ID   ANO10_DANRE             Reviewed;         646 AA.
AC   Q4V8U5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Anoctamin-10;
DE   AltName: Full=Transmembrane protein 16K;
GN   Name=ano10; Synonyms=tmem16k; ORFNames=zgc:114140;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC)
CC       activity. Can inhibit the activity of ANO1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=Shows predominantly an intracellular
CC       localization with a weak expression in the cell membrane.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: The term 'anoctamin' was coined because these channels
CC       are anion selective and have eight (OCT) transmembrane segments. There
CC       is some dissatisfaction in the field with the Ano nomenclature because
CC       it is not certain that all the members of this family are anion
CC       channels or have the 8-transmembrane topology.
CC   -!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
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DR   EMBL; BC097195; AAH97195.1; -; mRNA.
DR   RefSeq; NP_001025377.1; NM_001030206.1.
DR   AlphaFoldDB; Q4V8U5; -.
DR   SMR; Q4V8U5; -.
DR   STRING; 7955.ENSDARP00000112117; -.
DR   PaxDb; Q4V8U5; -.
DR   GeneID; 566425; -.
DR   KEGG; dre:566425; -.
DR   CTD; 566425; -.
DR   ZFIN; ZDB-GENE-050913-43; ano10a.
DR   eggNOG; KOG2513; Eukaryota.
DR   InParanoid; Q4V8U5; -.
DR   OrthoDB; 1263362at2759; -.
DR   PhylomeDB; Q4V8U5; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q4V8U5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR031291; Anoctamin-10.
DR   PANTHER; PTHR12308; PTHR12308; 1.
DR   PANTHER; PTHR12308:SF40; PTHR12308:SF40; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..646
FT                   /note="Anoctamin-10"
FT                   /id="PRO_0000289959"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        502..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        557..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        592..612
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   646 AA;  74524 MW;  9DB4609FA217FD20 CRC64;
     MQLGLSVSDS DASPFTPLAV LELAHDTKAE AIAWLLNRIR DKQRNGGAEL LVDQLLFPAQ
     DGQKPNPNVF VVGSTLQRLL SGAEDVGLFK EFQDGTMRGF TYANRESFKD FEGDGEGFLG
     DAECQYIVKH ELDTLRAKNE EYIPGYPKYK LYPGKSIVRR LQSKGVLVQY FPLHNKEDLK
     RLSFSWYKKI KLSFQPLDDI RSYFGEGLGL YFGFLEYFTF ALIPMALIGI PYYLFDWEDY
     DKYVLFAVFN LVWSTVFLEV WKRCSATLAY SWGTLGRKKA FEEPRAGFHG PLGLNPVTGR
     EEPIYPSSKR HLRIYLVSVP FVLLCLYLSF YVMMVYFDME FWAISIYHEN PNFATSVLLF
     VPSIIYAVVI EIMNLLYRYA AEFLTDWENH RLESSFQNHL VPKVLVFNFV NCFASLFYIA
     FVMQDMVLLR QSLATLLITS QILNQVMEAF LPYWLQRRRN KRVYKRMRRL MGDKELPLLE
     QIQLETEMNT YLGTFDDYLE QFLLFGYVSL FSCVHPLAAV LVVLNNITEV YSDAFKMCHV
     FKRPFSEPAA NIGVWQLAFE TMSIIAVVTN CALIALSPQV KAYFPESDAQ LILTVVAIEH
     VLLAFKFILA FVIPDVPKHI QVKLSKLDFE SLEALKKRKI LEVAET