ID   3SO8_NAJNA              Reviewed;          26 AA.
AC   P86544;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Muscarinic toxin-like protein 1 {ECO:0000303|PubMed:20203422};
DE            Short=MTLP-1 {ECO:0000303|PubMed:20203422};
DE   AltName: Full=Muscarinic toxin-like protein 2 {ECO:0000303|PubMed:20203422};
DE            Short=MTLP-2 {ECO:0000303|PubMed:20203422};
DE   Flags: Fragment;
OS   Naja naja (Indian cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=35670;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20203422; DOI=10.2220/biomedres.31.71;
RA   Suzuki M., Itoh T., Bandaranayake B.M.A.I.K., Ranasinghe J.G.,
RA   Athauda S.B., Moriyama A.;
RT   "Molecular diversity in venom proteins of the Russell's viper (Daboia
RT   russellii russellii) and the Indian cobra (Naja naja) in Sri Lanka.";
RL   Biomed. Res. 31:71-81(2010).
CC   -!- FUNCTION: Antagonist of muscle and neuronal nicotinic acetylcholine
CC       receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7
CC       nAChRs. {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBUNIT: Homodimer; non-covalently linked.
CC       {ECO:0000250|UniProtKB:A8N286}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20203422}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group VIII (haditoxin) sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P86544; -.
DR   Proteomes; UP000694559; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond;
KW   G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Reference proteome; Secreted; Toxin.
FT   CHAIN           1..>26
FT                   /note="Muscarinic toxin-like protein 1"
FT                   /evidence="ECO:0000269|PubMed:20203422"
FT                   /id="PRO_0000394693"
FT   DISULFID        3..?
FT                   /evidence="ECO:0000250|UniProtKB:P82464"
FT   DISULFID        17..?
FT                   /evidence="ECO:0000250|UniProtKB:P82464"
FT   NON_TER         26
FT                   /evidence="ECO:0000303|PubMed:20203422"
SQ   SEQUENCE   26 AA;  3144 MW;  F02652BF29D74D58 CRC64;
     TICYNHLTIR SEVTEICIIC DDDYYF