ2Y.
DR   AlphaFoldDB; P01415; -.
DR   SMR; P01415; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..61
FT                   /note="Weak toxin CM-2"
FT                   /evidence="ECO:0000269|PubMed:710433"
FT                   /id="PRO_0000093624"
FT   DISULFID        3..21
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        14..37
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        54..59
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   61 AA;  7033 MW;  0AE39B80AD634B11 CRC64;
     FTCFTTPSDT SETCPDGQNI CYEKRWNSHQ GVEIKGCVAS CPEFESRFRY LLCCRIDNCN
     K