ID   3SO8_NAJAT              Reviewed;          86 AA.
AC   Q9DEQ3;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Neurotoxin homolog NL1;
DE   Flags: Precursor;
OS   Naja atra (Chinese cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Qian Y.-C., Fang C.-Y., Gong Y., Yang S.-L.;
RT   "cDNA cloning of neurotoxin homologue from naja naja atra.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antagonist of muscle and neuronal nicotinic acetylcholine
CC       receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7
CC       nAChRs. {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBUNIT: Homodimer; non-covalently linked.
CC       {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A8N286}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group VIII (haditoxin) sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ001186; CAC08183.1; -; mRNA.
DR   AlphaFoldDB; Q9DEQ3; -.
DR   SMR; Q9DEQ3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..86
FT                   /note="Neurotoxin homolog NL1"
FT                   /id="PRO_0000035472"
FT   DISULFID        24..45
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        38..62
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        66..78
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        79..84
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   86 AA;  9962 MW;  0719C9160078A69E CRC64;
     MKTLLLTLVV VTMVCMDLGY TTICYNHLSR TPETTEICPD SWYFCYKISL ADGNDVRIKR
     GCTFTCPELR PTGKYVYCCR RDKCNQ