ID   3SO8_BUNMU              Reviewed;          86 AA.
AC   Q9W727;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Muscarinic toxin-like protein;
DE   Flags: Precursor;
OS   Bungarus multicinctus (Many-banded krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Qian Y.C., Fang C.Y., Gong Y., Yang S.-L.;
RT   "Molecular cloning of neurotoxin-like proteins from Bungarus multicinctus
RT   multicinctus.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antagonist of muscle and neuronal nicotinic acetylcholine
CC       receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7
CC       nAChRs. {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBUNIT: Homodimer; non-covalently linked.
CC       {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A8N286}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group VIII (haditoxin) sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ007764; CAB50691.1; -; mRNA.
DR   AlphaFoldDB; Q9W727; -.
DR   SMR; Q9W727; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..86
FT                   /note="Muscarinic toxin-like protein"
FT                   /id="PRO_0000035482"
FT   DISULFID        24..45
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        38..62
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        66..78
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        79..84
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   86 AA;  9934 MW;  1FB62E46006A3F15 CRC64;
     MKTLLLTLAV VTMVCMDLGY TTICYNHLSR TPETTEICPD SWYFCYKISL ADGNDVRIKR
     GCTFTCPELR PTGKYVYCCR RDKCNQ