HIS4_RHOCB
ID HIS4_RHOCB Reviewed; 239 AA.
AC O30725; D5ARP1;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE EC=5.3.1.16;
DE AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN Name=hisA; OrderedLocusNames=RCAP_rcc01154;
OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=272942;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MT1131;
RX PubMed=9473054; DOI=10.1128/jb.180.4.969-978.1998;
RA Koch H.G., Hwang O., Daldal F.;
RT "Isolation and characterization of Rhodobacter capsulatus mutants affected
RT in cytochrome cbb3 oxidase activity.";
RL J. Bacteriol. 180:969-978(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX PubMed=20418398; DOI=10.1128/jb.00366-10;
RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V.,
RA Haselkorn R.;
RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium
RT Rhodobacter capsulatus SB 1003.";
RL J. Bacteriol. 192:3545-3546(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-
CC ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-
CC phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-
CC ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469,
CC ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000305}.
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DR EMBL; AF016223; AAC46106.1; -; Genomic_DNA.
DR EMBL; CP001312; ADE84912.1; -; Genomic_DNA.
DR RefSeq; WP_013066891.1; NC_014034.1.
DR AlphaFoldDB; O30725; -.
DR SMR; O30725; -.
DR STRING; 272942.RCAP_rcc01154; -.
DR EnsemblBacteria; ADE84912; ADE84912; RCAP_rcc01154.
DR GeneID; 31490067; -.
DR KEGG; rcp:RCAP_rcc01154; -.
DR eggNOG; COG0106; Bacteria.
DR HOGENOM; CLU_048577_1_1_5; -.
DR OMA; EWLHLVD; -.
DR OrthoDB; 794219at2; -.
DR UniPathway; UPA00031; UER00009.
DR Proteomes; UP000002361; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04732; HisA; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01014; HisA; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR006063; HisA_bact_arch.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR023016; Isoase_HisA-like_bact.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR43090; PTHR43090; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR TIGRFAMs; TIGR00007; TIGR00007; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Isomerase;
KW Reference proteome.
FT CHAIN 1..239
FT /note="1-(5-phosphoribosyl)-5-[(5-
FT phosphoribosylamino)methylideneamino] imidazole-4-
FT carboxamide isomerase"
FT /id="PRO_0000142044"
FT ACT_SITE 8
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 129
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT CONFLICT 210
FT /note="D -> N (in Ref. 1; AAC46106)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="I -> F (in Ref. 1; AAC46106)"
FT /evidence="ECO:0000305"
FT CONFLICT 223..225
FT /note="IYD -> LYN (in Ref. 1; AAC46106)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="D -> N (in Ref. 1; AAC46106)"
FT /evidence="ECO:0000305"
FT CONFLICT 235..239
FT /note="AALKA -> RP (in Ref. 1; AAC46106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 24468 MW; E5ACBE5A88A1ABCC CRC64;
MILYPAIDLK DGNCVRLLHG EMDKATVFGT DPAAQAAKFE AAGCAWVHLV DLNGAFAGEP
VNGAAVEAIL ARITVPAQLG GGIRDMATIE RWLSKGLARV ILGTVAVENP DLVREAAKAF
PGQVAVGIDA RNGKVATKGW ATETDVLVTD LAQSFEDAGV AAIIYTDILR DGAMTGPNIE
ATEALGRAVT IPVIASGGVS SLPDLIALRD TGVIAGAISG RAIYDGALDL QAALAALKA