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ANO10_MOUSE
ID   ANO10_MOUSE             Reviewed;         659 AA.
AC   Q8BH79; Q4FZD2; Q8BMS8; Q8BV74; Q8BW67; Q8R0U0; Q99LP0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Anoctamin-10;
DE   AltName: Full=Transmembrane protein 16K;
GN   Name=Ano10; Synonyms=Tmem16k;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 193-659 (ISOFORM 4).
RC   STRAIN=C57BL/6J, and Czech II;
RC   TISSUE=Adipose tissue, Corpora quadrigemina, Oviduct, and Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Kidney, Mammary tumor, and Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=18729231; DOI=10.1002/dvdy.21676;
RA   Rock J.R., Harfe B.D.;
RT   "Expression of TMEM16 paralogs during murine embryogenesis.";
RL   Dev. Dyn. 237:2566-2574(2008).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=20056604; DOI=10.1074/jbc.m109.065367;
RA   Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
RA   Martins J.R., Kunzelmann K.;
RT   "Expression and function of epithelial anoctamins.";
RL   J. Biol. Chem. 285:7838-7845(2010).
RN   [6]
RP   REVIEW.
RX   PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
RA   Winpenny J.P., Gray M.A.;
RT   "The anoctamin (TMEM16) gene family: calcium-activated chloride channels
RT   come of age.";
RL   Exp. Physiol. 97:175-176(2012).
CC   -!- FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC)
CC       activity. Can inhibit the activity of ANO1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=Shows predominantly an intracellular
CC       localization with a weak expression in the cell membrane.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8BH79-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BH79-2; Sequence=VSP_026034;
CC       Name=3;
CC         IsoId=Q8BH79-3; Sequence=VSP_026035, VSP_026036;
CC       Name=4;
CC         IsoId=Q8BH79-4; Sequence=VSP_026037;
CC   -!- TISSUE SPECIFICITY: Predominant expression seen in epithelial tissues.
CC       {ECO:0000269|PubMed:20056604}.
CC   -!- DEVELOPMENTAL STAGE: Detected in the mantle layer of the neural tube
CC       and in the dorsal root ganglia at 14.5 dpc.
CC       {ECO:0000269|PubMed:18729231}.
CC   -!- MISCELLANEOUS: The term 'anoctamin' was coined because these channels
CC       are anion selective and have eight (OCT) transmembrane segments. There
CC       is some dissatisfaction in the field with the Ano nomenclature because
CC       it is not certain that all the members of this family are anion
CC       channels or have the 8-transmembrane topology.
CC   -!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH26421.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
CC       Sequence=BAC25927.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC37706.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK028391; BAC25927.1; ALT_SEQ; mRNA.
DR   EMBL; AK046091; BAC32601.1; -; mRNA.
DR   EMBL; AK054163; BAC35676.1; -; mRNA.
DR   EMBL; AK079622; BAC37706.1; ALT_INIT; mRNA.
DR   EMBL; AK080947; BAC38086.1; -; mRNA.
DR   EMBL; BC002294; AAH02294.1; -; mRNA.
DR   EMBL; BC026421; AAH26421.1; ALT_SEQ; mRNA.
DR   EMBL; BC099688; AAH99688.1; -; mRNA.
DR   CCDS; CCDS23645.1; -. [Q8BH79-1]
DR   CCDS; CCDS90687.1; -. [Q8BH79-2]
DR   RefSeq; NP_001258802.1; NM_001271873.1. [Q8BH79-2]
DR   RefSeq; NP_598740.1; NM_133979.3. [Q8BH79-1]
DR   RefSeq; XP_011241230.1; XM_011242928.2. [Q8BH79-4]
DR   AlphaFoldDB; Q8BH79; -.
DR   SMR; Q8BH79; -.
DR   IntAct; Q8BH79; 1.
DR   STRING; 10090.ENSMUSP00000045214; -.
DR   PhosphoSitePlus; Q8BH79; -.
DR   EPD; Q8BH79; -.
DR   MaxQB; Q8BH79; -.
DR   PaxDb; Q8BH79; -.
DR   PeptideAtlas; Q8BH79; -.
DR   PRIDE; Q8BH79; -.
DR   ProteomicsDB; 296305; -. [Q8BH79-1]
DR   ProteomicsDB; 296306; -. [Q8BH79-2]
DR   ProteomicsDB; 296307; -. [Q8BH79-3]
DR   ProteomicsDB; 296308; -. [Q8BH79-4]
DR   Antibodypedia; 29353; 75 antibodies from 25 providers.
DR   DNASU; 102566; -.
DR   Ensembl; ENSMUST00000042546; ENSMUSP00000045214; ENSMUSG00000037949. [Q8BH79-1]
DR   Ensembl; ENSMUST00000214409; ENSMUSP00000151189; ENSMUSG00000037949. [Q8BH79-2]
DR   Ensembl; ENSMUST00000216670; ENSMUSP00000150161; ENSMUSG00000037949. [Q8BH79-3]
DR   GeneID; 102566; -.
DR   KEGG; mmu:102566; -.
DR   UCSC; uc009ser.2; mouse. [Q8BH79-1]
DR   UCSC; uc009ses.2; mouse. [Q8BH79-2]
DR   UCSC; uc009seu.1; mouse. [Q8BH79-4]
DR   CTD; 55129; -.
DR   MGI; MGI:2143103; Ano10.
DR   VEuPathDB; HostDB:ENSMUSG00000037949; -.
DR   eggNOG; KOG2513; Eukaryota.
DR   GeneTree; ENSGT00940000157537; -.
DR   HOGENOM; CLU_006685_2_3_1; -.
DR   InParanoid; Q8BH79; -.
DR   OMA; NLGVDWV; -.
DR   OrthoDB; 1263362at2759; -.
DR   PhylomeDB; Q8BH79; -.
DR   TreeFam; TF314265; -.
DR   Reactome; R-MMU-2672351; Stimuli-sensing channels.
DR   BioGRID-ORCS; 102566; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Ano10; mouse.
DR   PRO; PR:Q8BH79; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BH79; protein.
DR   Bgee; ENSMUSG00000037949; Expressed in interventricular septum and 213 other tissues.
DR   ExpressionAtlas; Q8BH79; baseline and differential.
DR   Genevisible; Q8BH79; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0005227; F:calcium activated cation channel activity; ISO:MGI.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR   GO; GO:0006812; P:cation transport; ISO:MGI.
DR   GO; GO:0006821; P:chloride transport; ISO:MGI.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR031291; Anoctamin-10.
DR   PANTHER; PTHR12308; PTHR12308; 1.
DR   PANTHER; PTHR12308:SF40; PTHR12308:SF40; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..659
FT                   /note="Anoctamin-10"
FT                   /id="PRO_0000289958"
FT   TOPO_DOM        1..207
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..240
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338..352
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        374..400
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        422..500
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        501..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        522..553
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        575..590
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        612..659
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         198..255
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_026034"
FT   VAR_SEQ         600..612
FT                   /note="HALLALKFILAFA -> VLGLQASFTIGFY (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026035"
FT   VAR_SEQ         613..659
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026036"
FT   VAR_SEQ         639..659
FT                   /note="QMKLVAENLKEEYQEDGKEAT -> VRAVCLETLLDYIPLAQAPSHCVSFSM
FT                   DLSVK (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026037"
SQ   SEQUENCE   659 AA;  76188 MW;  435D9A08D48F93FC CRC64;
     MRVTLSTLDT CESSFTPLVV IELAQDVKDE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE
     KETLENQNLY LVGASNVRLL LGAEAVGLVK ECTDAAMRAF TYGTRHNFKG FHDNNNDFLT
     MAECQFIIKH ELENLRARDE KMIPGYPQAK LYPGKSLMRR LLTSGIVTQV FPLHDTEALK
     KLEDTWYTRF ALKYQPIDSI RSYFGETIAL YFGFLEYFTF ALIPMAIIGL PYYLFVWEDY
     DKYVIFASFN LIWSTVILEV WKRGCANMTY RWGTLVMKRQ FEEPRPGFHG VLGINSVTGR
     EEPLYSSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME DWALSLHEDS GSEWTSLLLY
     VPSIVYAVVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL VLKVLVFNFL NCFASLFYIA
     FVLKDMKLLR QSLATLLITS QILNQVVESL LPYWLQRKYC ARVKRKVQAL KSEVDTTLYE
     QVLLEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV
     FKRPFAEPSA SIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKTD LVLIVVAVEH
     ALLALKFILA FAIPDKPRHI QQKLARLEFE SLEALKQQQM KLVAENLKEE YQEDGKEAT
 
 
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