位置:首页 > 蛋白库 > ANO5_MOUSE
ANO5_MOUSE
ID   ANO5_MOUSE              Reviewed;         904 AA.
AC   Q75UR0; Q2VPA8; Q3V657; Q8CC04;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Anoctamin-5;
DE   AltName: Full=Gnathodiaphyseal dysplasia 1 protein homolog;
DE   AltName: Full=Transmembrane protein 16E;
GN   Name=Ano5; Synonyms=Gdd1, Tmem16e;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RC   STRAIN=BALB/cJ; TISSUE=Skeletal muscle;
RX   PubMed=15124103; DOI=10.1086/421527;
RA   Tsutsumi S., Kamata N., Vokes T.J., Maruoka Y., Nakakuki K., Enomoto S.,
RA   Omura K., Amagasa T., Nagayama M., Saito-Ohara F., Inazawa J., Moritani M.,
RA   Yamaoka T., Inoue H., Itakura M.;
RT   "The novel gene encoding a putative transmembrane protein is mutated in
RT   gnathodiaphyseal dysplasia (GDD).";
RL   Am. J. Hum. Genet. 74:1255-1261(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RC   STRAIN=BDF1; TISSUE=Skeletal muscle;
RX   PubMed=15882990; DOI=10.1016/j.bbrc.2005.03.226;
RA   Tsutsumi S., Inoue H., Sakamoto Y., Mizuta K., Kamata N., Itakura M.;
RT   "Molecular cloning and characterization of the murine gnathodiaphyseal
RT   dysplasia gene GDD1.";
RL   Biochem. Biophys. Res. Commun. 331:1099-1106(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=17418107; DOI=10.1016/j.bbrc.2007.03.108;
RA   Mizuta K., Tsutsumi S., Inoue H., Sakamoto Y., Miyatake K., Miyawaki K.,
RA   Noji S., Kamata N., Itakura M.;
RT   "Molecular characterization of GDD1/TMEM16E, the gene product responsible
RT   for autosomal dominant gnathodiaphyseal dysplasia.";
RL   Biochem. Biophys. Res. Commun. 357:126-132(2007).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=20056604; DOI=10.1074/jbc.m109.065367;
RA   Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
RA   Martins J.R., Kunzelmann K.;
RT   "Expression and function of epithelial anoctamins.";
RL   J. Biol. Chem. 285:7838-7845(2010).
RN   [7]
RP   REVIEW.
RX   PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
RA   Winpenny J.P., Gray M.A.;
RT   "The anoctamin (TMEM16) gene family: calcium-activated chloride channels
RT   come of age.";
RL   Exp. Physiol. 97:175-176(2012).
CC   -!- FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC)
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:17418107}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:17418107}. Cell membrane
CC       {ECO:0000269|PubMed:17418107}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Colocalized with CALR/calreticulin. Shows an
CC       intracellular localization. {ECO:0000250|UniProtKB:Q75V66}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=At least 14 isoforms are produced using different
CC         combinations of exons 4, 6, 16, 20 and 21.;
CC       Name=1;
CC         IsoId=Q75UR0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q75UR0-2; Sequence=VSP_015628, VSP_015629, VSP_015630,
CC                                  VSP_015631;
CC       Name=3;
CC         IsoId=Q75UR0-3; Sequence=VSP_035571, VSP_035572;
CC   -!- TISSUE SPECIFICITY: Highly expressed in skeletal muscle, bone tissues
CC       and thyroid gland. {ECO:0000269|PubMed:15124103,
CC       ECO:0000269|PubMed:15882990, ECO:0000269|PubMed:17418107,
CC       ECO:0000269|PubMed:20056604}.
CC   -!- DEVELOPMENTAL STAGE: In the developing embryo, expressed mainly in
CC       differentiating and developing somites and is associated with myotomal
CC       somite lineages. {ECO:0000269|PubMed:17418107}.
CC   -!- INDUCTION: Up-regulated during the course of myogenic differentiation.
CC       Down-regulated during osteoblastic differentiation.
CC       {ECO:0000269|PubMed:15124103, ECO:0000269|PubMed:15882990}.
CC   -!- MISCELLANEOUS: The term 'anoctamin' was coined because these channels
CC       are anion selective and have eight (OCT) transmembrane segments. There
CC       is some dissatisfaction in the field with the Ano nomenclature because
CC       it is not certain that all the members of this family are anion
CC       channels or have the 8-transmembrane topology.
CC   -!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB125740; BAD17873.1; -; mRNA.
DR   EMBL; AB206762; BAE44438.1; -; mRNA.
DR   EMBL; AK034197; BAC28628.1; -; mRNA.
DR   EMBL; BC109163; AAI09164.2; -; mRNA.
DR   CCDS; CCDS39968.1; -. [Q75UR0-1]
DR   CCDS; CCDS85311.1; -. [Q75UR0-3]
DR   RefSeq; NP_001258808.1; NM_001271879.1. [Q75UR0-3]
DR   RefSeq; NP_808362.2; NM_177694.6. [Q75UR0-1]
DR   AlphaFoldDB; Q75UR0; -.
DR   SMR; Q75UR0; -.
DR   STRING; 10090.ENSMUSP00000046884; -.
DR   TCDB; 1.A.17.1.2; the calcium-dependent chloride channel (ca-clc) family.
DR   GlyGen; Q75UR0; 6 sites.
DR   iPTMnet; Q75UR0; -.
DR   PhosphoSitePlus; Q75UR0; -.
DR   PaxDb; Q75UR0; -.
DR   PRIDE; Q75UR0; -.
DR   Antibodypedia; 53749; 79 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000043944; ENSMUSP00000046884; ENSMUSG00000055489. [Q75UR0-1]
DR   Ensembl; ENSMUST00000207044; ENSMUSP00000147243; ENSMUSG00000055489. [Q75UR0-2]
DR   Ensembl; ENSMUST00000207717; ENSMUSP00000146783; ENSMUSG00000055489. [Q75UR0-3]
DR   GeneID; 233246; -.
DR   KEGG; mmu:233246; -.
DR   UCSC; uc009hcc.2; mouse. [Q75UR0-1]
DR   UCSC; uc009hce.2; mouse. [Q75UR0-2]
DR   UCSC; uc033izs.1; mouse. [Q75UR0-3]
DR   CTD; 203859; -.
DR   MGI; MGI:3576659; Ano5.
DR   VEuPathDB; HostDB:ENSMUSG00000055489; -.
DR   eggNOG; KOG2514; Eukaryota.
DR   GeneTree; ENSGT00940000155692; -.
DR   HOGENOM; CLU_006685_1_4_1; -.
DR   InParanoid; Q75UR0; -.
DR   OMA; LRNVQYW; -.
DR   OrthoDB; 1263362at2759; -.
DR   PhylomeDB; Q75UR0; -.
DR   TreeFam; TF314265; -.
DR   Reactome; R-MMU-2672351; Stimuli-sensing channels.
DR   BioGRID-ORCS; 233246; 2 hits in 73 CRISPR screens.
DR   PRO; PR:Q75UR0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q75UR0; protein.
DR   Bgee; ENSMUSG00000055489; Expressed in quadriceps femoris and 48 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0031982; C:vesicle; IDA:MGI.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006821; P:chloride transport; ISO:MGI.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR031294; Anoctamin-5.
DR   PANTHER; PTHR12308; PTHR12308; 1.
DR   PANTHER; PTHR12308:SF23; PTHR12308:SF23; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Endoplasmic reticulum; Glycoprotein;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..904
FT                   /note="Anoctamin-5"
FT                   /id="PRO_0000191756"
FT   TOPO_DOM        1..290
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..371
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        393..453
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        475..502
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        524..548
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        549..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        570..667
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        668..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        689..723
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        724..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        745..825
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        826..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        847..904
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        326
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        357
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        371
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        759
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        769
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        782
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..33
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_015628"
FT   VAR_SEQ         34..52
FT                   /note="DLQSPPEKRFNLFLRRRLM -> MNLGSKETSFLIPEDLQSP (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_015629"
FT   VAR_SEQ         39..52
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035571"
FT   VAR_SEQ         535..570
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035572"
FT   VAR_SEQ         796..805
FT                   /note="RYRDYRYPPD -> STSCFCLNFY (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_015630"
FT   VAR_SEQ         806..904
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_015631"
SQ   SEQUENCE   904 AA;  106214 MW;  347FA6BC33FA0042 CRC64;
     MVEQEGLTAK EIDYAFQQNE NLGSKETSFL IPEDLQSPPE KRFNLFLRRR LMFQRSEHSK
     DSVFFRDGIR QIDFVLSYVE DLKKDGELKA ERRREFEQNL RKTGLDLETE DKLNSEDGKT
     YFVKIHAPWE VLVTYAEVLG IKMPIKLSDI PRPKYPPLSY MLGAVKLPSS VKYPTPEYFT
     AQFSRHRQEL FLIEDEATFF PSSTRNRIVY YILSRCPFGV EEGKKKIGIE RLLNSNTYLS
     AYPLHDGQYW KPSKTTRPNE RYNLCKNWAR FSYFYKEQPF HLIRNYFGEK IGIYFVFLGY
     YTEMLLFAAL VGLACFIYGL LSMENNRTST EICDPDIGGQ MIMCPLCDEV CDYWRLNTTC
     LHSKFSHLFD NESTVFFALF MGIWVTLFLE FWKQRQARLE YEWDLVDFEE EQQQLQLRPE
     FEAMCKHKKM NPVTKEMEPH MPLCHRIPWY FVSGTTVTFG MALLLSSMVS ILIYRLSVFA
     TFASFMESEA TLQSVKSFFT PQLATALSGS CLNCIVILIL NFFYEKISAW ITKMEIPRTH
     QEYESSLTLK MFLFQFVNYY SSCFYVAFFK GKFVGYPGSY TYMFNIWRSE ECGPAGCLIE
     LTTQLTIIMI GKQIFGNIHE AFQPLIFNWW RRRRARTHSE KLYSRWEQDH DLQVYGHRGL
     FYEYLETVIQ FGFATLFVAS FPLAPLFALM NNIMGIRVDA WKLTTQYRRP VAAKAHSIGV
     WQDILFGMAI VSVATNAFIV SFTSDIIPRL VYFYAYSTNS TEPLSGYVNN SLSVFLIADF
     PNHTVPMEKK DFVTCRYRDY RYPPDHEDKY SHNMQFWHVL AAKMTFIIVM EHVVFLFKFL
     LAWLIPDVPK DVVEKIKREK LMTIKIIHDF ELNKLKENLD VEYGNIMKNV LVDEDNSLKA
     KTTV
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024