ANMY1_MOUSE
ID ANMY1_MOUSE Reviewed; 906 AA.
AC Q8C0W1; Q0IJ76;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Ankyrin repeat and MYND domain-containing protein 1;
GN Name=Ankmy1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK029700; BAC26572.1; -; mRNA.
DR EMBL; BC120887; AAI20888.1; -; mRNA.
DR EMBL; BC120888; AAI20889.1; -; mRNA.
DR RefSeq; NP_766438.2; NM_172850.3.
DR AlphaFoldDB; Q8C0W1; -.
DR SMR; Q8C0W1; -.
DR STRING; 10090.ENSMUSP00000108622; -.
DR iPTMnet; Q8C0W1; -.
DR PhosphoSitePlus; Q8C0W1; -.
DR MaxQB; Q8C0W1; -.
DR PaxDb; Q8C0W1; -.
DR PRIDE; Q8C0W1; -.
DR ProteomicsDB; 281993; -.
DR DNASU; 241158; -.
DR GeneID; 241158; -.
DR KEGG; mmu:241158; -.
DR CTD; 51281; -.
DR MGI; MGI:3045261; Ankmy1.
DR eggNOG; ENOG502QQJP; Eukaryota.
DR InParanoid; Q8C0W1; -.
DR OrthoDB; 323321at2759; -.
DR BioGRID-ORCS; 241158; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8C0W1; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8C0W1; protein.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR002893; Znf_MYND.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF02493; MORN; 2.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00698; MORN; 2.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..906
FT /note="Ankyrin repeat and MYND domain-containing protein 1"
FT /id="PRO_0000320065"
FT REPEAT 16..38
FT /note="MORN 1"
FT REPEAT 39..59
FT /note="MORN 2"
FT REPEAT 61..83
FT /note="MORN 3"
FT REPEAT 282..311
FT /note="ANK 1"
FT REPEAT 479..508
FT /note="ANK 2"
FT REPEAT 511..540
FT /note="ANK 3"
FT REPEAT 547..579
FT /note="ANK 4"
FT REPEAT 623..657
FT /note="ANK 5"
FT REPEAT 660..689
FT /note="ANK 6"
FT REPEAT 701..732
FT /note="ANK 7"
FT ZN_FING 845..885
FT /note="MYND-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT REGION 391..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 845
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 848
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 859
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 862
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 868
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 872
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 881
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 885
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT CONFLICT 813
FT /note="Missing (in Ref. 2; AAI20888)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 906 AA; 101999 MW; 436AE985B3E3E5A1 CRC64;
MKLGYGEFSW PTGEAYHGQF YRDHFHGLGT YTWPDGSSFT GTFYLSQREG YGTMHTKTML
FQGLYKEDQR FGPGIETYPD GSQDVGLWFR EYLLKLCTRV PSGFSLVNYP EFLAFLTKSR
RRLDLSDEKV ELGLSEEQDP FFYDYKQYLL NDELKLPPEM HVYSTDNSHL PMTDSLRQEL
DDHIFMNEIP PFIEDEEPWL ITNETPLLVK IQKQTYKFRN KDAHTSWNIP AILEGNRSRF
GPSGPKEQIS KKMIMKAEEG DYNWIFGILR DNLACADVAD SKGYTVLAAA AMHSHLDIVN
LLLDFGADVN KRSDEGITPL SMCFLQYYPC KSFHPNIAER TLLQESPKSL VTPKISFLLA
DANIDYLYDV GMPIAGGDEL KTSSLDDSLA SMQTPESSNM LHKEEVSPVK TVSTDVEKES
EGAAENVDAS TLYSVDTNFE STKCLRNYTI NVSRDIMEKS AQAYSSLPQH PCFPYKGTVR
KMAQSMVERR NRWMTITLLL RRGADPNLCQ VPMQALFLAV KAGDVEGVRL LLMSGAQTDI
QFPPQLQSLT PLHIAVSLPG EEGVKITELL LHVITNVDAK AADEDYVYKG GKADLLPSSL
KLNNEPGPPK SFYSTHTFIP EEGGRTALHV ACEREDNKKC ARDIVRLLLS HRANPNVLWS
GHSPLSLAIA SGNDLVVKEL LSQGADPNLP LTKGLGTALC VVCDLVYEQQ RSVENKIALI
DRLISYGADV LNPVTLVQGD RTAVGTAVDY GYFKFFQDRK IAHCPFHALM PAEREVFMAR
KRLLEYLGLQ LRLAVLSKES RLDTKALYLS KRAELAPCHR LKKKGSSSVR TQSSEKQSIP
FYKFCYQCGR SIGVRLSPCP RCYGILTCSK YCKTKAWIEF HKKDCNDIMA MIPHLEGSAW
RVAESP
